Neutrophil-endothelial cells modulation in diabetic patients undergoing coronary artery bypass grafting

Chello, Massimo; Mastroroberto, Pasquale; Cirillo, Francesco; Bevacqua, Egidio; Carrano, A; Perticone, Francesco; Marchese, Antonietta R.

doi:10.1016/s1010-7940(98)00222-x

Cited by 14 publications

(11 citation statements)

References 28 publications

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“…Enhanced vesiculation of leukocyte could account for the result, as shown by increased levels of CD45-and CD66-b-positive microparticles in these patients. Consistent with the involvement of neutrophil activation, several studies have reported upregulation of adhesion molecules on neutrophil from diabetic patients (34,35).…”

Section: Diabetes Vol 51 September 2002mentioning

confidence: 57%

Type 1 And Type 2 Diabetic Patients Display Different Patterns of Cellular Microparticles

Sabatier

Darmon

Hugel³

et al. 2002

Diabetes

355

243

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The development of vasculopathies in diabetes involves multifactorial processes including pathological activation of vascular cells. Release of microparticles by activated cells has been reported in diseases associated with thrombotic risk, but few data are available in diabetes. The aim of the present work was to explore the number and the procoagulant activity of cell-derived microparticles in type 1 and 2 diabetic patients. Compared with age-matched control subjects, type 1 diabetic patients presented significantly higher numbers of platelet and endothelial microparticles (PMP and EMP), total annexin V-positive blood cell microparticles (TMP), and increased levels of TMP-associated procoagulant activity. In type 2 diabetic patients, only TMP levels were significantly higher without concomitant increase of their procoagulant activity. Interestingly, in type 1 diabetic patients, TMP procoagulant activity was correlated with HbA 1c , suggesting that procoagulant activity is associated with glucose imbalance. These results showed that a wide vesiculation process, resulting from activation or apoptosis of several cell types, occurs in diabetes. However, diabetic patients differ by the procoagulant activity and the cellular origin of microparticles. In type 1 diabetic patients, TMP-procoagulant activity could be involved in vascular complications. Moreover, its correlation with HbA 1c reinforces the importance of an optimal glycemic control in type 1 diabetes.

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Section: Diabetes Vol 51 September 2002mentioning

confidence: 57%

Type 1 And Type 2 Diabetic Patients Display Different Patterns of Cellular Microparticles

Sabatier

Darmon

Hugel³

et al. 2002

Diabetes

355

243

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown that glucose may contribute to the increased monocyte adherence to endothelium in diabetes (25)(26)(27)(28). It has been proposed that the effect of glucose on monocyte adhesion may occur via mechanisms involving the upregulation of endothelial and/or leukocyte adhesion molecules (25,26,28,51,52), the activation of NF-B, and the generation of ROS (27). Our results showing that blockade of LOX-1 completely abolished glucose-induced monocyte adhesion to endothelial cells demonstrate a new role for LOX-1-mediator of the stimulatory effect of glucose on monocyte adhesion.…”

Section: Discussionmentioning

confidence: 99%

Glucose Enhances Endothelial LOX-1 Expression

Sawamura

Renier

2003

Diabetes

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Endothelial dysfunction is an early and key determinant of diabetic vascular complications that is elicited at least in part by oxidized LDL (oxLDL). The recent observation that lectin-like oxLDL receptor-1 (LOX-1) expression is increased in the vascular endothelium of diabetic rats suggests a role for LOX-1 in the pathogenesis of diabetic vascular dysfunction. Because postprandial plasma glucose has been recently proposed as an independent risk factor for cardiovascular diseases in patients with diabetes, we evaluated, in the current study, the in vitro effect of high glucose on LOX-1 expression by human aortic endothelial cells (

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“…Increased expression of MAC‐1 can be caused by acute hyperglycemia, and might result from impaired neutrophil actin polymerization. It was observed that elevated expression of MAC‐1 could contribute to the pathogenesis of diabetic complications by enhancing adhesion between neutrophils and endothelial cells.…”

Section: Neutrophil‐derived Effector Molecules and Type 1 Diabetesmentioning

confidence: 99%

“…It was observed that elevated expression of MAC-1 could contribute to the pathogenesis of diabetic complications by enhancing adhesion between neutrophils and endothelial cells 54,55 .…”

Section: Adhesion Moleculesmentioning

confidence: 99%

Neutrophils in type 1 diabetes

Huang

Xiao

et al. 2016

J of Diabetes Invest

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Type 1 diabetes is an autoimmune disease that afflicts millions of people worldwide. It occurs as the consequence of destruction of insulin‐producing pancreatic β‐cells triggered by genetic and environmental factors. The initiation and progression of the disease involves a complicated interaction between β‐cells and immune cells of both innate and adaptive systems. Immune cells, such as T cells, macrophages and dendritic cells, have been well documented to play crucial roles in type 1 diabetes pathogenesis. However, the particular actions of neutrophils, which are the most plentiful immune cell type and the first immune cells responding to inflammation, in the etiology of this disease might indeed be unfairly ignored. Progress over the past decades shows that neutrophils might have essential effects on the onset and perpetuation of type 1 diabetes. Neutrophil‐derived cytotoxic substances, including degranulation products, cytokines, reactive oxygen species and extracellular traps that are released during the process of neutrophil maturation or activation, could cause destruction to islet cells. In addition, these cells can initiate diabetogenic T cell response and promote type 1 diabetes development through cell–cell interactions with other immune and non‐immune cells. Furthermore, relevant antineutrophil therapies have been shown to delay and dampen the progression of insulitis and autoimmune diabetes. Here, we discuss the relationship between neutrophils and autoimmune type 1 diabetes from the aforementioned aspects to better understand the roles of these cells in the initiation and development of type 1 diabetes.

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Neutrophil-endothelial cells modulation in diabetic patients undergoing coronary artery bypass grafting

Cited by 14 publications

References 28 publications

Type 1 And Type 2 Diabetic Patients Display Different Patterns of Cellular Microparticles

Type 1 And Type 2 Diabetic Patients Display Different Patterns of Cellular Microparticles

Glucose Enhances Endothelial LOX-1 Expression

Neutrophils in type 1 diabetes

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