Synthesis and Evaluation of Antimicrobial Activity of 1, 3, 4-Thiadiazole Analogues for Potential Scaffold

Abstract

Objectives: Pathogenic microbes are causal agents for various types of severe and even lethal infectious diseases. Despite of development in medication, bacterial and fungal infections still persist to be a vital problem in health care. Bacteria and several fungal species have shown resistance to antibiotics used in treatment to current medications. Therefore, it is a considerable field of interest in the design and development of novel compounds with antimicrobial activity. Methods: The compounds bearing a heterocyclic ring play an imperative role among other organic compounds with pharmacological activity used as drugs in human for control and cure of various infections. Thiadiazoles containing nitrogen-sulfur atom as part of their cyclic structure which shown wide-ranging application as structural units of biologically active molecules and are very useful intermediates in Medicinal Chemistry. Results: The effectiveness of the thiadiazole nucleus was established by the drugs currently used for the treatment of various infections. 1,3,4-Thiadiazoles and some of their derivatives are widely studied because of their broad spectrum of pharmacological activities. Conclusion:In the present work, a series of 1,3,4-Thiadiazole derivatives were synthesized by cyclization of a group of various benzaldehyde with thiosemicarbazide in the presence of various reagent like FeCl 3 , HCHO by losing a molecule of water. These derivatives were found to possess prominent antimicrobial activity.

Novel Thiadiazole-Based Molecules as Promising Inhibitors of Black Fungi and Pathogenic Bacteria: In Vitro Antimicrobial Evaluation and Molecular Docking Studies

“…The biological properties of the thiadiazole ring are multifarious due to it having a wide range of pharmacological actions in which 1,3,4-thiadiazole derivatives are one of the most studied thiadiazole isomers, although 1,3,4-triazole derivatives have few therapeutic measures currently in use during medical practice (e.g., antibacterial activity and carbonic anhydrase inhibitory activity). In contrast, its antibacterial activity has been investigated, and other antimicrobial properties, such as antifungal and antituberculosis abilities, may also be explored [ 43 ]. Former investigations have discovered that thiadiazole compounds have a variety of medicinal properties, including analgesic, antimicrobial, antitumor, anticonvulsant, and anti-hepatitis B activity [ 25 , 44 ].…”

Extraction and Clarification of Orange Wax Obtained from Waste of the Citrus Industry

“…[ 15,25 ] They are used in several protective and lubricating products, such as preservatives, emollients, and thickeners. [ 26 ] Lipsticks, [ 27 ] sunscreens, [ 28 ] creams, [ 29 ] ointments, [ 30 ] lotions, [ 31 ] and hair gels [ 32 ] are some examples of products available on the market that contain this material. [ 15,33 ]…”

Synthesis, Characterization and Evaluation of Antimicrobial Activity of Few New Heterocyclic Compounds Derived from Nicotinic Acid

“…Aromatic ring due to the presence of two double bonds; the Hantzsch-Widman nomenclature using for the name thiadiazole. 15 Derivatives of thiadiazole are four isomeric forms: 1,2,3-thiadiazole; 1,2,4-thiadiazole; 1,2,5-thiadiazole; and 1,3,4-thiadiazole. Derivatives of 1,3,4-thiadiazole show the most important therapeutic ability.…”