Neuroprotective Effect of CeO2@PAA-LXW7 Against H2O2-Induced Cytotoxicity in NGF-Differentiated PC12 Cells

Jia, Jingjing; Zhang, Ting; Chi, Jieshan; Liu, Xiaoma; Sun, Jingjing; Xie, Qizhi; Peng, Sai; Li, Chang‐Yan; Li, Yang

doi:10.1007/s11064-018-2559-y

Cited by 9 publications

(3 citation statements)

References 73 publications

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“…Lattice fringes were observed on the surface of SiO 2 @MnO x -CeO 2 NPs, MnO x -CeO 2 NPs and CeO 2 NPs, the lattice spacing in these nanoparticles was 0.310 nm, 0.310 nm and 0.313 nm, respectively, which represent the standard lattice spacing of the (111) crystal plane of the cubic CeO 2 . 23 The smaller lattice spacing in SiO 2 @MnO x -CeO 2 NP and MnO x -CeO 2 NP may be related to the decreased crystallinity resulted from Mn doping. In addition, the intensity of diffraction rings in the SAED (selected area electron diffraction) pattern of MnO x -CeO 2 NPs was much lower than that of SiO 2 @MnO x -CeO 2 NP, the (111), (220) and (311) crystal planes corresponded to the cubic CeO 2 .…”

Section: Resultsmentioning

confidence: 98%

Mesoporous Hollow Manganese Doped Ceria Nanoparticle for Effectively Prevention of Hepatic Ischemia Reperfusion Injury

Si¹,

Lei²,

Yang³

et al. 2023

IJN

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Introduction Hepatic ischemia-reperfusion injury (HIRI) is the main reason for liver dysfunction or failure after liver resection and liver transplantation. As excess accumulation of reactive oxygen species (ROS) is the leading factor, ceria nanoparticle, a cyclic reversible antioxidant, is an excellent candidate for HIRI. Methods Manganese doped mesoporous hollow ceria nanoparticles (MnO x -CeO 2 NPs) were prepared, and the physicochemical characteristics, such as particle size, morphology, microstructure, etc. were elucidated. The in vivo safety and liver targeting effect were examined after i.v. injection. The anti-HIRI was determined by a mouse HIRI model. Results MnO x -CeO 2 NPs with 0.40% Mn doped exhibited the strongest ROS-scavenging capability, which may due to the increased specific surface area and surface oxygen concentration. The nanoparticles accumulated in the liver after i.v. injection and exhibited good biocompatibility. In the HIRI mice model, MnO x -CeO 2 NPs significantly reduced the serum ALT and AST level, decreased the MDA level and increased the SOD level in the liver, prevent pathological damages in the liver. Conclusion MnO x -CeO 2 NPs were successfully prepared and it could significantly inhibit the HIRI after i.v. injection.

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Section: Resultsmentioning

confidence: 98%

Mesoporous Hollow Manganese Doped Ceria Nanoparticle for Effectively Prevention of Hepatic Ischemia Reperfusion Injury

Si¹,

Lei²,

Yang³

et al. 2023

IJN

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“…Although several studies have reported that CeO 2 protected cells against oxidative damage as an antioxidant, , our research first explored the potential mechanisms of CeO 2 -mediated bioactivity by considering the effect of surface structures. Specifically, CeO 2 nanozymes in different shapes exhibited a distinct ability to modulate the redox homeostasis in NPCs.…”

Section: Resultsmentioning

confidence: 99%

Facet-Dependent Activity of CeO₂ Nanozymes Regulate the Fate of Human Neural Progenitor Cell via Redox Homeostasis

