Neuroimaging findings of postnatally acquired Zika virus infection: a pictorial essay

Mehrjardi, Mohammad Zare; Carteaux, Guillaume; Poretti, Andrea; Taheri, Morteza Sanei; Bermúdez, Sonia; Werner, Heron; Cruz, Luiz Celso Hygino da

doi:10.1007/s11604-017-0641-z

Cited by 25 publications

(19 citation statements)

References 17 publications

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“…Spinal cord involvement in ZIKV can vary, and previous reports have described different forms of involvement. 11,17,27,28 Clinical symptoms are diverse and depend on the location and extension of the lesion. We can speculate that ZIKV might also specifically affect the anterior horns of the spinal cord (Fig 3), leading to a motor neuron syndrome, similar to the West Nile virus.…”

Section: Neurologic Disorders Associated With Zika Virus Infection Inmentioning

confidence: 99%

“…26 Other forms of spinal involvement have been described, such as those present in acute transverse myelitis, which usually involves the spinal cord in Ͼ3 segments lengthwise and more than two-thirds of its surface area. 17,28 Myelitis can also be identified as diffuse lesions with varying sizes that may affect any portion of the spinal cord. Contrast enhancement may be seen in acute lesions.…”

Section: Neurologic Disorders Associated With Zika Virus Infection Inmentioning

confidence: 99%

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Neuroimaging Findings of Zika Virus–Associated Neurologic Complications in Adults

Cruz

Nascimento

Lopes

et al. 2018

AJNR Am J Neuroradiol

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When the first suspected cases of neurologic disorders associated with the Zika virus were noticed in Brazil in late 2015, several studies had been conducted to understand the pathophysiology of the disease and its associated complications. In addition to its well-established association with microcephaly in neonates, the Zika virus infection has also been suggested to trigger other severe neurologic complications in adults, such as Guillain-Barré syndrome, radiculomyelitis, and meningoencephalitis. Hence, the Zika virus should be deemed a global threat that can cause devastating neurologic complications among individuals in all age ranges. The aim of this review was to further describe neuroimaging findings of Zika virus infection and associated neurologic complications found in adults.

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Section: Neurologic Disorders Associated With Zika Virus Infection Inmentioning

confidence: 99%

Section: Neurologic Disorders Associated With Zika Virus Infection Inmentioning

confidence: 99%

Neuroimaging Findings of Zika Virus–Associated Neurologic Complications in Adults

Cruz

Nascimento

Lopes

et al. 2018

AJNR Am J Neuroradiol

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“…Other rare neurological manifestations of postnatal ZIKV infection, such as myelitis/myelopathy, meningoencephalitis, optic neuropathy, sensorineural hearing loss, and unspecified polyneuropathy, have been associated with ZIKV infection, reflecting the virus affinity for nervous tissues even in postnatal infections. In some cases, ZIKV seems to persist for longer periods in serum when a neurological manifestation is present …”

Section: Guillain‐barré Outbreak In Mid‐2015 and Other Postnatal Neurmentioning

confidence: 99%

Untold stories of the Zika virus epidemic in Brazil

Avelino‐Silva

Kallas

2018

Reviews in Medical Virology

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The Zika virus infection outbreak in Brazil in 2014 to 2015 resulted in the identification of previously unknown consequences of the disease, including the notorious microcephaly among many defects in fetuses born to women infected during pregnancy. A number of individuals were involved in this remarkable discovery, from the detection of viral circulation in the country to the studies on the causal link with congenital abnormalities and the provision of awareness and social support to families affected by the disease. In this article, we review the background to this experience, describing aspects of the epidemiology, medical research, and scientific response to the Zika virus outbreak in Brazil.

