Neutrophil activation by plasma opsonized polymeric microspheres: inhibitory effect of Pluronic F127

Jackson, John K.; Springate, Christopher M. K.; Hunter, William L.; Burt, Helen M.

doi:10.1016/s0142-9612(00)00034-x

Cited by 57 publications

(42 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We suggest that the increased inflammatory responses we observed (cell infiltration, cell proliferation and proteoglycan loss) on injection of microspheres in the small size range (1 -20 mm) into rabbit joints were likely caused by the large phagocytozable fraction of microspheres injected (that is, those less than about 5 mm in size) [19]). Phagocytosis of small particulates into synovial macrophages is accompanied by cell activation and some local inflammation [34,35]. An in vitro study of collagenase production by synovial fibroblast cell cultures incubated with latex particles demonstrated that the ability of latex particles to induce collagenase was strongly dependent on particle size [36].…”

Section: Discussionmentioning

confidence: 99%

Intra-articular treatment of arthritis with microsphere formulations of paclitaxel: biocompatibility and efficacy determinations in rabbits

Liggins

Cruz²,

Min

et al. 2004

Inflamm. res.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Intra-articular treatment of arthritis with microsphere formulations of paclitaxel: biocompatibility and efficacy determinations in rabbits

Liggins

Cruz²,

Min

et al. 2004

Inflamm. res.

View full text Add to dashboard Cite

show abstract

“…4,5 Several other pathways for the generation of reactive oxygen species (ROS) have been reported, including as a consequence of xanthine and NADPH oxidase activity, prostanoid metabolism, ischemic reperfusion conditions and phagocytic respiratory burst activity. 6,7 In recent years, various strategies for antioxidant supplementation have been adopted in an attempt to attenuate the damage caused by exercise. 2,8,9 Taurine, 2-aminoethanesulphonic acid, is one of the most abundant free amino acids in mammalian cells.…”

Section: Introductionmentioning

confidence: 99%

Taurine supplementation decreases oxidative stress in skeletal muscle after eccentric exercise

Silva

Silveira

Ronsani

et al. 2010

Cell Biochem. Funct.

View full text Add to dashboard Cite

Infrequent exercise, typically involving eccentric actions, has been shown to cause oxidative stress and to damage muscle tissue. High taurine levels are present in skeletal muscle and may play a role in cellular defences against free radical-mediated damage. This study investigates the effects of taurine supplementation on oxidative stress biomarkers after eccentric exercise (EE). Twenty-four male rats were divided into the following groups (n = 6): control; EE; EE plus taurine (EE + Taurine); EE plus saline (EE + Saline). Taurine was administered as a 1-ml 300 mg kg(-1) per body weight (BW) day(-1) solution in water by gavage, for 15 consecutive days. Starting on the 14th day of supplementation, the animals were submitted to one 90-min downhill run session and constant velocity of 1·0 km h(-1) . Forty-eight hours after the exercise session, the animals were killed and the quadriceps muscles were surgically removed. Production of superoxide anion, creatine kinase (CK) levels, lipoperoxidation, carbonylation, total thiol content and antioxidant enzyme were analysed. Taurine supplementation was found to decrease superoxide radical production, CK, lipoperoxidation and carbonylation levels and increased total thiol content in skeletal muscle, but it did not affect antioxidant enzyme activity after EE. The present study suggests that taurine affects skeletal muscle contraction by decreasing oxidative stress, in association with decreased superoxide radical production.

show abstract

“…For this kind of application, requirements are the nano/micro overall size and a large water volume fraction to preserve the conformational state of the drug payload. [8][9][10][11]13 The interaction with cells is one of the processes occurring as soon as the microgels are injected in the bloodstream. 14 Devices based on soft matter are attractive because of their unique chemical and physical versatility for conjugating molecules able to promote adhesion to targeted cells and to allow local drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Temperature-Sensitive Poly(vinyl alcohol)/Poly(methacrylate-co-N-isopropyl acrylamide) Microgels for Doxorubicin Delivery

2009

View full text Add to dashboard Cite

Microgels based on poly(vinyl alcohol), PVA, grafted with methacrylate side chains, MA, incorporating N-isopropylacrylamide, NiPAAm, monomer, were prepared by water-in-water emulsion polymerization method. These systems exhibit a spherical shape and a volume-phase transition, that is, shrinking, below physiological temperature. The behavior of these microgels were studied with respect to their average size and size distribution, swelling, and release properties. It was observed that the stirring speed is a key parameter for controlling the amount of incorporated NiPAAm, the particle size and the sharpness of the volume-phase transition. The volumephase transition temperature, VPPT, of the microgels was evaluated around 38 and 34°C for microgels with a NiPAAm/methacrylate molar ratio of 0.8 and 2.4, respectively. Water uptake increased with the amount of NiPAAm monomer present in the polymer network. In vitro biocompatibility of microgels was assessed with respect to NIH3T3 mouse fibroblasts. O-Succinoylated microgels were loaded with doxorubicin by exploiting the favorable electrostatic interaction between negatively charged microgel surface and positively charged doxorubicin. The drug release was influenced by the microgels surface/volume ratio. At physiological temperatures, above the VPTT exhibited by these systems, the release was enhanced by the specific area increase. This study provides the background for the design of an injectable device suitable for the controlled delivery of doxorubicin based on the volume-phase transition of microgels.

show abstract

Neutrophil activation by plasma opsonized polymeric microspheres: inhibitory effect of Pluronic F127

Cited by 57 publications

References 32 publications

Intra-articular treatment of arthritis with microsphere formulations of paclitaxel: biocompatibility and efficacy determinations in rabbits

Intra-articular treatment of arthritis with microsphere formulations of paclitaxel: biocompatibility and efficacy determinations in rabbits

Taurine supplementation decreases oxidative stress in skeletal muscle after eccentric exercise

Temperature-Sensitive Poly(vinyl alcohol)/Poly(methacrylate-co-N-isopropyl acrylamide) Microgels for Doxorubicin Delivery

Contact Info

Product

Resources

About