Neuroprotective and acetylcholinesterase inhibitory activities of alkaloids from Solanum lyratum Thunb.: An in vitro and in silico analyses

Chang, Ye; Bai, Ming; Zhang, Xin; Shen, Shuai; Hou, Jiao-Yang; Yao, Guo‐Dong; Huang, Xiao‐Xiao; Song, Shao‐Jiang

doi:10.1016/j.phytochem.2023.113623

Cited by 11 publications

(3 citation statements)

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“…The consumption S. melongena increased the level of total protein with the best significance in group Sm400 and Sm10%. The powder and extract of S. melongena contain some bioactive compounds including alkaloids, steroids, vitamins C, zinc, selenium, chlorogenic acid and caffeic acid which reduce oxidative stress and cognitive impairments in rats [47]. These bioactive compounds are reported to act through several mechanisms including expression of genes responsible for the secretion of compounds with benefit effect, reduction of oxidative stress incidence by neutralizing free radicals through oxidoreduction reactions [48].…”

Section: Discussionmentioning

confidence: 99%

Effect of Nutrients and Phytochemical Compounds of Solanum melongena (Eggplants) on Cognitive Protection in Rats

Tsafack,

Tchinda,

Kemtsop

et al. 2024

JDMP

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Many factors among which life style and oxidative stress are implicated in the incidence of neurodegenerative diseases. One of the ways to prevent neurodegeneration is to supply the body with antioxidant molecules derived from food. The aim of this study is to evaluate the nutritional value and neuroprotective activities of eggplants on cognitive impaired rat model. Powder was made with the white and purple Solanum melongena and the nutritional value of each was determined. Total phenolic and flavonoid content, antioxidant activity by DPPH scavenging and reducing iron tests, were determined from aqueous, ethanolic and hydroethanolic fruit extracts. The powder and the most active extract of Solanum melongena were used to determine neuroprotective activity in rats. Male wistar rats were divided into 7 groups of 6 each. Morris water maze and radial maze tests were performed at the end of the experiment to assess behaviour in rats. After 28 days, the rats were sacrificed and biochemical investigations such as protein content, reduced glutathione, catalase activity, malondiadehyde and acetylcholinesterase activity were evaluated in brain homogenates. The purple Solamun melongena showed the highest ash (6.06%), calcium (10.50 mg/100 g of desiccated foods), phosphorus (25.75 mg/100 g of desiccated foods), potassium (218.00 mg/100 g of desiccated foods) and zinc (0.18 mg/100 g of desiccated foods) content. On the other hand, white Solanum melongena showed the highest fiber (3.61%) and iron (0.36 mg/100 g of desiccated foods) content. The greatest phenolic content (69.90 mg GAE /g) and flavonoid content (31.54 mg CATE / g) was observed with the purple Solanum melongena. It also presented the best scavenging DPPH activity (EC 50 = 41.91 μg/ml). The group Sm400 showed the best memory learning activity with radial maze tests (0.66 n/min), a significant decrease of malondialdehyde (15.26 µmole/g), acetylcholinesterase activity (0.13 nmol/min/mg protein) and an increase of protein content (43.71µmole/g) (P<0.05). The group Sm10% showed the best memory capacity radial maze tests (0.73 n/min), the lowest malondialdehyde level and acetylcholinesterase activity (12.45 µmole/g and 0.11nmol/min/mg protein respectively) (P<0.05). Purple Solanum melongena could be used to protect neuron functions.

