New antagonists of platelet-activating factor containing 2-oxazolidinone or 2-morpholinone

Ring‐Closure Reactions through Intramolecular Displacement of the Phenylselenonyl Group by Nitrogen Nucleophiles: A New Stereospecific Synthesis of N‐Tosyl and N‐Benzoyl‐1,3‐oxazolidin‐2‐ones from β‐Hydroxyalkyl Phenyl Selenides

“…The physical and spectral data for compound 25 b have already been reported in the literature. [39] (5R)-5-[(benzyloxy)methyl]-1,3-oxazolidin-2-one (25 a): [40] Yield: 84 %, oil; [a] Reductive hydrolysis of 25 a: LiAlH 4 (1 m solution, 2 mL) was added dropwise to a solution of 25 a (0.207 g, 1 mmol) in dry THF (10 mL) at 0 8C. The mixture was stirred at room temperature for about 1 h and was then refluxed for 1 h. Methanol was added to the cooled reaction mixture, and this was then dried over sodium sulfate and concentrated at reduced pressure.…”

Design, synthesis and antidiabetic evaluation of oxazolone derivatives

“…Oxazole plays very vital role in the development of various biologically active agents such as analgesic, 12 antiinflammatory, 13 antidepressant, 14 anticancer, 15 antimicrobial, antidiabetic and antiobesity. 16,17 Oxazol-5-ones contain * For correspondence numerous reactive sites allowing for a diverse set of possible modifications. This diverse reactivity makes them excellent substrates for their use in diversity oriented synthesis.…”

Synthesis of New Bisphosphonate and Bisphosphonic Acid Derivatives and Heterocyclic and Dialkylcarbamoyl Oxazolone Derivatives with Anticancer and Antischistosomal Activity

“…Moreover, nitrogen-, sulfur-or oxygencontaining five-and six-membered heterocyclic compounds have enormous significance in the field of medicinal chemistry. Oxazolones play a very vital role in the manufacturing of various biologically active drugs with analgesic [4], anti-inflammatory [5], antidepressant [6], anticancer [7], antimicrobial, antidiabetic, and anti-obesity activity [8,9]. In view of this, and in continuation of our work in organophosphorus chemistry [ 10 -16], it was of considerable interest to synthesize new 1,1-bisphosphonate, 1,1-bisphosphonic acid c 2011 Verlag der Zeitschrift für Naturforschung, Tübingen · http://znaturforsch.com and heterocyclic oxazolone derivatives to obtain potent biologically active compounds.…”

“…The observed coupling constants of H b (J H b H a = J H b H c , ca. [6][7][8] indicate the syn form, rather than the anti configuration which would give rise to larger coupling constants (9)(10)(11)(12)(13)(14)(15).…”