Neuroprotective effects of mesenchymal stem cells through autophagy modulation in a parkinsonian model

Dopaminergic differentiation of stem cells from human deciduous teeth and their therapeutic benefits for Parkinsonian rats

“…It was previously reported that naïve, neurotrophic factorsecreting, or neurally induced MSCs have therapeutic effects when transplanted into 6-OHDA-or MPTP-induced Parkinsonian animals (Biju et al, 2013;Capitelli et al, 2014;Dezawa et al, 2004;Glavaski-Joksimovic et al, 2010;McCoy et al, 2008;Park et al, 2014;Sadan et al, 2009;Wang et al, 2013;Weiss et al, 2006;Yan et al, 2013). A beneficial effect of the striatal transplantation of both SHEDs and DAergic neuronlike SHEDs was also previously reported (Wang et al, 2010).…”

Intracarotid Infusion of Mesenchymal Stem Cells in an Animal Model of Parkinson's Disease, Focusing on Cell Distribution and Neuroprotective and Behavioral Effects

“…More recently, stem cells have been proposed as a promising tool to achieve neurorestoration in the PD brain. Numerous studies have been conducted in PD animal models, with different stem cell types, including embryonic [5][6][7] or adult neural stem cells [8], dopaminergic cells differentiated from fibroblast-derived inducible pluripotent stem (iPS) cells [9][10][11] and bone marrow-and adiposederived mesenchymal stem cells (MSCs) [12][13][14][15][16][17][18][19][20][21][22].…”

Rapamycin protects dopaminergic neurons against rotenone-induced cell death in primary mesencephalic cell culture

“…For instance, Dehay et al [7] reported that the number of undegraded autophagosomes increased and the number of autophagolysosomes decreased in post-mortem PD brain samples. Park et al [25] showed that MPP + inhibited autophagosome formation and increased a-synuclein expression in mice. Parganlija et al [24] found that SH-SY5Y cells with PINK1 knockdown showed down-regulation of key autophagic genes including Beclin, LC3 and LAMP-2.…”