Neurophysiological Findings and Drinking Levels in High‐Alcohol‐Drinking (HAD) and Low‐Alcohol‐Drinking (LAD) Rats

Cj, Slawecki; Betancourt, Michelle; Tk, Li; Cl, Ehlers

doi:10.1111/j.1530-0277.2000.tb04566.x

Cited by 15 publications

(3 citation statements)

References 61 publications

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“…It is unknown if this relationship extends to other rodent lines because ethanol drinking and immobility are not related in all rat lines selectively bred for differential ethanol preference (Godfrey et al, 1997). For example, High Alcohol Drinking (HAD) rats and Low Alcohol Drinking (LAD) rats differ in limited access ethanol intake (Badia-Elder, Stewart, Powrozek, Murphy, & Li, 2003; Samson et al, 1998; Slawecki, Betancourt, Li, & Ehlers, 2000). However, HAD and LAD rats do not exhibit differences in immobility in the FST (Godfrey et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Increased alcohol drinking in isolate-housed alcohol-preferring rats.

Ehlers

Walker

Pian

et al. 2007

Behavioral Neuroscience

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Alcoholism is a complex disorder influenced by interactions between genetic and environmental risk factors. This study examined the influence of isolate housing on ethanol intake in alcohol-preferring (P) and non-alcohol-preferring (NP) rats. Rats were isolate-housed or pair-housed for 8 weeks when between 45 and 96 days old. Ethanol drinking was assessed using a 24-hr preference test (10% ethanol vs. water) and 20-min limited access tests. A behavioral test battery was used to assess anxiety-like, depressive-like, acoustic startle, and motor behavior. Isolate housing increased home cage drinking in both lines and increased limited access drinking selectively in P rats. Isolation also reduced swim test immobility and prepulse inhibition in P rats and increased locomotor stereotypies in NP rats. Taken together, these data demonstrate that LinexEnvironment interactions influence the effects of isolation. Furthermore, isolation selectively increased ethanol intake in high drinking P rats. This effect was not correlated with changes in other behaviors. Selective enhancement of limited access ethanol drinking in P rats may represent a model whereby genetic liability to excessive drinking is enhanced by specific environmental exposures.

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Section: Discussionmentioning

confidence: 99%

Increased alcohol drinking in isolate-housed alcohol-preferring rats.

Ehlers

Walker

Pian

et al. 2007

Behavioral Neuroscience

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“…Surgical coordinates were obtained from the Paxinos and Watson (1986) atlas. For the purpose of comparison with our previous studies in cortical ERPs (Slawecki et al., 2000a), screw electrodes were placed in the skull overlying the frontal cortex [anterior‐posterior (AP): +1.5 mm, mid‐lateral (ML): ± 3.0 mm] and parietal cortex (AP: −4.5 mm, ML: ±4.5 mm) in adult rats and the frontal cortex (AP: +1.5 mm, ML: ±2.0 mm) and parietal cortex (AP: −4.0 mm, ML: ±3.5 mm) in adolescent rats. The stereotaxic coordinates for adolescent rats were based on our previous studies which resulted in placement overlaying the same cortical areas, i.e, frontal cortex 1/frontal cortex 2 and parietal cortex 1 (Slawecki et al., 2006).…”

Section: Methodsmentioning

confidence: 99%

Differential Effects of Acute Alcohol on Prepulse Inhibition and Event‐Related Potentials in Adolescent and Adult Wistar Rats

Pian

Criado

Ehlers

2008

Alcoholism Clin & Exp Res

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Background-Previous studies have demonstrated that adolescent and adult rats show differential sensitivity to many of the acute effects of alcohol. We recently reported evidence of developmental differences in the effects of acute alcohol on the cortical electroencephalogram (EEG). However, it is unclear whether developmental differences are also observed in other neurophysiological and neurobehavioral measurements known to be sensitive to alcohol exposure. The present study determined the age-related effects of acute alcohol on behavioral and eventrelated potential (ERP) responses to acoustic startle (AS) and prepulse inhibition (PPI).

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“…Several electrophysiological indices that might serve as endophenotypes for risk or protective genetic factors differ between the HAP1 and LAP1 lines (Slawecki et al 2003). However, the electrophysiological findings in HAP1/LAP1 do not in general correspond with electrophysiological variables previously reported to differentiate P versus NP rats or HAD versus LAD selected rat lines (Slawecki et al 1999(Slawecki et al , 2000a. Ultimately, these selected mouse lines could also be used for gene mapping purposes (see next section).…”

Section: Selected Linesmentioning

confidence: 93%