“…Investigations of the effects of reactor parameters and operating conditions such as the geometry of the tank, impeller type, size and location, impeller rotation speed and gas flow rate on the reactor characteristics including flow regimes and patterns, gas hold-up, power-consumption, mixing time and mass-transfer coefficient between the phases have been carried out for decades (Ford et al 2008;Joshi et al 2011a; Kumaresan and Joshi 2006;Miller 1974;Nienow et al 1985;Nienow 1998;Parasu-Veera, Patwardhan, and Joshi 2001;Rewatkar et al 1993;Sawant and Joshi 1979). For large-scale, tall-thin, industrial gas-liquid STRs, multiple impellers are usually preferred over a single impeller because multiple impellers can have better gas utilization due to the high residence time of gas bubbles, maintain homogeneity in the reactor, provide high surface-to-volume ratio and offer lower shear than single-impeller STRs for shear-sensitive systems (Ahmed et al 2010;Dutta and Pangarkar 1995;Himmelsbach et al 2006;Kasat and Pandit 2004;Khopkar et al 2006;Shewale and Pandit 2006;You et al 2014). However, the complexity of the flow in STRs with multiple impellers increases with increasing number of impellers as any change in the reactor parameters, such as tank aspect ratio, number, type, size, location and configuration of impellers and operating conditions, may influence the reactor operating characteristics significantly.…”