Neuropharmacological Profile of Gamma-Decanolactone on hemically-induced Seizure in Mice

Pflüger, Pricila; Coelho, Vanessa Rodrigues; Regner, Gabriela Gregory; Silva, Lucas Lima da; Martinez, K. V.; Fonseca, Allex Jardim da; Viau, Cassiana Macagnan; Pereira, Patrícia

doi:10.2174/1871524918666180611103802

Cited by 8 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gama-decanolactone has neuroprotective effect against seizures induced by isoniazid and 4-aminopyridine, but not by picrotoxin. These results suggest a possible modulation of GABA pathways and potassium channels directly or indirectly [212]. In the pilocarpine-induced status epilepticus, gamma-decanolactone at a dose of 300 mg/kg increased the latency to the first clonic seizure, but not there was no statistical difference in the group who received a dose of 100 mg/ kg compared with the control group.…”

Section: Gamma-decanolactonementioning

confidence: 71%

See 1 more Smart Citation

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

et al. 2019

View full text Add to dashboard Cite

Epilepsy is a most disabling neurological disorder affecting all age groups. Among the various mechanisms that may result in epilepsy, neuronal hyperexcitability and oxidative injury produced by an excessive formation of free radicals may play a role in the development of this pathology. Therefore, new treatment approaches are needed to address resistant conditions that do not respond fully to current antiepileptic drugs. This paper reviews studies on the anticonvulsant activities of essential oils and their chemical constituents. Data from studies published from January 2011 to December 2018 was selected from the PubMed database for examination. The bioactivity of 19 essential oils and 16 constituents is described. Apiaceae and Lamiaceae were the most promising botanical families due to the largest number of reports about plant species from these families that produce anticonvulsant essential oils. Among the evaluated compounds, β-caryophyllene, borneol, eugenol and nerolidol were the constituents that presented antioxidant properties related to anticonvulsant action. These data show the potential of these natural products as health promoting agents and use against various types of seizure disorders. Their properties on oxidative stress may contribute to the control of this neurological condition. However, further studies on the toxicological profile and mechanism of action of essential oils are needed.

show abstract

Section: Gamma-decanolactonementioning

confidence: 71%

“…Prolong the latency to the first seizure Decreased the percentage of seizures Male CF1 mice [212] Pilocarpine-Induced Seizure Test Prolonged the latency to first clonic seizure and reduced oxidative stress Male CF1 mice…”

Section: Isoniazid- Picrotoxin-and 4aminopyridine-induced Seizure Testmentioning

confidence: 99%

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The neuroprotective and anti-convulsant effects of gammadecanolactone in the in vivo and in vitro studies have been previously reported (Coelho et al, 1997;De Oliveira et al, 2008;Pflüger et al, 2016Pflüger et al, , 2018aPflüger et al, , 2018bPflüger et al, , 2018b. The potential interrelation between epilepsy and neurodegenerative diseases, as Parkinson's disease, is present in the scientific literature (Deuel et al, 2019;Gruntz et al, 2018;Murata et al, 2007;Scorza et al, 2018a;Son et al, 2016;Vercueil, 2000).…”

Section: Discussionmentioning

confidence: 95%

“…It has been previously described that gamma-decanolactone (GD), Fig. 1, is effective on blocking acute or chronic seizures, induced by different chemical agents in mice (Coelho et al, 1997;De Oliveira et al, 2008;Pflüger et al, 2018aPflüger et al, , 2018b.…”

Section: Introductionmentioning

confidence: 99%

“…The gamma-decanolactone was able to dose-dependently inhibit the specific binding of L-[ 3 H]-glutamate, it has a possible implication in the modulation of the glutamic acid decarboxylase (GAD) enzyme, and it acts on K + channels, leading to a reduction in excitotoxicity. Also, it decreases the expression of inducible nitric oxide synthase (iNOS) and tumor necrosis factor alpha (TNF-α) in microglial cells and consequently inhibits the formation of reactive oxygen species (ROS) (Pereira et al, 1997;Pflüger et al, 2016;2018b). Also, it blocks apoptosis markers such as p38 phosphorylation and the activation of cleaved caspase-9, decreasing deoxyribonucleic acid (DNA) damage, demonstrating that its neuroprotective therapeutic potential comes from inhibiting neuroinflammation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gamma-decanolactone: Preliminary evaluation as potential antiparkinsonian drug

Pflüger

Pereira

Loza

et al. 2021

European Journal of Pharmacology

View full text Add to dashboard Cite

Gamma‐Decanolactone Increases Stress Resistance and Improves Toxicity Parameters on the Caenorhabditis elegans Alternative Model

Campos,

Santos,

Uczay

et al. 2024

J of Applied Toxicology

View full text Add to dashboard Cite

Gamma‐decanolactone (GD) is a monoterpene compound with anticonvulsant, antiparkinsonian, and neuroprotective effects in preclinical trials. This study aimed to evaluate the toxicity and antioxidant profile of GD in silico and in the Caenorhabditis elegans (C. elegans) experimental model. The C. elegans was used to determine the median lethal concentration (LC50) of GD, as well as its effect on survival, development, reproduction, pharyngeal pumping, and stress resistance assays. The in silico study did not indicate hepatotoxic, cardiotoxic, or mutagenic potential to GD. It reduced the worms' survival, both at the L1 and L4 stages, in a concentration‐dependent manner with an LC50 value of 212.16 ± 5.56 μmol/mL. GD did not alter the development, reproduction, and pharyngeal pumping under normal experimental conditions in the three concentrations tested (25, 50, and 100 μmol/mL). In the thermal stress assay, GD did not change the survival pattern of the worms. Hydrogen peroxide (H2O2) reduced the survival of C. elegans and decreased the number of pharyngeal pumping, with these effects being reversed by GD. Also, GD presents an antioxidant activity by modulation the expression of the stress response genes such as sod‐3, ctl‐1,2,3, and gst‐4. In conclusion, GD showed low toxicity in the C. elegans model and antioxidant profile both in the in silico study and in vivo assays.

show abstract

Neuropharmacological Profile of Gamma-Decanolactone on hemically-induced Seizure in Mice

Cited by 8 publications

References 0 publications

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

Gamma-decanolactone: Preliminary evaluation as potential antiparkinsonian drug

Gamma‐Decanolactone Increases Stress Resistance and Improves Toxicity Parameters on the Caenorhabditis elegans Alternative Model

Contact Info

Product

Resources

About