Neuropsychological predictors of vocational rehabilitation outcomes in individuals with major depression: A scoping review

Bergdolt, Juliane; Sellin, Pauline; Drießen, Martin; Beblo, Thomas; Dehn, Lorenz B.

doi:10.3389/fpsyt.2022.942161

Cited by 3 publications

(2 citation statements)

References 85 publications

(229 reference statements)

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“…Major depressive disorder (MDD) is a major mental disorder with high mortality and disability [ 1 , 2 ]. The most common pathophysiological explanation of MDD relies on the monoamine hypothesis, which indicates that depressive symptoms relate to a lack of neurotransmitters such as serotonin [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

MANF/EWSR1/ANXA6 pathway might as the bridge between hypolipidemia and major depressive disorder

Zheng

Zhao

et al. 2022

Transl Psychiatry

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Major depressive disorder (MDD) involves changes in lipid metabolism, but previous findings are contradictory. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is considered to be a regulator of lipid metabolism. To date, the function of MANF has been studied in many brain disorders, but not in MDD. Therefore, to better understand the role of lipids in MDD, this study was conducted to examine lipid levels in the serum of MDD patients and to investigate the potential function of MANF in MDD. First, the data on total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) in serum from 354 MDD patients and 360 healthy controls (HCs) were collected and analyzed. The results showed that there were significantly lower concentrations of TC and LDL-C in MDD patients compared with HCs, and TC levels were positively correlated with LDL-C levels. Bioinformatics analysis indicated that MANF/EWSR1/ANXA6 pathway might serve as the connecting bridge through which hypolipidemia played a functional role in MDD. Second, to verify this hypothesis, serum samples were collected from 143 MDD patients, and 67 HCs to measure the levels of MANF, EWSR1, and ANXA6 using ELISA kits. The results showed that compared to HCs, MDD patients had a significantly lower level of MANF and higher levels of ANXA6 and EWSR1, and these molecules were significantly correlated with both TC level and Hamilton Depression Rating Scales (HDRS) score. In addition, a discriminative model consisting of MANF, EWSR1, and ANXA6 was identified. This model was capable of distinguishing MDD subjects from HCs, yielded an area under curve of 0.9994 in the training set and 0.9569 in the testing set. Taken together, our results suggested that MANF/EWSR1/ANXA6 pathway might act as the bridge between hypolipidemia and MDD, and these molecules held promise as potential biomarkers for MDD.

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Section: Introductionmentioning

confidence: 99%

MANF/EWSR1/ANXA6 pathway might as the bridge between hypolipidemia and major depressive disorder

Zheng

Zhao

et al. 2022

Transl Psychiatry

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“…Major depressive disorder (MDD) is a common mental disorder with high mortality and disability [1][2][3][4]. Persons with unremitted depression are more likely to commit suicide [5,6].…”

Section: Introductionmentioning

confidence: 99%

Elevated SCN11A concentrations associated with lower serum lipid levels in patients with major depressive disorder

Xu,

Zhao,

Ren

et al. 2024

Transl Psychiatry

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The pathogenesis of major depressive disorder (MDD) involves lipid metabolism. Our earlier research also revealed that MDD patients had much lower total cholesterol (TC) concentrations than healthy controls (HCs). However, it is still unclear why TC decreased in MDD. Here, based on the Ingenuity Knowledge Base’s ingenuity pathway analysis, we found that sodium voltage-gated channel alpha subunit 11A (SCN11A) might serve as a link between low lipid levels and MDD. We analyzed the TC levels and used ELISA kits to measure the levels of SCN11A in the serum from 139 MDD patients, and 65 HCs to confirm this theory and explore the potential involvement of SCN11A in MDD. The findings revealed that TC levels were considerably lower and SCN11A levels were remarkably increased in MDD patients than those in HCs, while they were significantly reversed in drug-treatment MDD patients than in drug-naïve MDD patients. There was no significant difference in SCN11A levels among MDD patients who used single or multiple antidepressants, and selective serotonin reuptake inhibitors or other antidepressants. Pearson correlation analysis showed that the levels of TC and SCN11A were linked with the Hamilton Depression Rating Scales score. A substantial association was also found between TC and SCN11A. Moreover, a discriminative model made up of SCN11A was discovered, which produced an area under a curve of 0.9571 in the training set and 0.9357 in the testing set. Taken together, our findings indicated that SCN11A may serve as a link between low lipid levels and MDD, and showed promise as a candidate biomarker for MDD.

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Cognition and gut microbiota in schizophrenia spectrum and mood disorders: A systematic review

Frileux,

Boltri,

Doré

et al. 2024

Neuroscience & Biobehavioral Reviews

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Neuropsychological predictors of vocational rehabilitation outcomes in individuals with major depression: A scoping review

Cited by 3 publications

References 85 publications

MANF/EWSR1/ANXA6 pathway might as the bridge between hypolipidemia and major depressive disorder

MANF/EWSR1/ANXA6 pathway might as the bridge between hypolipidemia and major depressive disorder

Elevated SCN11A concentrations associated with lower serum lipid levels in patients with major depressive disorder

Cognition and gut microbiota in schizophrenia spectrum and mood disorders: A systematic review

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