Neurotoxicité des agents administrés par voie intrathécale

Evaluation of the clinical and analgesic effects of subarachnoid ketamine-lidocaine administration in goats undergoing mastectomy

“…18 Also, high concentrations of lidocaine administered epidurally or intrathecally may induce temporary or irreversible trauma to the nervous tissue. 18,19 In the present study, the dose was reduced to 1.25 mg/kg to minimize chances of neurotoxicity.…”

Efeitos da administração subaracnóidea de grandes volumes de lidocaína a 2% e ropivacaína a 1% sobre a medula espinhal e as meninges: estudo experimental em cães

“…O transporte axoplasmático rápido é necessário para manter a estrutura e função do neurônio 20 . É possível que o anesté-sico local, em elevadas concentrações, determine bloqueio irreversível no transporte axoplasmático rápido e este fato possa contribuir para o desenvolvimento de paresias e paralisias que se observam após a realização de bloqueios regionais 21 .…”

“…Byers et al, 19 in 1973, studying lidocaine effects on rabbit nerves in an experimental in vitro model, have shown that concentrations as low as 0.6% in a 60-minute contact would block fast axoplasma transport and nervous conduction. Fast axoplasma transport is needed to maintain neuronal structure and function 20 . It is possible that high local anesthetic concentrations would determine irreversible block of the fast axoplasma transport and this could contribute to paresthesias and paralysis seen after regional blockade 21 .…”

Evaluation of segmental dorsolumbar epidural analgesia with ketamine hydrochloride administered by use of nonstyletted multiple-port catheters via the caudal approach in cattle

“…Epidural anesthesia via the dorsolumbar space (L1-2) 7,12 or a segmental subarachnoid epidural via T13-L1 5 carries the potential risk of trauma to the spinal cord from sudden movements of an animal or because the epidural space in this area of Time of ketamine administration was designated as time 0. In several studies, investigators have determined that epidural or subarachnoid administration of lidocaine at high doses and high concentrations induces temporary or irreversible lesions of the nervous tissues 22,23 and hypotension that can be a serious complication in hypovolemic animals. Table 1-Mean ± SD values for cardiovascular variables, respiratory rate, and rectal temperature in 6 bulls receiving ketamine hydrochloride at each of 3 doses (0.3, 0.5, and 0.7 mg/kg) by use of dorsolumbar epidural administration via a caudal approach.…”