Neurological complications of peripheral and cutaneous T‐cell lymphomas

Kaufman, David K.; Habermann, Thomas M.; Kurtin, Paul J.; O’Neill, Brian Patrick

doi:10.1002/ana.410360411

Cited by 43 publications

(28 citation statements)

References 26 publications

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“…In addition, the cohort of Vergier et al, 17 with MF and LCT, had a higher than expected percentage of CNS metastasis (5%) compared with the less than 1.6% incidence established by several large MF cohorts. 3,4 Therefore, patients with MF and LCT appear to be at greater risk of CNS involvement than do patients without LCT.…”

Section: Discussionmentioning

confidence: 99%

“…1 The incidence of central nervous system (CNS) involvement in MF was reported to be 14% in a large autopsy series 2 ; however, the incidence in several large clinical cohorts is less than 1.6%. 3,4 Although 50 cases of CNS involvement in patients with MF have been published [4][5][6] there are only 5 case reports describing CNS involvement in association with large-cell transformation (LCT). 5,7-10 MF is associated with histologic LCT in 8% to 55% of all cases.…”

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confidence: 99%

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Central nervous system involvement in patients with mycosis fungoides and cutaneous large-cell transformation

Duvic

2008

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Central nervous system involvement in patients with mycosis fungoides and cutaneous large-cell transformation

Duvic

2008

Journal of the American Academy of Dermatology

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“…NHL is by far the most common cause of lymphomatous neuropathy syndromes (Table 1). 3,24,64,100 Some of these are associated with HIV infections or other disorders that depress the immune system. 42,114,150 These neoplasms can infiltrate cranial nerves, 38,45,97 roots, 100 plexuses, 62,71,123 and peripheral nerves, often ex-tending from regional foci of disease or by hematogenous dissemination.…”

Section: Neurological Syndromes In Individual Lymphomasmentioning

confidence: 99%

Lymphoma and peripheral neuropathy: A clinical review

2004

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Lymphoma occasionally affects the peripheral nervous system. When it does, the diagnosis can be elusive since many patients present without known lymphoma. Most peripheral nerve complications are due to non-Hodgkin's lymphoma (NHL), which infiltrates nerves causing axonal damage. This disorder can affect nerve roots and cranial nerves, often associated with lymphomatous meningitis. NHL may also infiltrate peripheral nerves and cause plexopathy, mononeuropathy, or generalized neuropathy. These neuropathies may resemble an asymmetric mononeuropathy multiplex or a generalized disorder such as chronic inflammatory demyelinating polyradiculoneuropathy. When NHL infiltrates diffusely, the term neurolymphomatosis is used. Hodgkin's lymphoma (HL), by contrast, rarely infiltrates nerves. More often, HL causes immunological disorders of the peripheral nervous system such as inflammatory plexopathy or Guillain-Barré syndrome. Other rare lymphomas such as intravascular lymphoma and Waldenstrom's macroglobulinemia can also affect peripheral nerves in specific ways. In addition, other malignant and nonmalignant lymphoproliferative disorders enter into the differential diagnosis of lymphomatous neuropathy. This review discusses the multiple peripheral nerve presentations of lymphoma from the clinician's point of view and provides a guide to the evaluation and diagnosis of these uncommon, challenging disorders.

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“…Nos estudos anteriores, baseados somente em pacientes com manifestações neurológicas decorrentes do comprometimento do sistema nervoso pelo LNH ou dados de exames complementares ou achados de biópsia ou necropsia, verificaram-se as maiores porcentagens dos sinais e sintomas neurológicos: dor tóraco-lombar, cefaléia, alucinação, rebaixamento do nível de consciência, comprometimento dos nervos cranianos e diminuição da força muscular nos membros [18][19][20][21] .…”

Section: Discussionunclassified

Avaliação neurológica de pacientes adultos com linfoma não-Hodgkin: estudo prospectivo

Mielli¹,

Livramento²

1998

Arq. Neuro-Psiquiatr.

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RESUMO -Estudo prospectivo incluindo 67 pacientes adultos com linfoma não-Hodgkin, considerados segundo o "Working Formulation". A população foi estudada como um todo, quer apresentasse ou não anticorpos anti-HIV no soro. Todos os pacientes foram submetidos a avaliação neurológica e o exame do líquido cefalorraqueano (LCR) foi realizado em 63 deles. Os achados neurológicos e do exame do LCR foram correlacionados. Mostraramse significativas as associações: dor tóraco-lombar localizada e alterações do LCR (presença de células neoplásicas, aumento da concentração proteica e/ou aumento do teor de globulinas gama); anormalidade da força muscular nos membros inferiores e alterações do LCR nos pacientes HIV soro-negativos. Houve correlação entre o aparecimento de sinais de comprometimento dos nervos cranianos III, IV e VI e a detecção de células neoplásicas no LCR.PALAVRAS-CHAVE: linfoma não-Hodgkin, manifestações neurológicas, líquido cefalorraqueano. Neurologic evaluation of non-Hodgkin's lymphoma in adult patients: a prospective studyABSTRACT -This prospective study included 67 adult patients with low, intermediate or high malignancy degrees of non-Hodgkin' s lymphomas according to the Working Formulation. Patients with or without anti-HIV antibodies in the serum were considered. All patients were submitted to neurologic evaluation, and 63 of them to examination of the cerebrospinal fluid (CSF). Patients presenting neurologic signs and symptoms were 42 (62.7%). Neurologic findings and CSF changes were correlated. The association of localized thoraco-lumbar pain and CSF changes (presence of neoplastic cells, increased protein concentration and/or increased gamma globulin content) was statistically significant, as the association of abnormal muscle strength in the lower limbs and CSF changes in patients without HIV antibodies in the serum. Cranial nerve dysfunction (III, IV and VI cranial nerves) correlated with the finding of neoplastic cells in the cerebrospinal fluid.KEY WORDS: non-Hodgkin's lymphoma, neurologic manifestations, cerebrospinal fluid.A elaboração desta pesquisa surgiu do interesse que desperta a relação entre os sistemas nervoso, imunológico e endócrino [1][2][3][4] . Neste contexto podem ser incluídos tanto os linfomas não-Hodgkin (LNH) como neoplasias originadas no sistema imunológico 5 . A oportunidade deste estudo pode creditar-se, pelo menos em parte, ao aumento na incidência desses linfomas com o advento da síndrome da imunodeficiência adquirida (SIDA) 6 .Com o desenvolvimento de terapias mais agressivas e eficazes, houve aumento da sobrevida dos pacientes com neoplasias. Isto passou a exigir participação mais ativa do neurologista. A precisão no diagnóstico é essencial, por permitir estabelecer tratamento adequado e eficaz [7][8][9]

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Neurological complications of peripheral and cutaneous T‐cell lymphomas

Cited by 43 publications

References 26 publications

Central nervous system involvement in patients with mycosis fungoides and cutaneous large-cell transformation

Central nervous system involvement in patients with mycosis fungoides and cutaneous large-cell transformation

Lymphoma and peripheral neuropathy: A clinical review

Avaliação neurológica de pacientes adultos com linfoma não-Hodgkin: estudo prospectivo

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