Neuropsychopharmacological Profile of the Methanolic Fraction of Bryophyllum pinnatum Leaf Extract

Abstract

Neuropharmacological studies were conducted in experimental animals (rats and mice) with the methanolic fraction of Bryophyllum pinnatum leaf extract. The fraction produced alteration of behaviour pattern, caused dose-dependent potentiation of pentobarbitone sleeping time and had significant analgesic activity. Significant reduction of exploratory behaviour and loss of residual curiosity were among the effects observed with the fraction. The observations suggest that the methanolic fraction of Bryophyllum pinnatum possesses a potent CNS depressant action.

Analgesic and anti-inflammatory activity of hydroalcoholic extract of Piper betle leaves in experimental animals

“…13,14 In our study HEPBL showed to inhibit the pain by both the central as well as peripheral mechanism. Hence we assume that the analgesic action of HEPBL could have been mediated through narcotic mechanism.…”

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

“…Using the chemical method described above, the aqueous extract and stigmast-4,20(21),23-trien-3-one (47) significantly reduced the number of contractions by 80.16 % and 75.72 %, respectively. The methanolic fraction also showed a significant reduction of contractions [40,80]. At doses of 100-300 mg/kg b. w., the aqueous leaf extract increased the pain threshold in rats in the hot plate assay, and reduced phenylbenzoquinone-induced writhing in mice [97].…”

“…Some of these neuropharmacological effects were tested in Swiss mice applying a methanolic fraction. The GABA content in the brain was estimated after i. p. administration, and the methanolic fraction led to an increase in brain GABA concentration [80]. The compounds responsible for the neurological activity are not definitively known, but a neurosedative effect of bersaldegenin-1,3,5-orthoacetate (3) was demonstrated in mice, whereby strongly sedative activity was observed with doses of 0.1-0.5 mg/kg b. w. However, higher doses resulted in paralysis and muscle contractions [23].…”

“…Oral doses up to 3 g/kg b. w. in mice and rats led to no signs of toxicity [104]. In mice, an intraperitoneally administered methanolic fraction led to no deaths up to 2500 mg/kg b. w. in mice, but their behavior changed with concentrations > 100 mg/kg b. w. [80] (See also …”

Analgesic Effect of Methanol Leaf Extract of <i>Alstonia Boonei</i> De Wild (Apocynaceae)

“…The tail flick test measures complex responses to acute nociceptive activity and is one of the models used for studying centrally acting analgesics [14]. The extract showed a potent activity on this model, similar to the effect of morphine.…”