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“…There are many pieces of evidence for the close relationship between the GBS and ZIKV infection [4,12]. Some other neurologic complications such as meningoencephalitis, acute disseminated encephalomyelitis, acute myelitis, and transverse myelitis have been reported during ZIKV infection [12,[48][49][50].…”

Section: Clinical Features and Differential Diagnosismentioning

confidence: 99%

Global Alert: Zika Virus-an Emerging Arbovirus

Özkurt¹,

Tanrıverdi²

2017

Eurasian J Med

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Zika virus (ZIKV) is an arbovirus of the Flavivirus genus, and it has an envelope and a single RNA molecule. In early 2016, the World Health Organization declared ZIKV infection to be an emerging global health threat. The major transmission route of the virus to humans is Aedes mosquitoes. ZIKV can be transmitted between humans by transplacental, perinatal, and sexual routes and via blood and body fluids. ZIKV infection usually results in a mild and self-limiting disease with low-grade fever, conjunctivitis, and periorbital edema. Neurological complications such as Guillain-Barré syndrome, meningoencephalitis, acute disseminated encephalomyelitis, acute myelitis, and transverse myelitis have been reported during ZIKV infection. Intrauterine and congenital ZIKV infections have strong teratogenic effects on the fetus. Intrauterine or congenital ZIKV infection can lead to microcephaly, ocular anomalies (such as macular atrophy, pigment mottling, and optic nerve anomalies), and cardiac anomalies (such as atrial or ventricular septal defect). Calcification in the brain between the cortical and subcortical areas, ventriculomegaly, cerebellar hypoplasia, corpus callosum hypoplasia, cortical/subcortical atrophy, delayed myelination, enlarged cisterna magna, and craniofacial disproportion have been reported as brain development defects. ZIKV infection usually results in a mild disease, and it does not require specific therapy. However, complications of infection during the early period of life are serious. Thus, many drugs have been investigated, and vaccine development studies have been conducted to prevent ZIKV infection. Vector control and personal protection from mosquito-borne transmission are important for decreasing the prevalence of ZIKV infection. In particular, pregnant residents or travelers to endemic areas should be carefully protected against mosquito-borne transmission.Keywords: Zika virus, Flavivirus, microcephaly, Guillain-Barré Syndrome, aedes, arbovirus ÖZ Zika virus (ZIKV), Flavivirus ailesinden sivrisineklerle bulaşan zarflı ve tek sarmallı RNA'ya sahip bir arbovirusdur. 2016 yılı başında Dünya Sağlık Örgütü (DSÖ) ZIKV enfeksiyonunun giderek önemi artan bir küresel tehdit olduğunu açıklamıştır. Virusun insanlara esas geçiş yolu Aedes tipi sivrisineklerin ısırmasıdır. İnsanlar arasında transplasental, perinatal, cinsel yolla, ayrıca kan ve vücut sıvıları aracılığı ile bulaşır. ZIKV enfeksiyonu genellikle hafif ve kendini sınırlandıran hastalık olup, düşük derecede ateş, konjuktivit ve periorbital ödem ile seyreder. ZIKV enfeksiyonu esnasında Guillain-Barre sendromu, meningoensefalit, akut dissemine ensefalomyelit (ADEM), akut myelit, transvers myelit gibi nörolojik komplikasyonlar rapor edilmiştir. Intrauterin ve konjenital ZIKV enfeksiyonu fetus üzerinde ağır teratojenik etkiye sahiptir. İntrauterin enfeksiyon mikrosefali, oküler anomaliler (maküler atrofi, pigment beneklenmesi ve optik sinir anomalileri gibi) ve kardiyak anomalilere (atrial veya ventriküler septal defekt gibi) yol açabilir. ...

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Neuroimaging findings of postnatally acquired Zika virus infection: a pictorial essay

Cited by 25 publications

References 17 publications

Neuroimaging Findings of Zika Virus–Associated Neurologic Complications in Adults

Neuroimaging Findings of Zika Virus–Associated Neurologic Complications in Adults

Untold stories of the Zika virus epidemic in Brazil

Global Alert: Zika Virus-an Emerging Arbovirus

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