New 1,3,4‐Thiadiazole Derivatives: Synthesis, Characterization, and Antimicrobial Activity

Abo‐Bakr, Ahmed M.; Hashem, Heba E.

doi:10.1002/jhet.3489

Cited by 15 publications

(5 citation statements)

References 26 publications

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“…It was then allowed to cool in ice water. The solid obtained (Compound III) was filtered and washed thoroughly with hot water then air dried [7][8][9]. The steps for the synthesis are highlighted from Fig.…”

Section: ) Step IIImentioning

confidence: 99%

Synthesis and Evaluation of Antimicrobial Activity of 1, 3, 4-Thiadiazole Analogues for Potential Scaffold

Sahu¹,

Sahu²,

Kalyani³

et al. 2021

J Pharmacopuncture

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Objectives: Pathogenic microbes are causal agents for various types of severe and even lethal infectious diseases. Despite of development in medication, bacterial and fungal infections still persist to be a vital problem in health care. Bacteria and several fungal species have shown resistance to antibiotics used in treatment to current medications. Therefore, it is a considerable field of interest in the design and development of novel compounds with antimicrobial activity. Methods: The compounds bearing a heterocyclic ring play an imperative role among other organic compounds with pharmacological activity used as drugs in human for control and cure of various infections. Thiadiazoles containing nitrogen-sulfur atom as part of their cyclic structure which shown wide-ranging application as structural units of biologically active molecules and are very useful intermediates in Medicinal Chemistry. Results: The effectiveness of the thiadiazole nucleus was established by the drugs currently used for the treatment of various infections. 1,3,4-Thiadiazoles and some of their derivatives are widely studied because of their broad spectrum of pharmacological activities. Conclusion:In the present work, a series of 1,3,4-Thiadiazole derivatives were synthesized by cyclization of a group of various benzaldehyde with thiosemicarbazide in the presence of various reagent like FeCl 3 , HCHO by losing a molecule of water. These derivatives were found to possess prominent antimicrobial activity.

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Section: ) Step IIImentioning

confidence: 99%

Synthesis and Evaluation of Antimicrobial Activity of 1, 3, 4-Thiadiazole Analogues for Potential Scaffold

Sahu¹,

Sahu²,

Kalyani³

et al. 2021

J Pharmacopuncture

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“…The tested compounds exhibited higher to moderate activity in comparison with ceftriaxone at concentration 30 mg/discs. Compounds 14, 15, and 17 showed higher activity against bacteria E. coli, and compounds 15, 16, 17, and 18 showed higher activity against Enterococcus bacteria [50]. 1, 3, 4-thiadiazole-based thioglycosides were synthesized and evaluated for antimicrobial activity against several strains.…”

Section: Antibacterial and Antifungal Activitiesmentioning

confidence: 99%

1,3,4-Thiadiazole Derivatives as an Antimicrobial: An Update

Sawarkar

Singh

Shrivastav

et al. 2021

JPRI

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Persistent and uncontrolled use of antibiotics results in development of bacterial resistant. The situation is getting worsen day by day and scientists are investigating thousands of potentially active drugs like molecule in laboratories around the world every day in search of effective antibiotics. During last decade considerable attention was given to five-member heterocyclic moieties while designing new antimicrobial agents. One of important heterocycle is five-membered 1,3,4-thiadiazole with unique bioisosteric properties displaying unusually wide spectrum of biological activities. This comprehensive review represent the recent 1,3,4-thiadiazole and its derivatives, which can be considered as potential antimicrobial agents in the period of 2015 and onwards. This review may help the medicinal chemists to develop new leads possessing 1,3,4-thiadiazole nucleus with higher efficacy and reduced side effects.

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“…The higher activity of the mentioned compounds is mainly due to the presence of Schiff bases, thiol groups, pyrazole rings, triazole rings, and imide rings within the structure of 1,3,4thiadiazole. 43 A series of novel N-(5-(ethylthio)-1,3,4-thiadiazol-2yl)-2-(5-methyl-6-thioxo-1,3,5-thiadiazinan-3yl)acetamide derivatives 50a-p (Scheme 26) were designed, synthesized and the antimicrobial activities of all the target compounds against Xanthomonas oryzae pv. oryzicola, X. oryzae pv.…”

Section: Therapeutic Studiesmentioning

confidence: 99%

A Review on Synthesis, Therapeutic, and Computational Studies of Substituted 1, 3, 4 Thiadiazole Derivatives

Shamroukh

Hegab²

2020

Egypt. J. Chem.

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Several studies have been reported on 1,3,4-thiadiazole and their derivatives because of their wide range of therapeutic activities. Many drugs containing thiadiazole derivatives are available in market such as acetazolamide, methazolamide, sulphamethazole, cefazoline. This review article highlights the recently synthesized 1,3,4-thiadiazole possessing important therapeutic activities and Computational Studies.

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New 1,3,4‐Thiadiazole Derivatives: Synthesis, Characterization, and Antimicrobial Activity

Cited by 15 publications

References 26 publications

Synthesis and Evaluation of Antimicrobial Activity of 1, 3, 4-Thiadiazole Analogues for Potential Scaffold

Synthesis and Evaluation of Antimicrobial Activity of 1, 3, 4-Thiadiazole Analogues for Potential Scaffold

1,3,4-Thiadiazole Derivatives as an Antimicrobial: An Update

A Review on Synthesis, Therapeutic, and Computational Studies of Substituted 1, 3, 4 Thiadiazole Derivatives

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