Neurofibromatosis type 1 in children: MR imaging and follow-up studies of central nervous system findings

Menor, Francisco; Martí‐Bonmatí, Luis; Arana, Estanislao; Poyatos, C.; Cortina, H.

doi:10.1016/s0720-048x(97)00088-0

Cited by 45 publications

(31 citation statements)

References 17 publications

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“…There are few reports of non-optic gliomas, which are located in areas other than optic pathways and hypothalamus, commonly in brainstem, with spontaneous regression or involution in the patients with NF. Moreover, very few of these non-optic glial tumors are histologically verified (9,11). Our patient revealed spontaneous involution of a histologically proven pilocytic astrocytoma located in the internal capsule, which is a rare phenomenon.…”

Section: Discussionmentioning

confidence: 62%

“…Like the areas of probable myelin vacuolization and/or hamartomatous changes, the spontaneous disappearance or regression of optic pathwayhypothalamic glial tumors has been reported in many of articles in the literature (6,9,10). There are few reports of non-optic gliomas, which are located in areas other than optic pathways and hypothalamus, commonly in brainstem, with spontaneous regression or involution in the patients with NF.…”

Section: Discussionmentioning

confidence: 95%

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Spontaneous involution of a non‐optic astrocytoma in neurofibromatosis type I: serial magnetic resonance imaging evaluation

Çakırer

Karaarslan

2004

Acta Radiol

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A patient with neurofibromatosis type I (NF1) was followed-up with serial magnetic resonance imaging (MRI) studies over a period of 6 years. A contrast-enhancing lesion of the internal capsule, histologically proven to be pilocytic astrocytoma through stereotactic brain biopsy with mass effect and associated edema, was detected to reveal spontaneous involution on follow-up MRI studies. Although spontaneous regression of gliomas of the optic pathway-hypothalamus in patients with NF1 is relatively common in the literature, spontaneous involution of non-optic (i.e. areas other than optic pathways and hypothalamus) gliomas is rarely reported. Conservative management with follow-up MRI studies should be considered for non-optic glial tumors and tumor-like masses in patients with NF1, and surgical treatment should not be considered unless the lesions exhibit a rapid or unrelenting growth on serial MRI studies or produce significant clinical deterioration.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 95%

Spontaneous involution of a non‐optic astrocytoma in neurofibromatosis type I: serial magnetic resonance imaging evaluation

Çakırer

Karaarslan

2004

Acta Radiol

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“…They represent a vacuolar change of myelin with fluid-containing spaces ranging from 5 to 100 mm in size, which explains the T2 hyperintensity. [10][11][12][13][14][15][16] This peculiar pattern of spongiform myelinopathy caused by abnormal myelin maturation represents the pathologic basis of our study.…”

mentioning

confidence: 99%

Brain Apparent Diffusion Coefficient Evaluation in Pediatric Patients With Neurofibromatosis Type 1

Tognini

Ferrozzi²,

Garlaschi³

et al. 2005

Journal of Computer Assisted Tomography

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“…these benign lesions are characterized by a vacuolar change of myelin referred to as spongiform myelinopathy [83]. However, in a large cohort of 56 NF1 children between 10 months and 14 years with hyperintense lesions, two lesions were considered symptomatic brainstem gliomas [84]. On follow-up, more than two thirds of these infratentorial lesions decreased or remained unchanged in size, whereas only 15.5% increased in size and the rest showed a mixed increased/decreased pattern.…”

Section: Brain Tumorsmentioning

confidence: 99%

MR Imaging of Midbrain Pathologies

et al. 2010

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The spectrum of pathologic processes affecting the midbrain features some differences to other brain areas. The midbrain is exposed to traumatic alterations due to its position between the tentorial edges, and some neurodegenerative and metabolic-toxic diseases may typically involve the midbrain. Isolated midbrain ischemia is rare, whereas the midbrain is typically part of the "top of the basilar" syndrome. Primary midbrain tumors are also infrequent and often show a benign clinical course. Apart from multiple sclerosis other inflammatory autoimmune processes and some infectious agents predominantly affect the brainstem including the midbrain. This review discusses the different pathologic processes of the midbrain, i.e., infarction, hemorrhage and trauma, inflammation, toxic and metabolic diseases, neurodegeneration, neoplastic diseases, as well as pathologies typically involving the perimesencephalic cisterns.

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Neurofibromatosis type 1 in children: MR imaging and follow-up studies of central nervous system findings

Cited by 45 publications

References 17 publications

Spontaneous involution of a non‐optic astrocytoma in neurofibromatosis type I: serial magnetic resonance imaging evaluation

Spontaneous involution of a non‐optic astrocytoma in neurofibromatosis type I: serial magnetic resonance imaging evaluation

Brain Apparent Diffusion Coefficient Evaluation in Pediatric Patients With Neurofibromatosis Type 1

MR Imaging of Midbrain Pathologies

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