2018
DOI: 10.1002/jnr.24326
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Neuroprotective effects of SMTP‐44D in mice stroke model in relation to neurovascular unit and trophic coupling

Abstract: Stachybotrys microspora triprenyl phenol (SMTP)‐44D has both anti‐oxidative and anti‐inflammatory activities, but its efficacy has not been proved in relation to the pathological changes of neurovascular unit (NVU) and neurovascular trophic coupling (NVTC) in ischemic stroke. Here, the present study was designed to assess the efficacies of SMTP‐44D, moreover, compared with the standard neuroprotective reagent edaravone in ischemic brains. ICR mice were subjected to transient middle cerebral artery occlusion (t… Show more

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Cited by 19 publications
(13 citation statements)
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“…This is also consistent with some other animal experiments [ 45 , 46 ]. Meanwhile, at the downstream of the BDNF/TrkB signaling pathway, the changes in the TrkB level reflected those of BDNF in both our study and others [ 47 , 48 ]. EA/TNS was found to reverse these changes in our study, suggesting that it restores cognitive function by enhancing the BDNF/TrkB pathway to contribute to neuroprotection.…”
Section: Discussionsupporting
confidence: 78%
“…This is also consistent with some other animal experiments [ 45 , 46 ]. Meanwhile, at the downstream of the BDNF/TrkB signaling pathway, the changes in the TrkB level reflected those of BDNF in both our study and others [ 47 , 48 ]. EA/TNS was found to reverse these changes in our study, suggesting that it restores cognitive function by enhancing the BDNF/TrkB pathway to contribute to neuroprotection.…”
Section: Discussionsupporting
confidence: 78%
“…Indeed, several experiments with transient focal ischemia models demonstrated reduced levels of the following in SMTP-treated animals: (i) reactive oxygen species (ROS) [ 27 , 133 ]; (ii) markers of oxidative damage [ 24 ]; (iii) matrix metalloproteinase-9 (MMP-9) and blood–brain barrier (BBB) disruption [ 23 , 27 ]; (iv) inflammatory cytokines and neuroinflammation-related proteins [ 159 ]; and (v) hemorrhagic transformation [ 23 , 24 ]. Moreover, SMTP-44D, a non-thrombolytic but sEH-inhibitory congener, was shown to reduce oxidative damage markers and protect neurovascular units and trophic coupling from impairment in a mouse model of transient focal ischemia [ 30 ].…”
Section: Pharmacological Activity Of Smtpmentioning
confidence: 99%
“…In process ( ii ), inhibition of C-EH-catalyzed hydrolysis of anti-inflammatory epoxy fatty acids such as epoxyeicosatrienoic acid (EET) may play a role; inhibition of N-phos may play an additional role (not shown). In process ( iii ), radical-scavenging activity inherent in the SMTP structure plays a role in the suppression of oxidative modifications of lipids, proteins, nucleic acids, and sugars [ 27 , 30 , 133 , 158 , 159 ], which are implicated in cytotoxicity, tissue damage, and inflammation. Anti-inflammatory/antioxidative effects contribute to the suppression of neuronal damage and hemorrhagic transformation ( iv ).…”
Section: Figurementioning
confidence: 99%
See 1 more Smart Citation
“…[19] Among the SMTPs, SMTP-44D was reported to have effective antioxidant and anti-inflammatory activities. [20][21][22] However, it remains unknown whether SMTP-44D has therapeutic effects in DN or if its antioxidant and anti-inflammatory activities could improve allodynia, hyperalgesia, decrease in blood flow, delay of conduction velocity, and neurological degeneration in…”
Section: Introductionmentioning
confidence: 99%