Neuropolybin: A new antiseizure peptide obtained from wasp venom

Silva, Juliana de Castro e; Couto, Lucianna Lopes do; Amaral, Henrique de Oliveira; Gomes, Flávia Maria Medeiros; Campos, Gabriel Avohay Alves; Silva, Luciano; Mortari, Márcia Renata

doi:10.1016/j.bcp.2020.114119

Cited by 14 publications

(10 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cockroach has the ability to walk, run, or fly if properly stimulated, but it does not try to escape as it is slowly eaten alive by the developing wasp larva [90]. Insects have a myriad of interesting neurotoxins [91], some of which are being researched to be used as anti-seizure Ruwanpathirana and Priyankara Tropical Medicine and Health (2022) 50:82 medication [92] and against neurodegenerative diseases [93].…”

Section: Nervous System Effectsmentioning

confidence: 99%

Clinical manifestations of wasp stings: a case report and a review of literature

Ruwanpathirana

Priyankara²

2022

Trop Med Health

View full text Add to dashboard Cite

Background Wasp stinging, a neglected tropical entity can have a myriad of local and systemic effects. We present a case of multi-organ injury following multiple wasp stings and a review of literature on the systemic manifestations of wasp stings. Case presentation A 48-year-old Sri Lankan male who suffered multiple wasp stings, developed an anaphylactic shock with respiratory failure, which was treated with adrenaline and mechanical ventilation. Within the next 2 days the patient developed acute fulminant hepatitis, stage III acute kidney injury, rhabdomyolysis, haemolysis and thrombocytopenia. The patient was treated in the intensive care unit with ionopressors and continuous renal replacement therapy (CRRT). Haemoadsorbant therapy was used in adjunct with CRRT. There was a gradual recovery of the organ functions over the 1st week. However, the patient succumbed to fungal sepsis on the 16th day despite treatment. We conducted a literature review to identify the various clinical manifestations of wasp stinging. Wasp venom contains enzymes, amines, peptides and other compounds. These proteins can cause type 1 hypersensitive reactions ranging from local skin irritation to anaphylactic shock. Furthermore, the toxins can cause direct organ injury or delayed hypersensitivity reactions. The commonly affected organs are the kidneys, liver, and muscles. The effect on the haematological system manifests as coagulopathy and/or cytopenia. The heart, nervous system, lungs, intestines and skin can be affected rarely. Treatment is mainly supportive. Conclusion In conclusion, wasp envenomation can result in multi-organ injury and attention should be paid in doing further research and establishing evidence-based treatment practices.

show abstract

Section: Nervous System Effectsmentioning

confidence: 99%

Clinical manifestations of wasp stings: a case report and a review of literature

Ruwanpathirana

Priyankara²

2022

Trop Med Health

View full text Add to dashboard Cite

show abstract

“…Neuropolybin, isolated from the venom of the wasp Polybia paulista, is a novel example of the potential antiepileptic properties of animal peptides (de Castro e Silva et al, 2020). Similarly, another peptide called Chartergellus-CP1, extracted from the venom of the social wasp Chartergellus communis, showed a significant antiseizure potential against chemically induced seizures in mice (Lopes et al, 2021).…”

Section: Peptides Derived From Animal Venomsmentioning

confidence: 99%

“…The exact mechanism of action of some peptides is not elucidated yet, but even so they demonstrate evidence of antiepileptic activity—some examples are the peptides Neuropolybin and Chartergellus‐CP1. Neuropolybin, isolated from the venom of the wasp Polybia paulista , is a novel example of the potential antiepileptic properties of animal peptides (de Castro e Silva et al, 2020). Similarly, another peptide called Chartergellus‐CP1, extracted from the venom of the social wasp Chartergellus communis , showed a significant antiseizure potential against chemically induced seizures in mice (Lopes et al, 2021).…”

Section: Innovative Therapeutic Options For Epilepsymentioning

confidence: 99%

Innovative treatments for epilepsy: Venom peptides, cannabinoids, and neurostimulation

