Neurologic Outcomes of Survivors of COVID-19–Associated Acute Respiratory Distress Syndrome Requiring Intubation

Jaquet, Pierre; Legouy, Camille; Fèvre, Lucie Le; Grinea, Alexandra; Sinnah, Fabrice; Franchineau, Guillaume; Patrier, Juliette; Marzouk, Mehdi; Wicky, Paul-Henri; Geoffroy, Pierre A.; Arnoult, Florence; Vledouts, Serafima; Montmollin, Étienne de; Bouadma, Lila; Timsit, Jean‐François; Sharshar, Tarek; Sonneville, Romain

doi:10.1097/ccm.0000000000005500

Cited by 11 publications

(20 citation statements)

References 38 publications

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“…We read with great interest the innovative study published in a recent issue of Critical Care Medicine by Jaquet et al (1), evaluating long-term neurologic prognosis of survivors of COVID-19–associated acute respiratory distress syndrome (ARDS). They report functional disability in 61% and cognitive impairment in 52% of survivors 4 months after ICU discharge.…”

Section: To the Editormentioning

confidence: 99%

Neuro-Psychological Outcome of ICU-Admitted COVID-19 Patients Presenting With CNS Complications

Pelle

Nedelec

Marois

2023

Critical Care Medicine

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Section: To the Editormentioning

confidence: 99%

Neuro-Psychological Outcome of ICU-Admitted COVID-19 Patients Presenting With CNS Complications

Pelle

Nedelec

Marois

2023

Critical Care Medicine

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“…In another study with patients requiring intubation due to COVID-19, neurologic outcomes were investigated 3 and 6 months after ICU discharge. Cognitive impairment, muscle weakness, and psychologic symptoms were frequent and 74% still required follow-up interventions like physiotherapy or neuropsychological therapy ( 8 ). These cases emphasize the necessity of neurorehabilitation in most cases ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

Critical COVID-19 disease: Clinical course and rehabilitation of neurological deficits

Wimmer

Egger²,

Bergmann³

et al. 2022

Front. Neurol.

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BackgroundThe COVID-19 disease frequently causes neurological symptoms. Critically ill patients often require neurorehabilitation for manifestations like intensive care unit (ICU) acquired weakness or encephalopathy. The outcome of these patients, however, is largely unknown. Here we report the clinical course of critical affected COVID-19 patients from hospital admission to discharge from inpatient neurorehabilitation.MethodsProspective cohort study. COVID-19 patients admitted to neurorehabilitation were included based on a laboratory-confirmed SARS-CoV-2 infection. Assessments [modified Rankin Scale (mRS), Barthel-Index, Fatigue-Severity-Scale-7 and health-related quality of life (EQ-5D-5L)] were conducted at admission and before discharge from inpatient care. Data were compared to the preclinical health status.ResultsSixty-one patients (62 ± 13 years, 16 female) were included in the analysis. Most patients had been treated on ICU (n = 58; 57 ± 23 days) and had received invasive ventilation (n = 57; 46 ± 21 days). After discharge from ICU, patients spent on average 57 ± 26 days in neurorehabilitation. The most frequent neurological diagnoses were ICU-acquired weakness (n = 56) and encephalopathy (n = 23). During rehabilitation overall disability improved [mRS median (IQR) 4.0 (1.0) at inclusion and 2.0 (1.0) at discharge]. However, the preclinical health state [mRS 0.0 (0.0)] was not regained (p < 0.001). This was also reflected by the Barthel-Index [preclinical 100.0 (0.0), at inclusion 42.5 (35.0), at discharge 65.0 (7.5); p < 0.001]. Patients had only minor fatigue during inpatient care. Quality of life generally improved but was still low at discharge from hospital.ConclusionPatients with neurological sequelae after critical COVID-19 disease showed substantial deficits at discharge from inpatient care up to 4 months after the initial infection. They were restricted in activities of daily living and had reduced health-related quality of life. All patients needed continued medical support and physical treatment.

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“…A síndrome da tempestade de citocinas devido á COVID-19 pode levar a complicações neurocognitivas, afetando as habilidades de memória 20,21 , atenção e velocidade de processamento, propondo-se reabilitação neurológica objetivando reduzir os as consequências dessas alterações, bem como o risco cognitivo relacionado à idade, semelhante às pesquisas que foram analisadas nos estudos da presente pesquisa, realizados com pacientes que estavam em reabilitação e incluíam pessoas idosas 6,13 20 . Em pacientes que necessitaram de intubação devido a síndrome do desconforto respiratório agudo, observou-se incapacidade cognitiva funcional leve a grave em cerca de 60% dos sobreviventes 4 meses após a alta da UTI 22 .…”

Section: Historicamente Em Surtos Virais Como Síndromeunclassified

Alterações cognitivas decorrentes da COVID-19: uma revisão sistemática

Guesser

Paiva

Barros³

et al. 2022

Rev Neurocienc

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Introdução. A COVID-19 demonstrou alto potencial de mortalidade e inflamação multissistêmica e, ao afetar o sistema nervoso, pode acarretar déficits cognitivos em todos os estágios da doença, bem como após a recuperação. Objetivo. Verificar as alterações cognitivas em indivíduos diagnosticados com a COVID-19. Método. As buscas por artigos científicos ocorreram nas bases de dados eletrônicos MEDLINE (Pubmed), LILACS, SciELO, SCOPUS, WEB OF SCIENCE e BIREME, sem restrições de localização, no período de 2020 a 2022. Os critérios de seleção incluíram estudos sobre a relação entre COVID-19 e alterações cognitivas em adultos e idosos com idade a partir de 18 anos, e, foram excluídas cartas ao editor, diretrizes, revisões de literatura, revisões narrativas, revisões sistemáticas, metanálises, resumos, relatos e séries de casos. Resultados. Foram 11 estudos incluídos, sendo sete do tipo transversal e quatro do tipo caso-controle. Cinco pesquisas foram realizadas em pacientes hospitalizados e seis em pacientes não hospitalizados e/ou recuperados da doença. Dez apontam para associação positiva entre COVID-19 e déficits cognitivos e um não demonstrou associação. Conclusão. A COVID-19 está associada a déficits cognitivos na fase aguda ou após recuperação, independentemente do grau de severidade e do status de hospitalização. As principais funções cognitivas observadas foram alteração de atenção, memória, linguagem, funções executivas e velocidade de processamento.

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Neurologic Outcomes of Survivors of COVID-19–Associated Acute Respiratory Distress Syndrome Requiring Intubation

Abstract: To describe 3-6-month neurologic outcomes of survivors of COVID-19-associated acute respiratory distress syndrome, invasively ventilated in the ICU. DESIGN:A bicentric prospective study during the two first waves of the pandemic (March to May and September to December, 2020).

Cited by 11 publications

References 38 publications

Neuro-Psychological Outcome of ICU-Admitted COVID-19 Patients Presenting With CNS Complications

Neuro-Psychological Outcome of ICU-Admitted COVID-19 Patients Presenting With CNS Complications

Critical COVID-19 disease: Clinical course and rehabilitation of neurological deficits

Alterações cognitivas decorrentes da COVID-19: uma revisão sistemática

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