Neuroprotective effect of ace inhibitors in glutamate-induced neurotoxicity: rat neuron culture study

Sengul, Goksin; Coşkun, Şahin; Çakır, Mürteza; Çoban, Mustafa Kemal; Saruhan, Fatih; Hacımüftüoğlu, Ahmet

doi:10.5137/1019-5149.jtn.4313-11.0

Cited by 10 publications

(9 citation statements)

References 22 publications

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“…This effect may be due to the increase in glutaminase enzyme activity in the intestine, which may occur in the control group supplemented with L-glutamine [ 51 ]. As the control group has no lack of L-glutamine, glutaminase could lead to a large production of L-glutamate, which is related to neurotoxicity [ 52 ]. The affected neurons could be unregulating proliferative and motor processes in the intestine.…”

Section: Discussionmentioning

confidence: 99%

Supplementation with L-Glutamine and L-Alanyl-L-Glutamine Changes Biochemical Parameters and Jejunum Morphophysiology in Type 1 Diabetic Wistar Rats

et al. 2015

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We evaluated the effects of the supplementation with L-glutamine and glutamine dipeptide (GDP) on biochemical and morphophysiological parameters in streptozotocin-diabetic rats. For this purpose, thirty animals were distributed into six groups treated orally (gavage) during thirty days: non diabetic rats (Control) + saline, diabetic + saline; Control + L-glutamine (248 mg/kg), Diabetic + L-glutamine (248 mg/kg), Control + GDP (400 mg/kg), Diabetic + GDP (400 mg/kg). Diabetes was induced by an intravenous injection of streptozotocin (60 mg/kg) and confirmed by fasting glucose ≥ 200 mg/dL. Physiological parameters, i.e., body mass, food intake, blood glucose, water intake, urine and faeces were evaluated during supplementation. After the period of supplementation, the animals were euthanized. The blood was collected for biochemical assays (fructosamine, transaminases, lipid profile, total protein, urea, ammonia). Moreover, the jejunum was excised and stored for morphophysiological assays (intestinal enzyme activity, intestinal wall morphology, crypt proliferative index, number of serotoninergic cells from the mucosa, and vipergic neurons from the submucosal tunica). The physiological parameters, protein metabolism and intestinal enzyme activity did not change with the supplementation with L-glutamine or GDP. In diabetic animals, transaminases and fructosamine improved with L-glutamine and GDP supplementations, while the lipid profile improved with L-glutamine. Furthermore, both forms of supplementation promoted changes in jejunal tunicas and wall morphometry of control and diabetic groups, but only L-glutamine promoted maintenance of serotoninergic cells and vipergic neurons populations. On the other hand, control animals showed changes that may indicate negative effects of L-glutamine. Thus, the supplementation with L-glutamine was more efficient for maintaining intestinal morphophysiology and the supplementation with GDP was more efficient to the organism as a whole. Thus, we can conclude that local differences in absorption and metabolism could explain the differences between the supplementation with L-glutamine or GDP.

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Section: Discussionmentioning

confidence: 99%

Supplementation with L-Glutamine and L-Alanyl-L-Glutamine Changes Biochemical Parameters and Jejunum Morphophysiology in Type 1 Diabetic Wistar Rats

et al. 2015

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“…Other facets include Ang II-mediated enhancement of BBB permeability [85][86][87]; stimulated increases in tumour necrosis factor a [88] and transforming growth factor b-mediated [89,90] CNS inflammation; and potential enhancement of glutamate-induced neurotoxicity [91].…”

Section: Considerations For Inhibition Of Ang II In Relation To Dementiamentioning

confidence: 99%

Current status of renin–aldosterone angiotensin system-targeting anti-hypertensive drugs as therapeutic options for Alzheimer's disease

Ashby¹,

Kehoe²

2013

Expert Opinion on Investigational Drugs

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“…The excessive concentrations of calcium ions (Ca 2+ ) in the intracell results in mitochondrial dysfunction followed by the release of free radicals and the stimulation of the MAPK protein p38 (mitogen-activated protein kinase p38) which activates transcription factors. This results in damage and neuronal cell apoptosis [19,20]. Park et al [21] reported, MSG at a dose of 4 mg g -1 BW in adult rats gave rise to neurodegeneration in the form of fewer neurons than controls.…”

Section: Results and Discussion Effects Of Msg On Serum Levels Of Lhmentioning

confidence: 99%

Effects of Monosodium Glutamate Oral Administration on LH and Testosterone Levels in Serum of Adult Male Rats (Rattus norvegicus)

Annisa

Djati

Rahayu

2019

JELS

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This study aims to determine the effect of monosodium glutamate on LH and testosterone levels in serum of adult male rats (Rattus norvegicus). A total of 12 male Wistar-strained rats divided into three groups with 4 rats per group. Control group was given distilled water, while M1 was given MSG at a dose of 4mg.gBW -1 for 15 days and M2 was given MSG at a dose of 4 mg.gBW -1 for 45 days. All substances were given orally. At the end of the study, rats were sacrificed with a dislocation to draw blood from the heart. Then, the blood was incubated at room temperature to obtain serum. Serum was used to analyze LH and testosterone levels using the ELISA kit. Data were analyzed using one way ANOVA (p ≤ 0.05) with SPPS 16.0 for windows. The results showed that serum LH levels after MSG treatment for 45 days was significantly decreased compare with the control. The serum testosterone levels M2 was significantly different from the control group (p ≤ 0.01). This study predicts that monosodium glutamate have a direct and indirect effect on male reproductive organs.

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Neuroprotective effect of ace inhibitors in glutamate-induced neurotoxicity: rat neuron culture study

Cited by 10 publications

References 22 publications

Supplementation with L-Glutamine and L-Alanyl-L-Glutamine Changes Biochemical Parameters and Jejunum Morphophysiology in Type 1 Diabetic Wistar Rats

Supplementation with L-Glutamine and L-Alanyl-L-Glutamine Changes Biochemical Parameters and Jejunum Morphophysiology in Type 1 Diabetic Wistar Rats

Current status of renin–aldosterone angiotensin system-targeting anti-hypertensive drugs as therapeutic options for Alzheimer's disease

Effects of Monosodium Glutamate Oral Administration on LH and Testosterone Levels in Serum of Adult Male Rats (Rattus norvegicus)

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