Neuropsychological deficits and real-world dysfunction in cerebral revascularization candidates

Abstract

An assessment strategy using multiple levels of observation permitted description of problems in everyday living experienced by cerebral revascularization candidates. We contrasted the neuropsychological deficits and real-world dysfunction displayed by candidates for cerebral revascularization with that manifested by patients with severe spinal complaints. Correlations between selected neuropsychological scores and life quality measures were modest. Prediction of real-world performance in individuals likely will require multivariate combinations of measures. Relationships between life quality measures and neuropsychological scores may differ for patients with known or suspected neurological disease and patients with disorders which do not threaten cognitive functioning.

Effects of Vigabatrin on Cognitive Function and Mood When Used as Add‐on Therapy in Patients with Intractable Epilepsy

“…An important issue often neglected in studies such as the present study is the clinical relevance of statistically significant changes in cognitive function. Studies have demonstrated a link between objective assessments of cognitive functioning and everyday performance Newnan et al, 1978;McSweeny et al, 1985;Baird et al, 1987), but little or no research has investigated change in objective cognitive test performance in relation to changes in daily functioning. It is hypothesized that changes in objective psychological testing need to be of relatively large magnitude before they become important at the clinical level.…”

The Impact of Behavioral Symptoms on Activities of Daily Living in Patients With Dementia

“…In order to be included in the study, subjects had to meet the following criteria: 1) the patient had to meet diagnostic criteria for dementia; (2) the patient had to be compliant with administration of a full neuropsychological evaluation; and (3) a reliable informant with whom the patient had frequent contact had to be present at the time of the appointment. Their mean Mattis Dementia Rating Scale (DRS) score was ‫5.21ע5.311‬ (range: 87-132), and their mean Mini-Mental State Exam (MMSE) score was ‫0.4ע0.22‬ (range: [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. Patients' diagnoses included probable Alzheimer's disease (AD; n‫,)02ס‬ vascular dementia (n‫,)3ס‬ Lewy body disease (n‫,)2ס‬ alcohol dementia (n‫,)1ס‬ dementia due to multiple etiologies (n‫,)2ס‬ and dementia of unknown etiology (n‫.…”

Assessing Success after Cerebral Revascularization for Ischemia

“…Baird and coworkers studied 95 cerebral revascularization candidates and found a modest correlation between neurocognitive deficits and real-world dysfunction. 21 The EC-IC Bypass Study did not report improvement in cognitive function as a secondary outcome. 1 The COSS, in addition to determining whether stroke and death are reduced after bypass, will also assess clinical outcome using Rankin Scale Score, NIH-SS score, modified BI, and SS-QOL Assessment.…”