2022
DOI: 10.55940/medphar202210
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Neurodevelopmental Abnormalities in Children Associated with Maternal Use of Psychoactive Medication

Abstract: Background: Due to its negative effects on the unborn child and the mother as a consumer, pregnant women's intake of psychoactive substances has become a public health concern. Additionally, consuming these chemicals has been linked to several neurological development changes in children, including behavioral issues (such as attention deficit hyperactivity disorder and autism spectrum disorder), cognitive issues, and sensory and motor function changes. Objectives: To perform a thorough, comprehensive study of… Show more

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Cited by 8 publications
(9 citation statements)
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“…Currently, 13 medications are approved by the European Medicine Agency and Food and Drug Administration as disease-modifying treatments for MS, including IFN-1a (Avonex), IFN-1b (Betaseron or Extavia), glatiramer acetate (Copaxone), natalizumab (Tysabri), fingolimod (Gilenya), and dimethyl fumarate (Tecfi). [9,46–49] Numerous studies have examined the effect of clinical factors (relapses and the development of impairment) and/or MRI activity (defined as either new or expanding T2-lesions relative to baseline MRI scans or new or increased gadolinium-enhancing lesions) to identify disease-modifying treatment responders and non-responders. [50–54] IFN-Bs, glatiramer acetate therapy, teriflunomide, and dimethyl fumarate, are currently recommended by the Middle East and North Africa Committee for Treatment and Research in Multiple Sclerosis guidelines as first-line therapies for RRMS, and fingolimod is a suitable substitute for patients with needle phobia or other contraindications to the aforementioned drugs, for patients with a severely active illness (two or more debilitating relapses in a year associated with MRI abnormalities), fingolimod, natalizumab, or alemtuzumab are recommended as second-line treatments.…”
Section: Resultsmentioning
confidence: 99%
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“…Currently, 13 medications are approved by the European Medicine Agency and Food and Drug Administration as disease-modifying treatments for MS, including IFN-1a (Avonex), IFN-1b (Betaseron or Extavia), glatiramer acetate (Copaxone), natalizumab (Tysabri), fingolimod (Gilenya), and dimethyl fumarate (Tecfi). [9,46–49] Numerous studies have examined the effect of clinical factors (relapses and the development of impairment) and/or MRI activity (defined as either new or expanding T2-lesions relative to baseline MRI scans or new or increased gadolinium-enhancing lesions) to identify disease-modifying treatment responders and non-responders. [50–54] IFN-Bs, glatiramer acetate therapy, teriflunomide, and dimethyl fumarate, are currently recommended by the Middle East and North Africa Committee for Treatment and Research in Multiple Sclerosis guidelines as first-line therapies for RRMS, and fingolimod is a suitable substitute for patients with needle phobia or other contraindications to the aforementioned drugs, for patients with a severely active illness (two or more debilitating relapses in a year associated with MRI abnormalities), fingolimod, natalizumab, or alemtuzumab are recommended as second-line treatments.…”
Section: Resultsmentioning
confidence: 99%
“…Immunoglobulin g (IgG) antibodies can also bind integrin α4β1 (very late antigen-4) and inhibit their migration. [ 9 ]…”
Section: Resultsmentioning
confidence: 99%
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“…And Spirulina sp. By studying the total phenolic content, flavonoids and phycobiliprotein, it was possible to conclude that the four species of cyanobacteria had antioxidant activity [41].…”
Section: Antioxidant Activitymentioning
confidence: 99%