Neuroprotective effect of treatment with galantamine and choline alphoscerate on brain microanatomy in spontaneously hypertensive rats

Spontaneously hypertensive rat as a model of vascular brain disorder: Microanatomy, neurochemistry and behavior

“…In summary, similarly as reported in VaD, an impaired cholinergic neurotransmission characterizes both SHR and SHR-SP. The possibility that cholinergic neurotransmission mechanisms contribute to central nervous system plasticity or may improve brain circulation in this animal model is suggested by our recent studies [132,[137][138][139]. In these experiments, we have observed that treatment of SHR with the AChE inhibitor galantamine or with the cholinergic precursor choline alphoscerate (alpha-glycerylphosphoryl-choline), alone or in association, although not affecting blood pressure levels, exerts a neuroprotective effect countering typical hypertension-dependent microanatomical changes in SHR [137].…”

The ASCOMALVA trial: Association between the cholinesterase inhibitor donepezil and the cholinergic precursor choline alphoscerate in Alzheimer's disease with cerebrovascular injury: Interim results

“…In fact, the precursor could make available more substrate for acetylcholine synthesis, the degradation of which is slowed down by the ChE-I. In line with this hypothesis are preclinical studies showing that association of the cholinergic precursor choline alphoscerate (alpha-glyceryl-phosphorylcholine) with a ChE-I significantly enhances cholinergic neurotransmission [12], and exerts a more remarkable neuroprotective effect than single compounds alone [13].…”

“…The present clinical study was designed to assess if the cholinergic precursor/ChE-I association documented to be effective in preclinical studies [12,13] may represent a therapeutic option to prolong/increase beneficial effects of cholinergic therapies in AD patients with concomitant ischemic cerebrovascular disease.…”

Acetylcholinergic Therapy in the Recovery Period of Ischemic Stroke

“…Глицерофосфат активизирует синтез фосфолипидов мембраны нейронов и тем самым повышает пластичность мембран и функцию рецепторного аппарата. На модели крыс со спонтанной артериальной гипертензией показана способность холина альфосцерата замедлять развитие астроглиоза и препятствовать разрушению фосфорилированных нейрофиламентов, предупреждая таким образом гибель нейронов [23,24]. Кроме того, при экспериментальном ишемическом инсульте холина альфосцерат уменьшал зону инфаркта [25].…”