Neutrophil-lymphocyte ratio in patients with ankylosing spondylitis

Abstract

Amaç: Bu çalışmanın amacı, ankilozan spondilit (AS) hastalarındaki inflamasyon ile nötrofil-lenfosit oranı (NLO) arasındaki ilişkiyi belirlemektir. Yöntem: Ankilozan spondilit tanılı 40 hasta ve 30 sağlıklı gönüllü çalışmaya dahil edildi. Tüm veriler yatan ve poliklinik hasta kayıt veritabanından elde edildi. Tüm olguların Bath Ankilozan Spondilit Hastalık Aktivite İndeksi (BAS-DAI), tam kan sayımı (TKS), CRP ve ESH'ı da kapsıyan ayrın-tılı fizik muayene ve laboratuvar bulguları kaydedildi. Lenfosit ve nötrofil sayısı otomatik TKS'nin bir parçası olarak ölçüldü. Bulgular: Akut-faz reaktanı olan CRP ve ESH kontrol grubuna göre hasta grubunda anlamlı olarak daha yüksekti (p 0.05). Sonuç: Bu çalışmada NLO düzeylerinin AS hastalarında sağlıklı bireylere göre anlamlı olarak yüksek olmadığı görüldü. Bu sonuç NLO'nun AS hastalarında sistemik inflamasyonu değerlendirmede uygun bir ölçü birimi olmadı-ğını götermektedir. Bizim elde ettiğimiz bu ön sonuçların daha ileri çalışmalarla tamamlanması gerektiğine inanıyo-ruz. Objective:The purpose of the present study is to determine the association between neutrophil-lymphocyte ratio (NLR) and inflammation in ankylosing spondylitis (AS). Method: Forty patients with ankylosing spondylitis and 30 healthy volunteers were included in the study. All data were obtained from patient registry database from in-patient and out-patient clinics. Detailed physical examination, and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were recorded. Complete blood count (CBC), CRP and ESR were performed recorded as laboratory tests in all participants. Lymphocyte and neutrophil counts were measured as part of the automated CBC. Results: The CRP, which is an acute-phase reactant, and ESR were significantly higher in the patient group than those in the control group (p0.05). Conclusion:We observed that NLR levels weren't significantly higher in AS patients compared to healthy individuals. NLR hasn't seem a reasonable measure to detect systemic inflammation in AS patients. We believe that our preliminary results need to be complemented with further studies.Anahtar Kelimeler: Nötrofil-lenfosit oranı, ankilozan spondilit, enflamasyon, hastalık aktivitesi

Neutrophil/lymphocyte and platelet/lymphocyte ratios as potential markers of disease activity in patients with Ankylosing spondylitis: a case-control study

“…Although the pathogenesis of AS is unknown, some studies have suggested that neutrophils and lymphocytes may play a role in the pathogenesis of AS [1,20]. In the literature, five studies [21][22][23][24][25] showed no significant difference in the NLR when comparing the AS patients with the healthy controls, and similar findings were also obtained with regard to the PLR [21,25,26], which were consistent with the results of this study. However, these results disagreed with the findings of four other studies with regard to the NLR [27][28][29][30] and one study concerning the PLR [24], which might have been related to the involvement of either newly-diagnosed patients with no previous treatment or only patients with active AS in their studies.…”

Investigation of serum iris level and inflammatory markers in Fibromyalgia Syndrome

“…However, NLR has been studied in some rheumatologic diseases. It was found that NLR levels increased [13, 14] in familial Mediterranean fever patients compared to healthy controls, while NLR levels were not different between healthy individuals and patients with ankylosing spondylitis [15, 16]. However, its higher levels were detected in patients with Behçet’s disease relative to healthy controls [12, 17].…”