New approach for determination of Phenylephrine HCl in Pure and Pharmaceutical Formulation using a various Microextraction Methods

Kareem, Nagham K.; Thani, Mohammed Z.; Al-Rawi, Khalid F.

doi:10.52711/0974-360x.2022.00275

Cited by 5 publications

(3 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Phenylephrine-HCl (PPH) represents a type of sympathomimetics drugs that directly affects and stimulates alpha-1 adrenergic receptors found in blood vessels and smooth muscles (1). PPH is usually indicated to raise blood pressure in unstable patients with hypotension, especially causes from septic shock, and its nasal drops are used to treat symptoms such as itching of the nose and throat, sneezing and runny nose (2).…”

Section: Introductionmentioning

confidence: 99%

Development of Two Simple Spectrophotometric Methods to Assay Phenylephrine-HCl as Pure Form And in Its Drug Forms

HAMEED,

ALİ

2023

Journal of the Turkish Chemical Society Section A: Chemistry

View full text Add to dashboard Cite

This work includes the development of two spectrophotometric methods which are sensitive, accurate, stable, and has good recovery for the determination of phenylephrine-HCl as free form and in the pharmaceutical preparations. In the method (A), phenylephrine is oxidized by potassium permanganate in a basic solution of sodium hydroxide and the bluish-green color of the resulting manganate (MnO 42- ) is measured at wavelength 610 nm, which is linearly proportional to the amount of phenylephrine-HCl. Method (B), is involved the oxidation of phenylephrine-HCl by using an excess amount of N-bromosuccinimide in an acidic medium of hydrochloric acid solution, the remaining (unreacted) amount of N-bromosuccinimide is used to bleach indigo carmine dye and the absorbance of the blue color of the remaining dye is measured at the wavelength of 610 nm. which is directly proportional to the concentration of phenylephrine-HCl. The molar absorptivity coefficients of methods (A) and (B) are estimated and equal to 1.5722×10 4 and 5.5191×10 4 L/mol.cm, respectively. Beer’s law of the both methods are linear in the concentration ranges 0.2–8.0 µg/mL (method A) and 0.2–3.5 µg/mL (method B). The relative standard deviation values of methods (A) and (B) are also found to be better than 0.0286 and 0.0114, respectively. The two proposed methods are applied to estimate phenylephrine-HCl in injection and drop.

show abstract

Section: Introductionmentioning

confidence: 99%

Development of Two Simple Spectrophotometric Methods to Assay Phenylephrine-HCl as Pure Form And in Its Drug Forms

HAMEED,

ALİ

2023

Journal of the Turkish Chemical Society Section A: Chemistry

View full text Add to dashboard Cite

show abstract

“…*Corresponding author at: Department of Chemistry, College of Science, Tikrit University, Sallah-Aldin, Iraq ORCID:https://orcid.org/0000-0000-00000-;Tel:+9647816689990 E-mail address: Araf.I.Jabbar.chem869@st.tu.edu.iq liquid chromatography-mass spectrometry (LC-MS) [14,15], and fluorescence spectrophotometry [16][17][18], were available for the analysis of CFX. Dispersive Liquid-Liquid Micro-Extraction (DLLME) and Salt-Induced Liquid-Liquid Micro-Extraction (SIHLLME) have many advantages such as speed, low cost and safety [19][20][21][22][23]. The aim of the study was the simultaneous determination of CFX using inclusion complex with 2-hydroxypropyl-β-cyclodextrin as a reagent in combination with the DLLME and SIHLLME as extraction methods.…”

Section: Introductionmentioning

confidence: 99%

Determination of Cefixime inclusion complex with 2-hydroxypropyl-β-cyclodextrin and extraction using DLLME and SIHLLME

Jabbar¹,

Khaleel²,

Thani³

2023

JUAPS

View full text Add to dashboard Cite

Micro-extraction techniques with UV-Vis measurement have been developed and validated for the analysis of Cefixime (CFX) in pure and pharmaceutical form. In this work, the DLLME and SIHLLME methods were employed for the extraction, enrichment and evaluation of CFX in pure form and pharmaceuticals using UV-Vis spectroscopy at 274 and 282 nm, respectively. The type of dispersive and extraction solvents and their volumes, pH, the amount of salt, and the centrifuging time were among the experimental variables that were accomplished. Under the perfect conditions, the procedures were linear in the range of 5.0-100.0 and 1.0-15.0 μg/mL, with a correlation coefficient of determination (R 2 ) of 0.9963 and 0.9984 for DLLME and SIHLLME, respectively, LOD was 3.7 and 0.11 µg/mL. Recovery of the target analyte in pharmaceuticals was 96.5%-102.4%. The method can be easily applied to CFX concentrations above this value, but needs further improvements before it can be used in pharmacokinetic studies where more sensitive methods can be found. A simple, inexpensive, accurate, and precise spectrophotometric assay of CFX in pharmaceutical formulations was developed and validated following DLLME and SIHLLME for routine analysis.

show abstract

“…Various analytical methods were utilized to determine the TMP containing spectral techniques [11][12][13][14][15], liquid chromatography [16], HPLC [17], and the electrical method [18,19]. The dispersive liquid-liquid microextraction (DLLME) has many advantages like rapid, low cost, and safety [20,21]. The aim of this work was for the simultaneous spectrophotometric determination of TMP by ion-pair complex with alizarin yellow as a reagent combine with LLE and DLLME methods.…”

mentioning

confidence: 99%

Ion-Pair Complex of Trimethoprim with Alizarin Yellow and its Determination and Extraction by LLE and DLLME

Jabbar¹,

Thani²,

Khaleel³

2023

Tikrit J. Pure Sci.

View full text Add to dashboard Cite

For the analysis of trimethoprim medication in its pure form and pharmaceutical formulations, precise and accurate microextraction techniques with UV-Vis measurement have been developed and confirmed. In this study, LLE and DLLME procedures were utilized for the separation, pre-concentration, and evaluation of trimethoprim in pure form and pharmaceutical preparations by UV-Vis spectroscopy at 390 nm. The method was validated and applied to the evaluation of trimethoprim in pharmaceutical formulations. Several experimental factors containing the type of dispersive and extraction solvents and their volumes, pH, temperature, and centrifuging time were carried out. Under the ideal conditions, the procedures were linear in the range of 2–45 and 1-10 mg/L, with a coefficient of determination (R2) of 0.9961 and 0.9992 for LLE and DLLME, respectively. The limit of detection (LOD) was 1.52 and 0.21 mg/L. Recovery of the target analyte in pharmaceutical formulations was 99.3%-104.9%.

show abstract

New approach for determination of Phenylephrine HCl in Pure and Pharmaceutical Formulation using a various Microextraction Methods

Cited by 5 publications

References 23 publications

Development of Two Simple Spectrophotometric Methods to Assay Phenylephrine-HCl as Pure Form And in Its Drug Forms

Development of Two Simple Spectrophotometric Methods to Assay Phenylephrine-HCl as Pure Form And in Its Drug Forms

Determination of Cefixime inclusion complex with 2-hydroxypropyl-β-cyclodextrin and extraction using DLLME and SIHLLME

Ion-Pair Complex of Trimethoprim with Alizarin Yellow and its Determination and Extraction by LLE and DLLME

Contact Info

Product

Resources

About