Lima

Loyola

Bicca

et al. 2022

J of Neuroscience Research

View full text Add to dashboard Cite

Antiepileptic drugs have been successfully treating epilepsy and providing individuals sustained seizure freedom. However, about 30% of the patients with epilepsy present drug resistance, which means they are not responsive to the pharmacological treatment. Considering this, it becomes extremely relevant to pursue alternative therapeutic approaches, in order to provide appropriate treatment for those patients and also improve their quality of life. In the light of that, this review aims to discuss some innovative options for the treatment of epilepsy, which are currently under investigation, addressing strategies that go from therapeutic compounds to clinical procedures. For instance, peptides derived from animal venoms, such as wasps, spiders, and scorpions, demonstrate to be promising antiepileptic molecules, acting on a variety of targets. Other options are cannabinoids and compounds that modulate the endocannabinoid system, since it is now known that this network is involved in the pathophysiology of epilepsy. Furthermore, neurostimulation is another strategy, being an alternative clinical procedure for drug‐resistant patients who are not eligible for palliative surgeries.

show abstract

“…Still, several venomous or poisonous species of snakes, lizards, and leeches have already been used to produce toxin-based drugs for clinical applications directed against disease-induced pain (e.g., from osteoarthritis and multiple sclerosis), as anticoagulants for specific coronary interventions and also for hypertension or specific types of diabetes (see Bordon et al, 2020 for a review). Additionally, studies on wasp venoms are revealing promising alternatives for traditional antibiotics and even as antiviral and anti-seizure therapeutics (Vila-Farrés et al, 2012;Sample et al, 2013;Castro e Silva et al, 2020). In turn, pushed by the recent premises of the "Blue Growth" revolution, the last decade witnessed a growing interest in marine bioproducts, toxins included.…”

Section: Introductionmentioning

confidence: 99%

Cephalotoxins: A Hotspot for Marine Bioprospecting?

Gonçalves

Costa

2021

Front. Mar. Sci.

View full text Add to dashboard Cite

Molluscs provided one of the pioneering approved pharmaceuticals from the seas: the painkiller ziconotide, developed from an ω-conotoxin isolated from cone snails. As marine biotechnologists are turning towards the immense range of novel bioproducts from marine invertebrates, little attention has been given to cephalotoxins, a group of obscure proteinaceous toxins produced by the salivary glands of coleoids, i.e., octopuses, squids and cuttlefishes. These toxins, for which there is empirical evidence for acting as immobilisers at least against crustaceans, are proteinaceous substances among the many that comprise the venomous mixtures secreted by these animals. Despite the ecological and economical importance of cephalopods, little is known about cephalotoxins, beginning with the actual span of taxa that secrete them. Indeed, cephalopods are long suspected for producing specific toxins as part of their predation and defence mechanisms, making them a promising group of marine animals for the bioprospecting of novel compounds. Despite scant or absent toxicological or otherwise experimental evidence for their bioreactivity, advances in “omics” methods have shed some light in the molecular structure of cephalotoxins. There are reports of cephalotoxins being complex glycoproteins that take part in a myriad of novel compounds being produced by the salivary glands. Still, there is no consensus of cephalotoxins being a conserved form of proteins. As Blue Biotechnology and marine bioprospecting for novel bioreactives are gaining momentum, the present review will provide the state-of-the-art on cephalotoxins, highlighting old and new research and existing gaps in the current knowledge.

show abstract

Neuropolybin: A new antiseizure peptide obtained from wasp venom

Cited by 14 publications

References 31 publications

Clinical manifestations of wasp stings: a case report and a review of literature

Clinical manifestations of wasp stings: a case report and a review of literature

Innovative treatments for epilepsy: Venom peptides, cannabinoids, and neurostimulation

Cephalotoxins: A Hotspot for Marine Bioprospecting?

Contact Info

Product

Resources

About