Neuropathy secondary to vitamin E deficiency in acquired intestinal malabsorption

Palmucci, L.; Doriguzzi, C.; Orsi, Laura; Troni, W.; Angelis, Simona De; Belliardo, Flavio

doi:10.1007/bf02337015

Cited by 9 publications

(8 citation statements)

References 19 publications

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“…The role of vitamin E deficiency in neuromuscular disorders is supported by the consistent stabilization or improvement in symptoms and electrophysiological findings6, 14, 17, 24 following correction of vitamin E deficiency. In patients with fat malabsorption, early therapy with vitamin E delays, and may even prevent, the development of neurological complications 19, 28.…”

Section: Discussionmentioning

confidence: 96%

“…Electrophysiological studies usually demonstrate absent or low‐amplitude sensory nerve action potentials. Motor nerve conduction studies are typically normal,4, 9–11 but reduced CMAP amplitude and mildly slowed conduction velocity have been reported 12, 14, 24. Needle electromyography is normal or shows changes suggestive of mild denervation.…”

Section: Discussionmentioning

confidence: 98%

“…The various neurological disorders associated with vitamin E deficiency are spinocerebellar degeneration,10, 11, 26 polyneuropathy,6, 15, 24 dysautonomia,3 myopathy,5, 23, 34 bulbar palsy,16 myoclonic dystonia,2 and seizures 22. Vitamin E deficiency has also been reported with Werdnig–Hoffmann disease30 and Bassen–Kornzweig syndrome 31.…”

Section: Discussionmentioning

confidence: 99%

“…Prolonged distal latency, slowed conduction velocity, and delayed F response in the median nerve, suggestive of demyelinating neuropathy, are described 6. A recurrent remittent course of neuropathy has also been described 24…”

Section: Discussionmentioning

confidence: 99%

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Isolated vitamin E deficiency with demyelinating neuropathy

et al. 2005

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A 22-year-old man, with a past history of generalized tonic-clonic seizures treated with phenobarbital, presented with spinocerebellar ataxia. The electrophysiological studies revealed a demyelinating motor-sensory neuropathy. The serum vitamin E level was low. Sural nerve biopsy revealed loss of large myelinated fibers with evidence of remyelination. Vitamin E supplementation led to clinical and electrophysiological recovery of sensory conduction and evoked potentials. Motor nerve conduction, however, showed only partial recovery. Vitamin E deficiency leading to a demyelinating neuropathy, as in the present case, suggests that the full spectrum of the disease entity is not fully defined.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Isolated vitamin E deficiency with demyelinating neuropathy

et al. 2005

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“…The latter is seen in several forms of hypo-or abetalipoproteinemia (see Chapter 20). In addition to central nervous system disorders such as spinocerebellar degeneration, myoclonic dystonia and seizures, polyneuropathy has been regularly reported [29][30][31].…”

Section: Vitamin E Deficiencymentioning

confidence: 99%

Neuropathies in malnutrition and alcoholism

Lammens

2014

Peripheral Nerve Disorders

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Nutritional neuropathies

Gwathmey

Grogan

2019

Muscle and Nerve

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Neuropathies associated with nutritional deficiencies are routinely encountered by the practicing neurologist. Although these neuropathies assume different patterns, most are length‐dependent, sensory axonopathies. Cobalamin deficiency neuropathy is the exception, often presenting with a non–length‐dependent sensory neuropathy. Patients with cobalamin and copper deficiency neuropathy characteristically have concomitant myelopathy, whereas vitamin E deficiency is uniquely associated with a spinocerebellar syndrome. In contrast to those nutrients for which deficiencies produce neuropathies, pyridoxine toxicity results in a non–length‐dependent sensory neuronopathy. Deficiencies occur in the context of malnutrition, malabsorption, increased nutrient loss (such as with dialysis), autoimmune conditions such as pernicious anemia, and with certain drugs that inhibit nutrient absorption. When promptly identified, therapeutic nutrient supplementation may result in stabilization or improvement of these neuropathies.

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Neuropathy secondary to vitamin E deficiency in acquired intestinal malabsorption

Cited by 9 publications

References 19 publications

Isolated vitamin E deficiency with demyelinating neuropathy

Isolated vitamin E deficiency with demyelinating neuropathy

Neuropathies in malnutrition and alcoholism

Nutritional neuropathies

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