Neurotransmitters in key neurons of the hypothalamus that regulate feeding behavior and body weight

Meister, Björn

doi:10.1016/j.physbeh.2007.05.021

Cited by 260 publications

(210 citation statements)

References 51 publications

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“…As described in rats and sheep (Clark et al, 1985;Meister, 2007;Miner, Della-Fera, Paterson, and Baile, 1989;van Dijk and Strubbe, 2003) we found that icv infusion of NPY in female musk shrews results in an acute increase in food intake. The most effective doses of NPY are similar to the doses typically given icv in hamsters, rats and sheep (Clark et al, 1984;Clark et al, 1985;Corp et al, 2001;Kulkosky, Glazner, Moore, Low, and Woods, 1988;Miner et al, 1989).…”

Section: Discussionsupporting

confidence: 75%

Neuropeptide Y influences acute food intake and energy status affects NPY immunoreactivity in the female musk shrew (Suncus murinus)

Bojkowska

Hamczyk

Tsai

et al. 2008

Hormones and Behavior

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Neuropeptide Y (NPY) stimulates feeding, depresses sexual behavior, and its expression in the brain is modulated by energetic status. We examined the role of NPY in female musk shrews, a species with high energetic and reproductive demands; they store little fat, and small changes in energy can rapidly diminish or enhance sexual receptivity. Intracerebroventricular infusion of NPY enhanced acute food intake in shrews, however, NPY had little affect on sexual receptivity. The distribution of NPY immunoreactivity in the female musk shrew brain was unremarkable, but energy status differentially affected NPY immunoreactivity in several regions. Similar to what has been noted in other species, NPY immunoreactivity was less dense in brains of ad libitum shrews and greater in shrews subjected to food restriction. In two midbrain regions, both of which contain high levels of gonadotropin releasing hormone II (GnRH II) which has anorexigenic actions in shrews, NPY immunoreactivity was more sensitive to changes in food intake. In these regions, acute refeeding (90-180 minutes) after food restriction reduced NPY immunoreactivity to levels noted in ad libitum shrews. We hypothesize that interactions between NPY and GnRH II maintain energy homeostasis and reproduction in the musk shrew.

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Section: Discussionsupporting

confidence: 75%

Neuropeptide Y influences acute food intake and energy status affects NPY immunoreactivity in the female musk shrew (Suncus murinus)

Bojkowska

Hamczyk

Tsai

et al. 2008

Hormones and Behavior

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“…It is known that in food-deprived subjects various pathways in addition to those involving orexinergic mechanisms modulate food intake. For example, food deprivation increases immediate-early gene expression in neuropeptide-Y containing neurones of the arcuate nucleus (Cummings et al, 2001), and plasma ghrelin is elevated by food deprivation (Gerard et al, 1990;Meister, 2007).…”

Section: Discussionmentioning

confidence: 99%

Effect of orexin-B-saporin-induced lesions of the lateral hypothalamus on performance on a progressive ratio schedule

et al. 2011

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(2012) Effect of orexin-B-saporin-induced lesions of the lateral hypothalamus on performance on a progressive ratio schedule. Journal of Psychopharmacology, 26 (6 A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription.

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“…Peripheral signals have been shown to modulate the activity of NPY/AGRP and POMC neurons within key appetite regulating nuclei of the hypothalamus, such as the arcuate. These circulating factors include the well-known orexigenic peptide ghrelin, released from the oxyntic cells in the stomach, and the anorexigenic hormones insulin and leptin, released by the pancreas and the fat tissue (5,6). Despite the accumulated knowledge on neuropeptide signaling in the hypothalamus (2,3), little information is available on the integrated mechanism of neuronal activation during appetite regulation and how this circumstance could affect the neuroglial metabolic coupling mechanisms underlying neurotransmission events.…”

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confidence: 99%

Cerebral activation by fasting induces lactate accumulation in the hypothalamus

Violante

Anastasovska

Sanchez-Canon

et al. 2009

Magnetic Resonance in Med

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Obesity is a pandemic syndrome frequently associated with the most prevalent pathologies in developed countries, including diabetes, atherosclerosis, ischemic episodes, and cancer (1). Obesity results from an imbalance in the complex system of peripheral and intrahypothalamic pathways controlling appetite regulation and energy homeostasis (2). The hypothalamic control of energy homeostasis involves interaction between food intake stimulating neurons (orexigenic), expressing neuropeptide Y/agouti-related protein (NPY/AGRP), and food intake inhibiting neurons (anorexigenic), expressing pro-opiomelanocortin/cocaine and amphetamine-regulated transcript (POMC/CART) (3,4). Peripheral signals have been shown to modulate the activity of NPY/AGRP and POMC neurons within key appetite regulating nuclei of the hypothalamus, such as the arcuate. These circulating factors include the well-known orexigenic peptide ghrelin, released from the oxyntic cells in the stomach, and the anorexigenic hormones insulin and leptin, released by the pancreas and the fat tissue (5,6). Despite the accumulated knowledge on neuropeptide signaling in the hypothalamus (2,3), little information is available on the integrated mechanism of neuronal activation during appetite regulation and how this circumstance could affect the neuroglial metabolic coupling mechanisms underlying neurotransmission events. On these grounds, methods providing further insight into hypothalamic metabolism and its disturbances entail considerable interest to improve our understanding, prognosis, and therapy of energy homeostasis and food intake disorders.In vivo and in vitro 1 H and 13 C NMR approaches have been successful in providing a wealth of information on cerebral metabolism and neuroglial interactions during sensory or motor activation (7-10). However, the relatively large voxel sizes involved in the acquisition of in vivo NMR spectra preclude its use in studying the relatively small hypothalamic area, particularly in small rodents. Similarly, the relatively large amounts of cerebral tissue needed to prepare brain extracts for high-resolution 13 C NMR constitute an important limitation for regional studies of hypothalamic processes. Recently, high-resolution magic angle spinning (HR-MAS) spectroscopy has been proposed as a convenient alternative (11). In this technique, the removal of dipolar couplings at the magic angle (54.7°) permits the acquisition of high-resolution spectra from small tissue samples, with similar quality to that only previously achievable via solution spectroscopy. In most cases, 1 H HR-MAS has been used for metabolic profiling of normal and diseased tissues (11), whereas 13 C HR-MAS offers the additional advantage of providing information on the operation of cerebral metabolic pathways and neuroglial coupling mechanisms, under similar conditions to high-resolution 13 C NMR spectroscopy (12) but using smaller tissue biopsies and without the need of solvent extraction. This makes it possible to investigate the oxida-

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Neurotransmitters in key neurons of the hypothalamus that regulate feeding behavior and body weight

Cited by 260 publications

References 51 publications

Neuropeptide Y influences acute food intake and energy status affects NPY immunoreactivity in the female musk shrew (Suncus murinus)

Neuropeptide Y influences acute food intake and energy status affects NPY immunoreactivity in the female musk shrew (Suncus murinus)

Effect of orexin-B-saporin-induced lesions of the lateral hypothalamus on performance on a progressive ratio schedule

Cerebral activation by fasting induces lactate accumulation in the hypothalamus

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