Effects of verapamil on the release of different neurotransmitters

Sitges, Marı́a; Reyes, Ariel J.

doi:10.1002/jnr.490400506

Cited by 16 publications

(6 citation statements)

References 34 publications

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“…The release is dose dependent and mediated by presynaptic receptors. This increase in endogenous 5-HT is independent of the presence of external calcium [60]. Serotonin activates 5-HT 1A receptors to produce an antidepressant effect [61].…”

Section: Discussionmentioning

confidence: 99%

Effects of Calcium Channel Blockers on Antidepressant Action of Alprazolam and Imipramine

Sm¹,

Ra²,

Alghzewi³

et al. 2007

Libyan J Med

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Alprazolam is effective as an anxiolytic and in the adjunct treatment of depression. In this study, the effects of calcium channel antagonists on the antidepressant action of alprazolam and imipramine were investigated. A forced swimming maze was used to study behavioral despair in albino mice. Mice were divided into nine groups (n = 7 per group). One group received a single dose of 1% Tween 80; two groups each received a single dose of the antidepressant alone (alprazolam or imipramine); two groups each received a single dose of the calcium channel blocker (nifedipine or verapamil); four groups each received a single dose of the calcium channel blocker followed by a single dose of the antidepressant (with same doses used for either in the previous four groups). Drug administration was performed concurrently on the nine groups. Our data confirmed the antidepressant action of alprazolam and imipramine. Both nifedipine and verapamil produced a significant antidepressant effect (delay the onset of immobility) when administered separately. Verapamil augmented the antidepressant effects of alprazolam and imipramine (additive antidepressant effect). This may be due to the possibility that verapamil might have antidepressant-like effect through different mechanism. Nifedipine and imipramine combined led to a delay in the onset of immobility greater than their single use but less than the sum of their independent administration. This may be due to the fact that nifedipine on its own might act as an antidepressant but blocks one imipramine mechanism that depends on L-type calcium channel activation. Combining nifedipine with alprazolam produced additional antidepressant effects, which indicates that they exert antidepressant effects through different mechanisms.

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Section: Discussionmentioning

confidence: 99%

Effects of Calcium Channel Blockers on Antidepressant Action of Alprazolam and Imipramine

Sm¹,

Ra²,

Alghzewi³

et al. 2007

Libyan J Med

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show abstract

“…At 10 μM verapamil (for 5 min) increases endogenous dopamine release by 70% independently on the presence of external Ca 2+ . [341] According DrugMatrix in vitro pharmacology data [325] verapamil inhibits dopamine D 3 receptor in radioligand binding assay with [ 3 H]spiperone as radioligand with K i of 63 nM; human B max due to the verapamil, with the decrease being notably more extreme in the hippocampus. However, there was no evidence from in vitro experiments that verapamil had a direct effect on the brain benzodiazepine receptors.…”

Section: Verapamil Potassium Channels Blockingmentioning

confidence: 99%

“…At 10 μM verapamil (for 5 min) increases endogenous dopamine release by 70% independently on the presence of external Ca 2+ . [ 341 ] According DrugMatrix in vitro pharmacology data [ 325 ] verapamil inhibits dopamine D 3 receptor in radioligand binding assay with [ 3 H]spiperone as radioligand with K i of 63 nM; human H 2 ‐receptor in [ 125 I]aminopotentidine radioligand binding assay with K i of 2547 nM.…”

Section: The Most Well‐studied Multitarget Drugs With Linked Biaromat...mentioning

confidence: 99%

Multitargeting in cardioprotection: An example of biaromatic compounds

Mokrov

2023

Archiv der Pharmazie

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A multitarget drug design approach is actively developing in modern medicinal chemistry and pharmacology, especially with regard to multifactorial diseases such as cardiovascular diseases, cancer, and neurodegenerative diseases. A detailed study of many well‐known drugs developed within the single‐target approach also often reveals additional mechanisms of their real pharmacological action. One of the multitarget drug design approaches can be the identification of the basic pharmacophore models corresponding to a wide range of the required target ligands. Among such models in the group of cardioprotectors is the linked biaromatic system. This review develops the concept of a “basic pharmacophore” using the biaromatic pharmacophore of cardioprotectors as an example. It presents an analysis of possible biological targets for compounds corresponding to the biaromatic pharmacophore and an analysis of the spectrum of biological targets for the five most known and most studied cardioprotective drugs corresponding to this model, and their involvement in the biological effects of these drugs.

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“…It has a similar final effect as β blockers, and shares this effect with antidepressant drugs. Working on different types of calcium entry, verapamil blocks the prejunctional α 2 receptors, which leads to an increase in NA release 18 . Verapamil may have direct catecholamine releasing effects, as it interacts with catecholamine storage vesicles in a way that reduces their ability to take up and store catecholamine, and thereby increasing NA release from sympathetic nerves 17 .…”

Section: Table 1: Effects Ofmentioning

confidence: 99%

Study on Exploration of Effect of Voltage Gated Calcium Channel Blockers on the Anti Depressant Action of Imipramine and Alprazolam

Bandyopadhyay

2013

J. Drug Delivery Ther.

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Background: Imipramine is a tricyclic anti depressant drug. Alprazolam is a benzodiazepine sedative drug, but it has also antidepressive action. Voltage gated calcium channel blockers are well known antihypertensive, anti anginal, anti arrhythmic drugs. Objective: In this study I explored the effects of calcium channel antagonists on the antidepressant action of alprazolam and imipramine. Materials And Methods: Despair swim test model was used to study the anti depressive effect on the Male Sprague-Dawley rats. Rats were divided into nine groups (n = 6 per group). One group received a single dose of Tween 80 solution, as because it was used as vehicle for all the drugs; two groups each received a single dose of the antidepressant alone (alprazolam or imipramine); two groups each received a single dose of the calcium channel blocker (nifedipine or verapamil); four groups each received a single dose of the calcium channel blocker followed by a single dose of the antidepressant (with same doses used for either in the previous four groups). Drug administration was performed concurrently on the nine groups. Results: The anti depressant action of both imipramine and alprazolam was confirmed by this study. . Both verapamil & nifedipine delays the onset of immobility, when administered separately. Verapamil potentiate the antidepressive effect of both imipramine & alprazolam. When nifedipine was combined with imipramine , there was delay in the onset of immobility and was greater than their single use. . Either imipramine or nifedipine produced a delay in the onset of immobility of 75% and 81%, respectively, compared to the control( p< 0.05) and combining nifedipine with imipramine led to a delay of 73% in the onset of immobility compared to the control ( p< 0.05). Conclusion: Combination of voltage gated calcium channel blocker with imipramine and alprazolam was some positive effect on the antidepressant action.

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Effects of verapamil on the release of different neurotransmitters

Cited by 16 publications

References 34 publications

Effects of Calcium Channel Blockers on Antidepressant Action of Alprazolam and Imipramine

Effects of Calcium Channel Blockers on Antidepressant Action of Alprazolam and Imipramine

Multitargeting in cardioprotection: An example of biaromatic compounds

Study on Exploration of Effect of Voltage Gated Calcium Channel Blockers on the Anti Depressant Action of Imipramine and Alprazolam

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