Neurotropic, immunological and gastric effects of low doses of Atropa belladonna L., Gelsemium sempervirens L. and Poumon histamine in stressed mice

Bousta, Dalila; Soulimani, Rachid; Jarmouni, Idrissi Salah; Belon, P; Falla, Jaı̈ro; Froment, Nicolas; Younos, C.

doi:10.1016/s0378-8741(00)00346-9

Cited by 49 publications

(41 citation statements)

References 21 publications

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“…23 The work, published in a major international journal, is highly complex in its possible interpretations. The mice were subjected to stress consisting of a series of electric shocks according to a standardised procedure, with the remedies administered intraperitoneally 30 min prior to the stress, after which various behavioural parameters such as the LD test and the staircase test were immediately measured.…”

Section: Anxiety Modelsmentioning

confidence: 99%

“…Another reason for undertaking a systematic experimental trial of Gelsemium was that this remedy is frequently used in humans for anxiety symptoms, and has already been investigated in studies by other authors which do not, however, always report consistent results. 13,14,16,18,23 In experimental research in homeopathy it is especially important to consolidate new and preliminary data -which can often be unexpected or even contrary to the beliefs of official pharmacology -through statistically solid evidence. We conducted two complete series of experiments testing various Gelsemium dilutions, Assays of homeopathic remedies in rodents P Bellavite et al with small changes and adaptations of methodology: in the first series -the results of which have been recently published 31 and here are further detailed -the LD test was performed the day before the OF on animals (from Harlan Laboratories), which were housed 4 per cage; in the second series of studies (Magnani et al, manuscript in preparation, whose preliminary data are here reported) the LD test was performed the day after the OF test on animals (from Charles River Laboratories), which were housed 2 per cage.…”

Section: Screening Of Six Homeopathic Remediesmentioning

confidence: 99%

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Assays of homeopathic remedies in rodent behavioural and psychopathological models

et al. 2009

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The first part of this paper reviews the effects of homeopathic remedies on several models of anxiety-like behaviours developed and described in rodents. The existing literature in this field comprises some fifteen exploratory studies, often published in non-indexed and non-peer-reviewed journals. Only a few results have been confirmed by multiple laboratories, and concern Ignatia, Gelsemium, Chamomilla (in homeopathic dilutions/potencies). Nevertheless, there are some interesting results pointing to the possible efficacy of other remedies, and confirming a statistically significant effect of high dilutions of neurotrophic molecules and antibodies. In the second part of this paper we report some recent results obtained in our laboratory, testing Aconitum, Nux vomica, Belladonna, Argentum nitricum, Tabacum (all 5CH potency) and Gelsemium (5, 7, 9 and 30CH potencies) on mice using ethological models of behaviour. The test was performed using coded drugs and controls in double blind (operations and calculations). After an initial screening that showed all the tested remedies (except for Belladonna) to have some effects on the behavioural parameters (light-dark test and open-field test), but with high experimental variability, we focused our study on Gelsemium, and carried out two complete series of experiments. The results showed that Gelsemium had several effects on the exploratory behaviour of mice, which in some models were highly statistically significant (p < 0.001), in all the dilutions/dynamizations used, but with complex differences according to the experimental conditions and test performed. Finally, some methodological issues of animal research in this field of homeopathy are discussed. The "Gelsemium model" - encompassing experimental studies in vitro and in vivo from different laboratories and with different methods, including significant effects of its major active principle gelsemine - may play a pivotal rule for investigations on other homeopathic remedies.

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Section: Anxiety Modelsmentioning

confidence: 99%

Section: Screening Of Six Homeopathic Remediesmentioning

confidence: 99%

Assays of homeopathic remedies in rodent behavioural and psychopathological models

et al. 2009

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“…Homeopathic information mimics a pathophysiological stress, because it is able to induce symptoms of pathology, and, in the ‘already-stressed’ and inefficient organism, would re-activate a coherent response. In fact, homeopathy could have a positive effect on stress-induced behavior and on gastric and immunologic alterations in mice (48). Highly diluted histamine shows to be active on blood basophils, on skin inflammation reactions and on sleep patterns in rats (5,49).…”

Section: The Role Of Pathophysiological Statementioning

confidence: 99%

Immunology and Homeopathy. 5. The Rationale of the ‘Simile’

