Neuroepithelial Endocrine Cells in the Lung of the Lungfish Protopterus aethiopicus

Adriaensen, Dirk; Scheuermann, D.W.; Timmermans, J.‐P.; Groodt-Lasseel, M.H.A. de

doi:10.1159/000146981

Cited by 33 publications

(14 citation statements)

References 9 publications

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“…The occurrence in the apical cytoplasm of rough endoplasmic reticulum, a Golgi complex, electronlucent vesicles located in close proximity to the Golgi apparatus and just beneath the luminal plasma membrane, as well as coated vesicles are morphological features that are suggestive of a secretory activity on the apical pole of some NEE cells (Haller, 1993). Similar apical vesicles indicating a process of exocytosis were reported in NEE cells of a lungfish (Adriaensen et al, 1990). However, the content of the apical secretory vesicles is as yet undetermined.…”

Section: General Reflectionssupporting

confidence: 77%

Comparative histology of pulmonary neuroendocrine cell system in mammalian lungs

Scheuermann¹

1997

Microsc. Res. Tech.

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It is increasingly recognized that neuroepithelial endocrine cells and organoid clusters of these cells termed neuroepithelial bodies are widely distributed in the respiratory tract of vertebrates. This review focuses on the neuroepithelial endocrine system in the airway epithelium of mammals according to observations made in a wide range of species, as it appears in light and electron microscopy by means of various visualization techniques under normal and experimental conditions. Because there are similarities but also marked differences between species, wherever possible studies in human airways are emphasized. Conventional histochemical and ultrastructural studies including microspectrofluorimetry have demonstrated the amine-handling properties and the presence of neurosecretory granules in neuroendocrine cells of the epithelium of all mammals studies so far. The neuroepithelial bodies are innervated by morphological afferent- and efferentlike synaptic specializations. These, together with the presence of reciprocal synapses, emphasize that these cells may be involved in dual functions of chemoreception and secretion. Light and electron microscopic immunohistochemistry has demonstrated that neuroepithelial endocrine cells may contain various biogenic agents, suggesting that the neuroendocrine system is highly heterogeneous. Neural elements may interact in a complex manner, and the activation of certain neural pathways may control the release of biogenic substances to influence physiological airway functions. They may be particularly relevant in pulmonary diseases. Consequently, the function of this system is complex and it is highly probable that many of its aspects are still not elucidated.

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Section: General Reflectionssupporting

confidence: 77%

Comparative histology of pulmonary neuroendocrine cell system in mammalian lungs

Scheuermann¹

1997

Microsc. Res. Tech.

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“…Similar apical vesicles indicating a process of exocytosis were reported in NEE cells of a lungfish (Adriaensen et al, 1990). However, the content of the apical secretory vesicles is as yet undetermined.…”

Section: General Reflectionssupporting

confidence: 77%

Comparative histology of pulmonary neuroendocrine cell system in mammalian lungs

Scheuermann

1997

Microsc. Res. Tech.

Self Cite

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It is increasingly recognized that neuroepithelial endocrine cells and organoid clusters of these cells termed neuroepithelial bodies are widely distributed in the respiratory tract of vertebrates. This review focuses on the neuroepithelial endocrine system in the airway epithelium of mammals according to observations made in a wide range of species, as it appears in light and electron microscopy by means of various visualization techniques under normal and experimental conditions. Because there are similarities but also marked differences between species, wherever possible studies in human airways are emphasized. Conventional histochemical and ultrastructural studies including microspectrofluorimetry have demonstrated the amine‐handling properties and the presence of neurosecretory granules in neuroendocrine cells of the epithelium of all mammals studied so far. The neuroepithelial bodies are innervated by morphological afferent‐ and efferentlike synaptic specializations. These, together with the presence of reciprocal synapses, emphasize that these cells may be involved in dual functions of chemoreception and secretion. Light and electron microscopic immunohistochemistry has demonstrated that neuroepithelial endocrine cells may contain various biogenic agents, suggesting that the neuroendocrine system is highly heterogeneous. Neural elements may interact in a complex manner, and the activation of certain neural pathways may control the release of biogenic substances to influence physiological airway functions. They may be particularly relevant in pulmonary diseases. Consequently, the function of this system is complex and it is highly probable that many of its aspects are still not elucidated. Microsc. Res. Tech. 37:31–42, 1997. © 1997 Wiley‐Liss, Inc.

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“…The base of the cell contains numerous dense-cored vesicles, 80-165 nm in diameter, and is adjacent to the basement membrane, but appears to lack innervation. The fine structure in Protopterus was described by Adriaensen et al (1990), who demonstrated the presence of neuro-endocrine cells in the pneumatic duct region. The cytology was similar but the dense-cored vesicles somewhat smaller than in Polypterus (30-150 nm) and the neuro-endocrine cells were innervated.…”

Section: Paraneurons In the Lungs Of Air-breathing Fishesmentioning

confidence: 97%

Distribution patterns of the paraneuronal endocrine cells in the skin, gills and the airways of fishes as determined by immunohistochemical and histological methods

1994

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The neuro-endocrine cells of fish skin and respiratory surfaces, and their bioactive secretion as far as is known, are reviewed, and compared with similar elements in tetrapods, particularly amphibians. In the skin of teleost fish, immunohistochemistry has shown that Merkel cells react for serotonin, neuron-specific enolase and enkephalins. The pharmacology is not established in dipnoans or lampreys. In some teleosts, neuromasts react for substance P and leu-enkephalins; substance P is also reported from some ampullary organs (electroreceptors). Taste buds of teleosts may react for enkephalin and substance P. Basal cells of taste buds react for serotonin and neuron-specific enolase. Some unicellular skin glands of teleosts express bioactive compounds, including serotonin and some peptides; this ectopic expression is paralleled in amphibian skin glands. The dipnoan Protopterus has innervated pulmonary neuro-endocrine cells in the pneumatic duct region with dense-cored vesicles. In Polypterus and Amia the lungs have serotonin-positive neuro-endocrine cells that are apparently not innervated. In fish gills, a closed type of neuro-endocrine cell reacts for serotonin, an open type for enkephalins and some calcium-binding proteins (calbindin, calmodulin and S-100 protein). The functions of neuro-endocrine cells in fishes await investigation, but it is assumed they are regulatory.

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Neuroepithelial Endocrine Cells in the Lung of the Lungfish Protopterus aethiopicus

Cited by 33 publications

References 9 publications

Comparative histology of pulmonary neuroendocrine cell system in mammalian lungs

Comparative histology of pulmonary neuroendocrine cell system in mammalian lungs

Comparative histology of pulmonary neuroendocrine cell system in mammalian lungs

Distribution patterns of the paraneuronal endocrine cells in the skin, gills and the airways of fishes as determined by immunohistochemical and histological methods

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