New Anti-inflammatory Triterpene Esters and Glycosides from Alstonia scholaris

Abstract

: Phytochemical studies on the ethanolic extract of aerial parts of Alstoniascholaris lead to the isolation of two new triterpenoid of the lanostanetype,lanosta 5ene,24-ethyl-3-O-β-D-glucopyranoside(1), lanosta,5ene,24-ethyl-3-O-β-D-glucopyranosideester(2)and new ursane type triterpenoidmethylester, 12-ursene-2,3,18,19-tetrol,28 acetate (nighascholarene)(3),together with seven known triterpenes, betuline,triterpeneof the lupane type, alstoprenyol(4), 3β-hydroxy-28-β-acetoxy-5-olea triterpene (5),α-amyrin acetate (6), α-amyrin (7), lupeol acetate (8), 3β-hydroxy-24-nor-urs-4,12,28-triene triterpene (9) and ursolic acid (l0). The triterpenoid structures of these colorless compounds were deduced from the 1H and 13C-NMR data, and in particular from the application of two-dimensional 1H, 13C correlation experiments as well as by comparison with reported literature data.This study deals with isolation and structural elucidation ofnaturalnewtriterpenoidestersandglycosides with anti-inflammatory activity.

Pharmaceutical Application of Bio-actives from Alstonia Genus: Current Findings and Future Directions

“…Sultana et al isolated ten triterpenoid derivatives (32-41) from the ethanolic extract of A. scholaris aerial parts (Fig. 14.5) and evaluated the anti-inflammatory potential of newly isolated phytochemical, nighascholarene (34), ursane type triterpenoid methyl ester (100 mg/kg), by carrageenan-induced paw edema test in Wistar rats (Sultana et al 2019). Compound 34 resulted in 44% inhibition in the paw edema, while indomethacin resulted in 85% inhibition (positive control).…”