Neuropsychological profiles of patients with juvenile myoclonic epilepsy and their siblings: A preliminary controlled experimental video-EEG case series

Iqbal, Nasur; Caswell, Helen; Hare, Dougal Julian; Pilkington, Olga A.; Mercer, Stephen E.; Duncan, Susan E.

doi:10.1016/j.yebeh.2008.12.025

Cited by 76 publications

(68 citation statements)

References 21 publications

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“…A positive correlation between the level of visuo-spatial WM and caudate BP (knowing essential and specific role for the caudate nucleus in WM (Lewis et al, 2004)) support our findings of alterations limited to the midbrain in JME. These data are in accordance with increasing reports about impairment of working memory (Savic et al, 2004;Swartz et al, 1996a;Swartz et al, 1996b) and poor executive functions (concept formation, abstract reasoning, mental flexibility, planning, and organization), (Ciumas et al, 2008;de Araujo Filho et al, 2006;Iqbal et al, 2009;Piazzini et al, 2008;Pulsipher et al, 2009) in patients with JME. Similar findings are sparse in other forms of IGE (Caplan et al, 2008;Davidson et al, 2007).…”

Section: Cognitive Impairmentsupporting

confidence: 92%

The dopamine system in idiopathic generalized epilepsies: Identification of syndrome-related changes

et al. 2010

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Section: Cognitive Impairmentsupporting

confidence: 92%

The dopamine system in idiopathic generalized epilepsies: Identification of syndrome-related changes

et al. 2010

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“…6,7,9,29,30 However, they also demonstrate performance reductions that are consistent with extrafrontal dysfunction. Although our JME group performed less well on specific cognitive measures, they were otherwise cognitively high functioning.…”

Section: Neuropsychological and Brain Region Relationshipsmentioning

confidence: 97%

“…6 More recently, further impairments in executive functions have been highlighted. [7][8][9][10] JME is also characterized by the absence of detectable structural brain abnormalities using MRI or CT. 11 Focal abnormalities have been detected using volumetry or automated voxel-based morphometry (VBM) of structural MRI scans. 12 These changes, however, have shown marked spatial variability, 13 albeit with a tendency toward changes in frontal cortex.…”

mentioning

confidence: 99%

Focal structural changes and cognitive dysfunction in juvenile myoclonic epilepsy

O’Muircheartaigh¹,

Vollmar²,

Barker³

et al. 2011

Neurology

156

148

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Objective: The aim of this study was to determine if there were focal cortical abnormalities in juvenile myoclonic epilepsy (JME) using neuropsychological investigations and MRI. Methods:Twenty-eight patients with JME and a large sample of healthy controls were assessed using a series of neuropsychological tests as well as structural and diffusion tensor MRI (DTI). DTI measures assessed fractional anisotropy (FA) within a white matter skeleton.Results: Neuropsychological testing indicated subtle dysfunctions in verbal fluency, comprehension, and expression, as well as nonverbal memory and mental flexibility. Utilizing whole-brain voxel-based morphometry for gray matter MRI data and tract-based spatial statistics for white matter diffusion MRI data, we found reductions in gray matter volume (GMV) in the supplementary motor area and posterior cingulate cortex and reductions in FA in underlying white matter of the corpus callosum. Supplementary motor area FA predicted scores in word naming tasks and expression scores. Posterior cingulate cortex GMV and FA predicted cognitive inhibition scores on the mental flexibility task. Conclusions:The neuropsychological, structural, and tractography results implicate mesial frontal cortex, especially the supplementary motor area, and posterior cingulate cortex in JME. Juvenile myoclonic epilepsy (JME) is a common type of idiopathic generalized epilepsy (IGE), accounting for approximately 4%-11% of all epilepsies. It is characterized by an age-specific onset of epilepsy with myoclonic jerks, generalized tonic-clonic seizures, and, less frequently, absences. 1A typical abnormality detected by EEG is bilateral spike or polyspike and wave complexes, often strongest in frontocentral areas.2 Further focal or asymmetric abnormalities on EEG occur in approximately 30% of patients. 3,4 Fifty years ago patients with JME were noted to have personality traits previously considered to characterize frontal lobe pathology.5 Studies examining neuropsychological aspects have identified a range of deficits, for example impaired performance on tasks of mental flexibility and cognitive speed. 6 More recently, further impairments in executive functions have been highlighted. 7-10

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“…Iqbal et al [46] examined expressive language, memory, and higher executive tasks in JME patients as compared with their siblings and a normal control group under video-EEG conditions. Eight sibling pairs, one in each pair with JME, were compared with 16 controls matched for age, sex, ethnicity, and educational level.…”

Section: Genetic Predisposition Theorymentioning

confidence: 99%

Cognitive Disorders in Juvenile Myoclonic Epilepsy

Шилкина¹,

Artyukhov²,

Moskaleva³

et al. 2017

Int J Biomed

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Cognitive disorders are often associated with epilepsy and are a result of a combination of various factors. This review describes scientific advances in the field of cognitive disorders in patients with juvenile myoclonic epilepsy (JME), the most common form of idiopathic generalized epilepsy. Data in this review were collected through an extensive literature search of available full-text publications in PubMed and eLIBRARY.RU databases. We selected four theories of the origin of cognitive impairment in JME patients for discussion, based on the analysis of available studies. Our findings highlight the etiological heterogeneity of cognitive disorders in JME and the importance early screening for them. (Int J Biomed. 2017; 7(1):9-14.)

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Neuropsychological profiles of patients with juvenile myoclonic epilepsy and their siblings: A preliminary controlled experimental video-EEG case series

Cited by 76 publications

References 21 publications

The dopamine system in idiopathic generalized epilepsies: Identification of syndrome-related changes

The dopamine system in idiopathic generalized epilepsies: Identification of syndrome-related changes

Focal structural changes and cognitive dysfunction in juvenile myoclonic epilepsy

Cognitive Disorders in Juvenile Myoclonic Epilepsy

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