Wang

Tan

Zhang

et al. 2022

ACS Appl. Mater. Interfaces

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Neural progenitor cells (NPCs) therapy, a promising therapeutic strategy for neurodegenerative diseases, has a huge challenge to ensure high survival rate and neuronal differentiation rate. Cerium oxide (CeO2) nanoparticles exhibit multienzyme mimetic activities and have shown the capability of regulating reactive oxygen species (ROS), which is a pivotal mediator for intracellular redox homeostasis in NPCs, regulating biological processes including differentiation, proliferation, and apoptosis. In the present study, the role of facet-dependent CeO2-mediated redox homeostasis in regulating self-renewal and differentiation of NPCs is reported for the first time. The cube-, rod-, and octahedron-shaped CeO2 nanozymes with different facets are prepared. Among the mentioned nanozymes, the cube enclosed by the (100) facet exhibits the highest CAT-like activity, causing it to provide superior protection to NPCs from oxidative stress induced by H2O2; meanwhile, the octahedron enclosed by the (111) facet with the lowest CAT-like activity induces the most ROS production in ReNcell CX cells, which promotes neuronal differentiation by activated AKT/GSK-3β/β-catenin pathways. A further mechanistic study indicated that the electron density of the surface Ce atoms changed continuously with different crystal facets, which led to their different CAT-like activity and modulation of redox homeostasis in NPCs. Altogether, the different surface chemistry and atomic architecture of active sites on CeO2 exert modulation of redox homeostasis and the fate of NPCs.

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“…Instead, it improved neuronal differentiation by extending neurite length (Ciofani et al., 2013). Nanoceria modified with the functional group of polyacrylic acid alleviated H 2 O 2 -induced oxidative stress in PC12 cells by regulating cleaved caspase-3 and mitochondrial cytochrome c in the apoptosis-related pathways (Jia et al., 2018). Ceria/polyoxometalate hybrid can degrade amyloid-β aggregates, reduce intracellular ROS, and deactivate microglial cells, which leads to decreased neurotoxicity (Guan et al., 2016).…”

Section: Introductionmentioning

confidence: 99%

Asymmetrical 3D Nanoceria Channel for Severe Neurological Defect Regeneration

et al. 2019

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SummaryInflammation and oxidative stress are major problems in peripheral nerve injury. Nanoceria can manipulate antioxidant factor expression, stimulate angiogenesis, and assist in axonal regeneration. We fabricate collagen/nanoceria/polycaprolactone (COL/NC/PCL) conduit by asymmetrical three-dimensional manufacture and find that this scaffold successfully improves Schwann cell proliferation, adhesion, and neural expression. In a 15-mm rat sciatic nerve defect model, we further confirm that the COL/NC/PCL conduit markedly alleviates inflammation and oxidative stress, improves microvessel growth, and contributes to functional, electrophysiological, and morphological nerve restoration in the long term. Our findings provide compelling evidence for future research in antioxidant nerve conduit for severe neurological defects.

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Neuroprotective Effect of CeO2@PAA-LXW7 Against H2O2-Induced Cytotoxicity in NGF-Differentiated PC12 Cells

Cited by 9 publications

References 73 publications

Mesoporous Hollow Manganese Doped Ceria Nanoparticle for Effectively Prevention of Hepatic Ischemia Reperfusion Injury

Mesoporous Hollow Manganese Doped Ceria Nanoparticle for Effectively Prevention of Hepatic Ischemia Reperfusion Injury

Facet-Dependent Activity of CeO₂ Nanozymes Regulate the Fate of Human Neural Progenitor Cell via Redox Homeostasis

Asymmetrical 3D Nanoceria Channel for Severe Neurological Defect Regeneration

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Neuroprotective Effect of CeO2@PAA-LXW7 Against H2O2-Induced Cytotoxicity in NGF-Differentiated PC12 Cells

Cited by 9 publications

References 73 publications

Mesoporous Hollow Manganese Doped Ceria Nanoparticle for Effectively Prevention of Hepatic Ischemia Reperfusion Injury

Mesoporous Hollow Manganese Doped Ceria Nanoparticle for Effectively Prevention of Hepatic Ischemia Reperfusion Injury

Facet-Dependent Activity of CeO2 Nanozymes Regulate the Fate of Human Neural Progenitor Cell via Redox Homeostasis

Asymmetrical 3D Nanoceria Channel for Severe Neurological Defect Regeneration

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Product

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Facet-Dependent Activity of CeO₂ Nanozymes Regulate the Fate of Human Neural Progenitor Cell via Redox Homeostasis