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Section: Discussionmentioning

confidence: 99%

Effect of Nutrients and Phytochemical Compounds of Solanum melongena (Eggplants) on Cognitive Protection in Rats

Tsafack,

Tchinda,

Kemtsop

et al. 2024

JDMP

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“…The AChE inhibitory activities of all isolates (1a/1b-7) were obtained via an Ellman assay as previously described. [34][35][36] 2.10 Molecular docking…”

Section: Neuroprotective Activity Assaymentioning

confidence: 99%

Stereochemical investigations of bioactive dihydrobenzofuran-type lignanamides from Solanum lyratum: chiral resolution, in vitro and in silico profiling

et al. 2023

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“…The elevated AChE activity affects Ach release due to its rapid hydrolysis to acetic acid and choline. This terminates the impulse transmission at the cholinergic synapses in numerous cholinergic pathways in the central and peripheral nervous systems [2,3]. It is assumed that at high ACh concentrations, each AChE active site hydrolyses 10,000 molecules of substrate per second [1,4].…”

Section: Introductionmentioning

confidence: 99%

Significance of Astragaloside IV from the Roots of Astragalus mongholicus as an Acetylcholinesterase Inhibitor—From the Computational and Biomimetic Analyses to the In Vitro and In Vivo Studies of Safety

Stępnik

Kukuła-Koch

Płaziński

et al. 2023

IJMS

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The main aim of the study was to assess the acetylcholinesterase-inhibitory potential of triterpenoid saponins (astragalosides) found in the roots of Astragalus mongholicus. For this purpose, the TLC bioautography method was applied and then the IC50 values were calculated for astragalosides II, III and IV (5.9 μM; 4.2 μM, and 4.0 μM, respectively). Moreover, molecular dynamics simulations were carried outto assess the affinity of the tested compounds for POPC and POPG-containing lipid bilayers, which in this case are the models of the blood-brain barrier (BBB). All determined free energy profiles confirmed that astragalosides exhibit great affinity for the lipid bilayer. A good correlation was obtained when comparing the logarithm of n-octanol/water partition coefficient (logPow) lipophilicity descriptor values with the smallest values of free energy of the determined 1D profiles. The affinity for the lipid bilayers changes in the same order as the corresponding logPow values, i.e.,: I > II > III~IV. All compounds exhibit a high and also relatively similar magnitude of binding energies, varying from ca. −55 to −51 kJ/mol. Apositive correlation between the experimentally-determined IC50 values and the theoretically-predicted binding energies expressed by the correlation coefficient value equal 0.956 was observed.

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Neuroprotective and acetylcholinesterase inhibitory activities of alkaloids from Solanum lyratum Thunb.: An in vitro and in silico analyses

Cited by 11 publications

References 50 publications

Effect of Nutrients and Phytochemical Compounds of <i>Solanum melongena</i> (Eggplants) on Cognitive Protection in Rats

Effect of Nutrients and Phytochemical Compounds of <i>Solanum melongena</i> (Eggplants) on Cognitive Protection in Rats

Stereochemical investigations of bioactive dihydrobenzofuran-type lignanamides from Solanum lyratum: chiral resolution, in vitro and in silico profiling

Significance of Astragaloside IV from the Roots of Astragalus mongholicus as an Acetylcholinesterase Inhibitor—From the Computational and Biomimetic Analyses to the In Vitro and In Vivo Studies of Safety

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Neuroprotective and acetylcholinesterase inhibitory activities of alkaloids from Solanum lyratum Thunb.: An in vitro and in silico analyses

Cited by 11 publications

References 50 publications

Effect of Nutrients and Phytochemical Compounds of &lt;i&gt;Solanum melongena&lt;/i&gt; (Eggplants) on Cognitive Protection in Rats

Effect of Nutrients and Phytochemical Compounds of &lt;i&gt;Solanum melongena&lt;/i&gt; (Eggplants) on Cognitive Protection in Rats

Stereochemical investigations of bioactive dihydrobenzofuran-type lignanamides from Solanum lyratum: chiral resolution, in vitro and in silico profiling

Significance of Astragaloside IV from the Roots of Astragalus mongholicus as an Acetylcholinesterase Inhibitor—From the Computational and Biomimetic Analyses to the In Vitro and In Vivo Studies of Safety

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Effect of Nutrients and Phytochemical Compounds of <i>Solanum melongena</i> (Eggplants) on Cognitive Protection in Rats

Effect of Nutrients and Phytochemical Compounds of <i>Solanum melongena</i> (Eggplants) on Cognitive Protection in Rats