Neurocognitive similarities between severe chronic schizophrenia and behavioural variant frontotemporal dementia

Chan, Howard; Stolwyk, Renerus-John; Neath, Joanna; Kelso, Wendy; Walterfang, Mark; Mocellin, Ramon; Pantelis, Christos; Velakoulis, Dennis

doi:10.1016/j.psychres.2014.11.029

Cited by 12 publications

(11 citation statements)

References 54 publications

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“…Research has shown significant crossover in symptoms and presentation between patients with primary psychiatric disorders and neurodegenerative disease, so caution must be exercised in diagnosis in these patients. 28–30 Although inclusion of these cases with behavioral or mood symptoms in the research design makes sense, specificity of diagnosis should be favored in the clinical setting.…”

Section: Existing Clinical Criteria For Tesmentioning

confidence: 99%

A Clinical Approach to the Diagnosis of Traumatic Encephalopathy Syndrome

et al. 2016

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Section: Existing Clinical Criteria For Tesmentioning

confidence: 99%

A Clinical Approach to the Diagnosis of Traumatic Encephalopathy Syndrome

et al. 2016

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“…On LILACS, none of the nine retrieved met the requirements. Therefore, 42 articles were selected, of which 10 were cohort studies 15,16,17,18,19,20,21,22,23,24 , three were case-control studies 25,26,27 , 12 were case repo rts 28,29,30,31,32,33,34,35,36,37,38,39 and 17 other studies were cross-sectional surveys 6,7,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54 .…”

Section: Resultsmentioning

confidence: 99%

“…However, this expansion was not found in four other cohorts of BD (n = 206), SCZ (n = 192, n = 466) and in treatment-resistant SCZ (n = 386) 16,18,19,22 . Cross-sectional studies comparing the neurocognitive profile between bvFTD and psychiatric disorders mostly found no remarkable differences 44,45,47,53 , or pointed to less severe deficits in bvFTD 49,55 . Lastly, there were several case reports that established a definite FTLD diagnosis, through genetic or histopathological examination, in patients with previous diagnoses or clinical histories compatible with BD/SCZ/SZA or atypical psychiatric symptoms 28,29,30,31,32,33,34,35,36,37,38,39 .…”

Section: Resultsmentioning

confidence: 99%

Behavioral variant frontotemporal dementia in patients with previous severe mental illness: a systematic and critical review

Gambogi

Guimarães

Souza

et al. 2019

Arq. Neuro-Psiquiatr.

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Objectives: To explore the relationship between severe/serious mental illness (SMI) and the behavioral variant of frontotemporal dementia (bvFTD), as the patterns of symptoms and cognitive performance that characterize both disorders share similarities. Methods: We performed a systematic review investigating what has already been published regarding the relationship between bvFTD and SMI. Studies were selected from PubMed and LILACS databases, including those published up to February 12, 2018. The search strategy included the following terms: “frontotemporal dementia” plus “bipolar”, OR “frontotemporal dementia” plus “schizophrenia”, OR “frontotemporal dementia” plus “schizoaffective”. Publications without abstracts, case reports with absent genetic or histopathological confirmation, reviews and non-English language papers were excluded across the search process. Results: The search on PubMed retrieved 186 articles, of which 42 met eligibility criteria. On the LILACS database, none met the requirements. Generally, three major research aims were identified: 1) to look for frontotemporal lobar degeneration-associated genetic abnormalities in patients with prior SMI; 2) to compare the cognitive profile between patients affected by neurodegenerative disorders and schizophrenic patients; 3) to highlight the association between bvFTD and preceding psychiatric conditions and/or distinguish them both. The investigated mutations were found infrequently in the studied SMI samples. Cross-sectional studies comparing cognitive performance between bvFTD and psychiatric disorders mostly found no remarkable differences. There were only a few case reports identifying definite frontotemporal lobar degeneration in patients with previous psychiatric diagnoses. Conclusions: The available evidence demonstrates how fragile the current understanding is regarding the association between bvFTD and prior SMI.

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“…Entretanto, ambas apresentam aspectos que interferem na capacidade funcional desses pacientes: déficits nas funções sociais e emocionais e no processamento da informação (Eack et al, 2013;Lugnegard, Unenge Hallerback, Hjarthag, & Gillberg, 2013). A esquizofrenia também compartilha algumas características com quadros de demência (Chan et al, 2015), que também impactam no funcionamento dos pacientes na vida cotidiana. Uma vez que a funcionalidade é estudada em quadros como autismo e demência, fez-se necessária a seleção de estudos que abordassem o tema apenas no contexto do paciente com esquizofrenia.…”

Section: Métodounclassified

Perspectivas conceituais e instrumentos para avaliação de funcionalidade em pacientes com esquizofrenia

Amorim¹,

Neto²,

Archer³

et al. 2017

Aval. Psicol.

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Pacientes diagnosticados com esquizofrenia apresentam déficits variados e podem necessitar de cuidados e acompanhamento constantes. Entender os aspectos da funcionalidade desses pacientes torna-se essencial para compreender o transtorno de forma mais completa. Para isso, é necessário identificar as perspectivas conceituais de funcionalidade e verificar os instrumentos disponíveis para avaliar esse fenômeno. Foi realizada uma revisão integrativa em artigos científicos nas línguas portuguesa e inglesa. Em relação às perspectivas conceituais, os resultados apontaram aspectos cognitivos e sintomas negativos enquanto variáveis preditoras da funcionalidade, e os aspectos constituintes do construto funcionalidade foram sintetizados em um modelo composto por dois domínios: objetivo e subjetivo. Foram encontrados 43 instrumentos utilizados para avaliar a funcionalidade em pacientes com esquizofrenia. Desses, 36 instrumentos, apesar de terem sido utilizados em pacientes com esquizofrenia, não eram específicos para esse contexto. Sugere-se que instrumentos sejam desenvolvidos e adaptados para o contexto dos pacientes com esquizofrenia levando em consideração o conhecimento e perspectivas conceituais já existentes na área. Palavras-chave: avaliação psicológica; esquizofrenia; funcionalidade; instrumentos de medida. ABSTRACT-Conceptual Perspectives and Instruments for Functional Evaluation in Patients with Schizophrenia Patients diagnosed with schizophrenia present varied deficits and may require constant care and company. Understanding the functional aspects of these patients becomes essential to understanding the disorder more fully. For this, the conceptual perspectives of functionality must be identified, and the instruments available to evaluate this phenomenon must be verified. An integrative review was conducted on scientific articles in Portuguese and English. Regarding the conceptual perspectives, the results pointed out cognitive aspects and negative symptoms as variables predicting functionality, and the constituent aspects of the construct functionality were synthesized in a model composed of two domains: objective and subjective. We found 43 instruments used to evaluate functionality in patients with schizophrenia. Of these, 36 instruments, although they were used in patients with schizophrenia, were not specific to this context. It is suggested that instruments be developed and adapted to the context of patients with schizophrenia taking into account the knowledge and conceptual perspectives already existing in the area.

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Neurocognitive similarities between severe chronic schizophrenia and behavioural variant frontotemporal dementia

Cited by 12 publications

References 54 publications

A Clinical Approach to the Diagnosis of Traumatic Encephalopathy Syndrome

A Clinical Approach to the Diagnosis of Traumatic Encephalopathy Syndrome

Behavioral variant frontotemporal dementia in patients with previous severe mental illness: a systematic and critical review

Perspectivas conceituais e instrumentos para avaliação de funcionalidade em pacientes com esquizofrenia

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