Bellavite

Ortolani

Pontarollo

et al. 2007

Evidence-Based Complementary and Alternative Medicine

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The foundation of homeopathic medicine is the ‘Similia Principle’, also known as the ‘Principle of Similarity’ or also as the ‘Simile’, which reflects the inversion of pharmacological effects in healthy subjects as compared with sick ones. This article describes the inversion of effects, a widespread medical phenomenon, through three possible mechanisms: non-linearity of dose–response relationship, different initial pathophysiological states of the organism, and pharmacodynamics of body response to the medicine. Based on the systemic networks which play an important role in response to stress, a unitary and general model is designed: homeopathic medicines could interact with sensitive (primed) regulation systems through complex information, which simulate the disorders of natural disease. Reorganization of regulation systems, through a coherent response to the medicine, could pave the way to the healing of the cellular, tissue and neuro-immuno-endocrine homeodynamics. Preliminary evidence is suggesting that even ultra-low doses and high-dilutions of drugs may incorporate structural or frequency information and interact with chaotic dynamics and physical-electromagnetic levels of regulation. From the clinical standpoint, the ‘simile’ can be regarded as a heuristic principle, according to which the detailed knowledge of pathogenic effects of drugs, associated with careful analysis of signs and symptoms of the ill subject, could assist in identifying homeopathic remedies with high grade of specificity for the individual case.

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“…-d'autres activités apoptotique, antitumorale, antibacté-rienne, antivirale, cardiovasculaire [3,11,21] ; -et de manière précise, la recherche du profil pharmacologique sédatif/anxiolytique dans une plante réputée par sa sédation dans la pratique médicale traditionnelle [7,23].…”

Section: Contexte De La Recherche Sur Les Plantes Médicinales Au Marocunclassified

L’Institut national des plantes médicinales et aromatiques au service du développement de la phytothérapie au Maroc

Bousta

Ennabili

2011

Phytothérapie

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Au Maroc, la phytothérapie est une pratique très ancienne ; elle y doit énormément à la médecine « araboislamique », même si des non-musulmans, juifs et chrétiens notamment, ont joué un rôle important. Les connaissances empiriques se sont transmises verbalement à travers les générations et se sont enrichies grâce à la situation géogra-phique stratégique bien connue du Maroc (diversité bioclimatique et brassage des civilisations à travers l'histoire). À l'heure actuelle, les plantes médicinales peuvent nous apporter des solutions intéressantes aux contraintes liées à la santé surtout dans des pays en voie de développement. La promotion de la phytothérapie nous permettra de sauvegarder le savoir de nos ancêtres qui tend à disparaître. De par ses missions, l'Institut national des plantes médicinales et aromatiques-Maroc, tend à contribuer à l'élaboration de nouveaux médicaments naturels en étroite collaboration avec des décideurs de ce secteur pour sauvegarder la biodiversité végétale d'une part, et contrôler l'innocuité et la qualité des sous-produits de la médecine traditionnelle d'autre part.Abstract: In Morocco, phytotherapy is an ancient practice, which owes greatly to the "Arabo-Islamic" medicine, even if non-Muslims, Jews and Christian particularly, have played an important part in this regard. Empirical knowledge has been passed down orally through the generations and has been enriched thanks to the strategic geographical situation of Morocco (bioclimatic diversity and civilizations brewing through history). Currently, traditional medicine can give us interesting solutions to the constraints related to health especially in developing countries. The promotion of phytotherapy will help us to save the knowledge of our ancestors, which tends to disappear. Through its missions, the National Institute of Medicinal and Aromatic PlantsMorocco attempts to contribute to the development of new natural drugs, closely with decision-makers from this sector to protect plant biodiversity, and control the safety and quality of sub-products used in traditional medicine.

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Neurotropic, immunological and gastric effects of low doses of Atropa belladonna L., Gelsemium sempervirens L. and Poumon histamine in stressed mice

Cited by 49 publications

References 21 publications

Assays of homeopathic remedies in rodent behavioural and psychopathological models

Assays of homeopathic remedies in rodent behavioural and psychopathological models

Immunology and Homeopathy. 5. The Rationale of the ‘Simile’

L’Institut national des plantes médicinales et aromatiques au service du développement de la phytothérapie au Maroc

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