Neutrophil gelatinase-associated lipocalin as a potential therapeutic integrator of glycolipid metabolic and inflammatory signaling

Gong, Junhua; Zhu, Ruijie; Gong, Jie; He, Kun; Chen, Jiahai

doi:10.18203/2349-2902.isj20173376

Cited by 3 publications

(3 citation statements)

References 43 publications

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“…Moreover, the conducted research showed that in type 2 diabetes with obesity there is a change in adipose tissue metabolism, expressed by the elevated plasma concentration of NGAL, in relation to the concentration of this regulatory molecule in plasma of subjects with metabolically healthy obesity, which can confirm the role of this adipocytokine in the pathomechanism of obesity leading to the development of insulin resistance, and consequently type 2 diabetes. Recently, increasing evidence has suggested that NGAL not only plays a significant role in both glucose and lipid metabolism, but also modulates immune and inflammatory signaling, which is important in diabetes and metabolic syndrome [10]. The studies have so far indicated that the protein is also linked to the regulation of insulin resistance and development of diabetic vascular disorders, in particular diabetic nephropathy [7,37,38].…”

Section: Discussionmentioning

confidence: 99%

“…NGAL is an important regulator of the PPARγ (peroxisome proliferator-activated receptors γ) activity which is involved in the control of adipogensis and lipogenesis in adipose tissue and liver. Thus, NGAL plays a crucial role in regulating the glycolipids’ and energetic metabolism [10]. The third of the assessed adipokines, cartonectin (CTR3) is a recently discovered protein produced mainly by mature adipocytes [8].…”

Section: Introductionmentioning

confidence: 99%

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Circulating C1q/TNF-Related Protein 3, Omentin-1 and NGAL in Obese Patients with Type 2 Diabetes During Insulin Therapy

Komosińska-Vassev

Olczyk

Kuźnik-Trocha

et al. 2019

JCM

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The aim of the study was to quantify the plasma concentration of omentin-1, neutrophil gelatinase-associated lipocalin (NGAL), and complement C1q tumor necrosis factor-related protein-3 (CTRP3) in obese patients with type 2 diabetes, before introducing insulin therapy, in relation to the plasma expression profiles of these regulatory molecules in the same patients after a 6-month insulin mixture therapy and in obese controls. Elevated plasma NGAL concentrations were found in type 2 diabetic patients as compared with subjects with metabolically healthy obesity. In turn, a 6-month insulin mixture therapy has shown a marked increase in the plasma concentration of omentine-1 and a significant decrease in plasma CTRP3 concentration in obese patients with type 2 diabetes, in relation to the values found in these patients before the implementation of insulin therapy. Insulin mixture therapy has also proved to be an important factor modifying the plasma profile of NGAL, increasing the concentration of this bioactive molecule in the plasma of patients with type 2 diabetes, after 6 months of its use, in relation to the concentration before treatment. The significant changes in the plasma profile of omentin-1, NGAL and CTRP3 during insulin therapy suggest their potential diagnostic utility in monitoring metabolic changes associated with the introduction of insulin treatment in type 2 diabetic patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Circulating C1q/TNF-Related Protein 3, Omentin-1 and NGAL in Obese Patients with Type 2 Diabetes During Insulin Therapy

Komosińska-Vassev

Olczyk

Kuźnik-Trocha

et al. 2019

JCM

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“…Insulin bind to different sites of visfatin noncompetitively, leading to the insulin signaling cascade, increasing glucose uptake, and inhibiting glucose release (17) . The reason for the higher level of serum visfatin in these patients may be due to the following (18)(19)(20)(21) :…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Lipocalin-2 and Visfatin, and Vitamin (D,C, and E) in Serum of Diabetic Patients with Chronic Periodontitis

