Neurogenic pulmonary edema in childhood

Milley, J. Ross; Nugent, Stephen K.; Rogers, Mark C.

doi:10.1016/s0022-3476(79)80134-1

Cited by 23 publications

(7 citation statements)

References 15 publications

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“…NPE has previously been described in children and, as in adults, it is a diagnosis with a grave prognosis (14). It has many potential causes including head trauma, epilepsy, and cerebrovascular accidents (15).…”

Section: Discussionmentioning

confidence: 99%

Neurogenic pulmonary edema in enterovirus 71 encephalitis is not uniformly fatal but causes severe morbidity in survivors

Prager

Nolan

Andrews

et al. 2003

Pediatric Critical Care Medicine

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During the Australian summer of 2000/2001, there was an outbreak of enterovirus 71 infection in Sydney. Between December 2000 and May 2001, approximately 200 children presented to Sydney Children's Hospital with hand-foot-and-mouth disease and 18 experienced neurologic complications. Four presented with acute invasive central nervous system disease and severe pulmonary edema. We describe the cardiorespiratory disturbances and intensive care management of these four consecutive children successfully treated for neurogenic pulmonary edema attributed to proven enterovirus 71 infection. All four survived the acute stage of the illness. However, all four have been left with significant debilitating morbidity. Epidemic enterovirus 71 brainstem encephalitis presenting as neurogenic pulmonary edema can be successfully managed in the pediatric intensive care unit but has great potential to yield a large number of handicapped toddlers and become "the poliomyelitis of the 21st century."

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Section: Discussionmentioning

confidence: 99%

Neurogenic pulmonary edema in enterovirus 71 encephalitis is not uniformly fatal but causes severe morbidity in survivors

Prager

Nolan

Andrews

et al. 2003

Pediatric Critical Care Medicine

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“…Compared with adult patients, NPE is rarely diagnosed in childhood. Head trauma (including cases caused by abuse) and enterovirus 71 infection, are the disorders that are most commonly associated with pediatric NPE [3], [4], [14], [15], [16]. There have been only 7 reports about pediatric cases of NPE that occurred after non-febrile epileptic seizures [5], [6], [7], [8], [9], [10], [11].…”

Section: Discussionmentioning

confidence: 99%

Neurogenic pulmonary edema combined with febrile seizures in early childhood—A report of two cases

Tasaka

Matsubara

Hori

et al. 2016

IDCases

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Neurogenic pulmonary edema (NPE) is a clinical entity that can occur following central nervous system disorders. However, NPE occurs quite rarely in early childhood, and there has only been one report about pediatric NPE associated with febrile seizures. Two cases are reported here. One case involved a 2-year-old girl who presented with febrile seizures, which rapidly progressed to severe NPE. Since the NPE occurred in the emergency department room, the patient was able to be resuscitated via immediate endotracheal intubation. The other case involved an 11-month-old boy who developed respiratory distress following a 50-min episode of febrile status epilepticus. Both patients required respiratory management in the intensive care unit. However their conditions were dramatically improved within several days and fully recovered without any sequelae.

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“…1,2,[4][5][6] The incidence of pulmonary edema in patients with subarachnoid hemorrhage (SAH) has been reported to be between 46% and 52% in postmortem studies 7,8 and anywhere between 2% and 50% in in vivo studies. 12,13 Patients may present with varying degrees of dyspnea, tachypnea, and cyanosis shortly after experiencing the brain insult and correlative radiographic findings may confirm the diagnosis (Fig. 11 Although the incidence of NPE is believed to be significantly lower in children than in adults, 4 it remains an often unrecognized diagnosis in the pediatric population.…”

Section: Discussionmentioning

confidence: 99%