Neurodevelopment in Early Childhood Affected by Prenatal Lead Exposure and Iron Intake

Shah-Kulkarni, Surabhi; Ha, Mina; Kim, Byungmi; Kim, Eun-Jeong; Hong, Yun–Chul; Park, Hyesook; Kim, Yangho; Kim, Bung-Nyun; Chang, Namsoo; Oh, Se‐Young; Kim, Young Ju; Lee, Boeun; Ha, Eun–Hee

doi:10.1097/md.0000000000002508

Cited by 67 publications

(41 citation statements)

References 34 publications

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“…However, the data in Matak et al (6), in combination with other studies, create a biological basis for understanding the relationship between body iron status and neurocognitive function in early childhood. In addition to this study, it has been shown that infants who have abnormally low serum ferritin concentrations, an indicator of severe iron deficiency, have defective auditory recognition memory and neurocognitive development (21,22). Low serum ferritin is often seen in infants born to severely anemic mothers (23).…”

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confidence: 99%

A role for iron deficiency in dopaminergic neurodegeneration

Yien

Paw

2016

Proc. Natl. Acad. Sci. U.S.A.

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confidence: 99%

A role for iron deficiency in dopaminergic neurodegeneration

Yien

Paw

2016

Proc. Natl. Acad. Sci. U.S.A.

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“…(4,5,6) , estudo de coorte (7,8) estudos prospectivos (9,10,11) , estudos de comparação (12,13,14,15) , acompanhamento em longo prazo (16) , estudos piloto (17) , longitudinal (18) metanálise (19) . Alguns teóricos apontam que níveis ≥10µg/dL são determinantes para a ocorrência desses danos (9,16,17) .…”

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“…Estudiosos indicam que o possível prejuízo cognitivo pode provir da exposição já no período pré-natal (10,7,4,5,6) , divergente do estudo de Parajuli et al (24) que indica que o Pb presente no período (9) .…”

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Danos cognitivos em crianças contaminadas por chumbo

Ribeiro¹,

Vale²

2017

Rev. Cient. FAEMA

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RESUMO:Este estudo objetivou investigar a literatura a fim de verificar se há relação entre concentrações anormais de chumbo no organismo e danos cognitivos em crianças. Materiais e métodos: uma revisão bibliográfica foi realizada no primeiro semestre de 2017, na base de dados Pubmed de acordo com as combinações, traduzidas do inglês "nível de chumbo, exposição, desenvolvimento cognitivo" e "chumbo, inteligência, envenenamento, desenvolvimento". Os critérios de inclusão para a revisão foram: coerência com a temática proposta; artigos em inglês ou português; artigos originais; e artigos de acesso livre. Foram excluídos da revisão os artigos que não abordassem a temática proposta; artigos com idiomas que não estivessem na língua inglesa ou portuguesa; revisões de literatura; e artigos com acesso pago. Resultados e Discussões: foram encontrados 128 artigos conforme os mecanismos de busca para a combinação "nível de chumbo, exposição, desenvolvimento cognitivo", dos quais apenas 4 atingiram os critérios de inclusão e foram adotados na revisão. E conforme a combinação "chumbo, inteligência, envenenamento, desenvolvimento", foram obtidos 62 resultados, sendo 6 correspondentes aos critérios de inclusão. Destes, apenas 3 foram adotados na revisão. Ressalta-se também que foram incluídas referências citadas por outros autores, sendo encontrado o total de 18 referências citadas. Considerações finais: a partir da literatura analisada, é possível considerar a significativa relação entre a presença de chumbo no organismo de crianças e danos cognitivos, tanto em níveis acima do valor de 10µg/dL recomendados pelo Centro de Controle da Doenças (CDC, sigla em inglês) como abaixo desse valor. Descritores (DeCS

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“…Environmental contaminants, such as tobacco smoke, lead and phthalates, are transferred from mothers to infants transplacentally and via breast milk (Green and Marsit 2015; Dzwilewski and Schantz 2015; Shah-Kulkarni et al 2016; LaKind et al 2008; Kim et al 2014). Research on the impact of environmental toxins on breastfeeding has focused on breast milk as a vehicle of infant exposure.…”

Section: Introductionmentioning

confidence: 99%

Low-Level Prenatal Toxin Exposures and Breastfeeding Duration: A Prospective Cohort Study

Rosen-Carole

Howard

Brownell

et al. 2017

Matern Child Health J

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Introduction Maternal exposure to tobacco smoke is associated with shortened breastfeeding duration, but few studies have examined the effects on breastfeeding outcomes of low level exposures to other toxic chemicals. Moreover, it is unclear if passive smoking is associated with duration of breastfeeding. Our objective was therefore to examine the effect of low-level prenatal exposures to common environmental toxins (tobacco smoke, lead, and phthalates) on breastfeeding exclusivity and duration. Methods We conducted an analysis of data from the HOME (Health Outcomes and Measures of the Environment) Study. Serum and urine samples were collected at approximately 16 and 26 weeks gestation and at delivery from 373 women; 302 breastfed their infants. Maternal infant feeding interviews were conducted a maximum of 8 times through 30 months postpartum. The main predictor variables for this study were gestational exposures to tobacco smoke (measured by serum cotinine), lead, and phthalates. Passive smoke exposure was defined as cotinine levels of 0.015–3.0 μg/mL. Primary outcomes were duration of any and exclusive breastfeeding. Results Serum cotinine concentrations were negatively associated with the duration of any breastfeeding (29.9 weeks unexposed vs. 24.9 weeks with passive exposure, p=0.04; and 22.4 weeks with active exposure, p=0.12; p=0.03 for linear trend), but not duration of exclusive breastfeeding. Prenatal levels of blood lead and urinary phthalate metabolites were not significantly associated with duration of any or exclusive breastfeeding. Conclusions Passive exposure to tobacco smoke during pregnancy was associated with shortened duration of any breastfeeding.

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Neurodevelopment in Early Childhood Affected by Prenatal Lead Exposure and Iron Intake

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Cited by 67 publications

References 34 publications

A role for iron deficiency in dopaminergic neurodegeneration

A role for iron deficiency in dopaminergic neurodegeneration

Danos cognitivos em crianças contaminadas por chumbo

Low-Level Prenatal Toxin Exposures and Breastfeeding Duration: A Prospective Cohort Study

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