Anas Qahtan Hamdi,

Entedhar R. Sarhat,

Nagham Hasan Ali

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Objective: The aim of the present study is to verify the hypothesis that salivary and serum lipocalin-2 and visfatin, and vitamin (D,C, and E) used as indicators for chronic periodontitis among DMT2 patients. Subjects and methods: We enrolled 41 type 2 diabetic patients with chronic periodontitis -18 males and 23 females, aged 60± 14 years and 49 controls-26 males and 23 females, aged 61.8 ± 12.5 years. Blood samples were collected after an overnight fast and routine biochemical parameters such as glucose, lipocalin-2 and visfatin, and vitamin (D,C, and E)were determined in all samples. Data were considered significant at a level of p < 0.05.Periodontitis status was established using classic clinical parameters, Plaque index (PI), gingival index (GI), probing depth (PD) and clinical attachment level (CAL). Results: 1) The mean serum of blood glucose, Visfatin, and LCN2 were higher in patients group than in those with normal control group (P<0.001 for all comparisons) ; 2) patients with had a lower Vitamin D,C, and E than those with a normal group (P < 0.001 for all comparisons).Conclusions: The activity of lipocalin-2 and visfatin in saliva and serum can be useful in diagnosis, monitorization and treatment of this disease. Further studies are needed to elucidate the role of lipocalin-2 and visfatin in periodontitis and systemic disease interactions.

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Sex-dependent expression of neutrophil gelatinase-associated lipocalin in aortic stenosis

et al. 2022

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Background Accumulating evidence suggest the existence of sex-related differences in the pathogenesis of aortic stenosis (AS) with inflammation, oxidative stress, fibrosis and calcification being over-represented in men. Neutrophil gelatinase-associated lipocalin (NGAL) is expressed in a myriad of tissues and cell types, and it is associated with acute and chronic pathological processes comprising inflammation, fibrosis or calcification. Sex-dependent signatures have been evidenced for NGAL which expression has been associated predominantly in males to metabolic and cardiovascular disorders. We aimed to analyse sex-related differences of NGAL in AS and its role in the inflammatory and fibrocalcific progression of AS. Methods and results 220 (60.45% men) patients with severe AS elective for surgical aortic valve (AV) replacement were recruited. Immunohistochemistry revealed higher expression of NGAL in calcific areas of AVs and that was validated by qPCR in in 65 (60% men) donors. Valve interstitial cells (VICs) were a source of NGAL in these samples. Proteome profiler analyses evidenced higher expression of NGAL in men compared to women, and that was further validated by ELISA. NGAL expression in the AV was correlated with inflammation, oxidative stress, and osteogenic markers, as well as calcium score. The expression of NGAL, both intracellular and secreted (sNGAL), was significantly deregulated only in calcifying male-derived VICs. Depletion of intracellular NGAL in calcifying male-derived VICs was associated with pro-inflammatory profiles, dysbalanced matrix remodelling and pro-osteogenic profiles. Conversely, exogenous NGAL mediated inflammatory and dysbalanced matrix remodelling in calcifying VICs, and all that was prevented by the pharmacological blockade of NGAL. Conclusions Owing to the over-expression of NGAL, the AV from men may be endowed with higher expression of inflammatory, oxidative stress, matrix remodelling and osteogenic markers supporting the progression of calcific AS phenotypes. The expression of NGAL in the VIC emerges as a potential therapeutic checkpoint, with its effects being potentially reverted by the pharmacological blockade of extracellular NGAL.

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Neutrophil gelatinase-associated lipocalin as a potential therapeutic integrator of glycolipid metabolic and inflammatory signaling

Cited by 3 publications

References 43 publications

Circulating C1q/TNF-Related Protein 3, Omentin-1 and NGAL in Obese Patients with Type 2 Diabetes During Insulin Therapy

Circulating C1q/TNF-Related Protein 3, Omentin-1 and NGAL in Obese Patients with Type 2 Diabetes During Insulin Therapy

Evaluation of Lipocalin-2 and Visfatin, and Vitamin (D,C, and E) in Serum of Diabetic Patients with Chronic Periodontitis

Sex-dependent expression of neutrophil gelatinase-associated lipocalin in aortic stenosis

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