Neuroselective transcutaneous electrical stimulation reveals neuronal sensitization in atopic dermatitis

Ozawa, Masashi; Tsuchiyama, Kenichiro; Gomi, Rumiko; Kurosaki, Fumio; Kawamoto, Yuji; Aiba, Setsuya

doi:10.1016/j.jaad.2008.11.900

Cited by 21 publications

(16 citation statements)

References 22 publications

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“…The role of regulatory T cells in AD remains controversial. Although some investigators suggest that Treg cells from AD patients are numerically and functionally similar to those from normal individuals, other studies reported that patients with AD have increased number of Treg cells in the peripheral blood and skin compared to control subjects (Ozawa et al, 2009;Szegedi et al, 2009). Here, we showed that AD-like skin lesions in NC/Nga mice may cause expansion of Treg cells to compensate the AD response and the Treg cells were controlled by both KRG and pimecrolimus.…”

Section: Discussionmentioning

confidence: 99%

Korean red ginseng extract ameliorates skin lesions in NC/Nga mice: An atopic dermatitis model

Lee

Cho

2011

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Korean red ginseng extract ameliorates skin lesions in NC/Nga mice: An atopic dermatitis model

Lee

Cho

2011

Journal of Ethnopharmacology

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“…Atopics reported a higher incidence of sensory irritation, i.e. stinging and itching [7,8,67]. Therefore, we examined the influence of atopy on the neurosensory response to water and lactic acid for the two genotypes.…”

Section: Discussionmentioning

confidence: 99%

Role of TNF‐α polymorphism ‐308 in neurosensory irritation

Davis

Visscher

Wickett³

et al. 2011

Intern J of Cosmetic Sci

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Neurosensory cutaneous discomfort in response to topical products is common, yet the relationship between symptoms such as stinging and visible irritation is currently unclear. The presence of a polymorphism at position -308 on the TNF-α gene has been associated with skin irritation, i.e., erythema, dryness. Individuals with a G to A transition (AA/GA genotypes) have a lower threshold to experimentally induced irritation than those with the wild type (G allele, GG genotype). We investigated the effect of this polymorphism on neurosensory irritation (NSI). DNA genotyping was used to determine the allele type amongst a population of health care workers. The neurosensory response to lactic acid and water on the nasolabial folds and hands was assessed using a quantitative lactic acid sting test. Both genotypes had a more intense response to lactic acid compared with water on the face. The AA/GA genotypes had directionally higher scores from lactic acid (P = 0.1) and significantly higher stinging intensities from water (P = 0.001) on the face. For the hands, stinging intensities were higher for lactic acid and water amongst the AA/GA genotypes (P = 0.03 and 0.006 respectively). NSI to lactic acid was significantly higher on the face than on the hands (P < 0.05). Our findings indicate that subjects with the A transition at position -308 on the TNF-α gene experience more intense NSI with common ingredients, i.e., lactic acid and water, than those with the wild type. TNF-α polymorphism -308 may account for some of the inter-individual variability in response to skin care practices.

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“…This phenomenon appears to be related to an impaired skin barrier in patients with the extrinsic form [77]. In contrast to healthy subjects, neuroselective transcutaneous electrical stimulation preferentially evokes itch in atopics [78]. Clinical evaluation revealed hypersensory sensitivity in atopics [79], which is correlated with sleep disorders [80].…”

Section: Atopic Dermatitis and Skin Neurophysiologymentioning

confidence: 94%

Atopic Dermatitis and the Nervous System

Miséry

2010

Clinic Rev Allerg Immunol

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Due to the narrow associations between the skin, immune system, and nervous system, nerve endings are very important in the pathophysiology of inflammatory dermatoses and especially in atopic dermatitis. Many neurotransmitters and nerve growth factors that are released in blood or skin are involved in neurogenic inflammation, which dramatically enhance the inflammation induced by immune cells. During times of stress, their release is highly enhanced. In atopic dermatitis lesions, there are many specific changes in skin neurobiology and neurophysiology. These interesting data suggest that novel therapeutic possibilities can be imagined.

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Neuroselective transcutaneous electrical stimulation reveals neuronal sensitization in atopic dermatitis

Cited by 21 publications

References 22 publications

Korean red ginseng extract ameliorates skin lesions in NC/Nga mice: An atopic dermatitis model

Korean red ginseng extract ameliorates skin lesions in NC/Nga mice: An atopic dermatitis model

Role of TNF‐α polymorphism ‐308 in neurosensory irritation

Atopic Dermatitis and the Nervous System

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