New arenavirus isolated in Brazil

Coimbra, Terezinha Lisieux Moraes; Nassar, E.S.; Souza, Luiza Terezinha Madia de; Ferreira, Ivani B.; Rocco, Iray Maria; Burattini, Marcelo Nascimento; Rosa, A.P.A. Travassos da; Vasconcelos, Pedro F. C.; Pinheiro, F. P.; LeDuc, James W.; Rico-Hesse, Rebeca; Gonzalez, Jean‐Paul; Tesh, Robert B.; Jahrling, Peter B.

doi:10.1016/s0140-6736(94)91226-2

Cited by 152 publications

(50 citation statements)

References 6 publications

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“…She eventually developed conjunctival petechiae, hematemesis, vaginal bleeding, increased sleepiness, tremors, difficulty walking, and generalized tonic-clonic seizures; she died of the infection on the fourth day of hospital admission. The necropsy indicated necrosis of and hemorrhage in various organs 1 .…”

Section: Four Documented Cases Of Sabiá Virus Infectionmentioning

confidence: 99%

“…Arenaviruses are enveloped negativestranded RNA viruses [1][2][3] . In addition to the SABV, the New World complex includes the following 17 viruses: Allpahuayo (Peru), Amapari (Brazil), Bear Canyon (California, USA) Chapare (Bolivia), Cupixi (Brazil), Flexal (Brazil), Guanarito (Venezuela), Junin (Argentina), Latino (Bolivia), Machupo (Bolivia), Oliveros (Argentina), Parana (Paraguay), Pichinde (Colombia), Pirital (Venezuela), Tacaribe (Trinidad), Tamiami (Florida, USA), and Whitewater Arroyo (Southwestern USA.).…”

Section: Basic Aspects Of the Sabiá Virusmentioning

confidence: 99%

“…The potential of the Allpahuayo, Amapari, Cupixi, Parana, Pirital, Latino, and Oliveros viruses to cause diseases in humans is unknown (reviewed in Koma et al 11 ). In general, symptoms caused by the SABV are abdominal and epigastric pain, bleeding gums, conjunctival petechiae, conjunctivitis, cough, diarrhea, difficulty walking, fever, headache, hematemesis, hemorrhage, leukopenia, malaise, myalgia, nausea, somnolence, sore throat, tonic-clonic seizures, tremors, vomiting, weakness, and shock 1,12 .…”

Section: Basic Aspects Of the Sabiá Virusmentioning

confidence: 99%

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Keeping track of hidden dangers - The short history of the Sabiá virus

Ellwanger

2017

Rev. Soc. Bras. Med. Trop.

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Emerging infectious diseases are a global threat. In countries like Brazil, where biodiversity is high and public health conditions in terms of infrastructure and medical care are often precarious, emerging diseases are particularly worrisome. The lack of monitoring strategies to identify pathogens with the potential to cause outbreaks or epidemics is another problem in Brazil and other developing countries. In this article, we present the history of the Sabiá virus (SABV), a pathogen that was described in the 1990s in Brazil. Several aspects of the biology and ecology of the SABV remain unknown. The SABV has the potential to cause hemorrhagic fever in humans. To date, four cases of human infections have been reported worldwide; two were naturally acquired (both in Brazil), whereas the other two were linked to occupational exposure in the laboratory environment (one in Brazil and one in the USA). In this review, we summarize the basic biological and ecological characteristics of the SABV. This is the first work to gather all available data on the historical aspects involving the cases of SABV infection along with an update on its characteristic features.

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Section: Four Documented Cases Of Sabiá Virus Infectionmentioning

confidence: 99%

Section: Basic Aspects Of the Sabiá Virusmentioning

confidence: 99%

Section: Basic Aspects Of the Sabiá Virusmentioning

confidence: 99%

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Keeping track of hidden dangers - The short history of the Sabiá virus

Ellwanger

2017

Rev. Soc. Bras. Med. Trop.

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“…All NW arenaviruses that have been shown to cause hemorrhagic fevers in humans so far belong to clade B: Junín virus (JUNV), Machupo virus (MACV), Guanarito virus (GTOV), Sabia virus (SABV), and Chapare virus (CHAV). These viruses are responsible for hemorrhagic fever outbreaks in South America with case fatality rates of 10 to 35% (6)(7)(8)(9)(10)(11)(12). In addition to these five pathogenic viruses, there are three more viruses in clade B: Tacaribe virus (TCRV), Amapari virus (AMAV), and Cupixi virus (CPXV) (Fig.…”

Section: Importancementioning

confidence: 99%

Human and Host Species Transferrin Receptor 1 Use by North American Arenaviruses

Zong

Fofana

Choe

2014

J Virol

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At least five New World (NW) arenaviruses cause hemorrhagic fevers in South America. These pathogenic clade B viruses, as well as nonpathogenic arenaviruses of the same clade, use transferrin receptor 1 (TfR1) of their host species to enter cells. Pathogenic viruses are distinguished from closely related nonpathogenic ones by their additional ability to utilize human TfR1 (hTfR1). Here, we investigate the receptor usage of North American arenaviruses, whose entry proteins share greatest similarity with those of the clade B viruses. We show that all six North American arenaviruses investigated utilize host species TfR1 orthologs and present evidence consistent with arenavirus-mediated selection pressure on the TfR1 of the North American arenavirus host species. Notably, one of these viruses, AV96010151, closely related to the prototype Whitewater Arroyo virus (WWAV), entered cells using hTfR1, consistent with a role for a WWAV-like virus in three fatal human infections whose causative agent has not been identified. In addition, modest changes were sufficient to convert hTfR1 into a functional receptor for most of these viruses, suggesting that a minor alteration in virus entry protein may allow these viruses to use hTfR1. Our data establish TfR1 as a cellular receptor for North American arenaviruses, highlight an "arms race" between these viruses and their host species, support the association of North American arenavirus with fatal human infections, and suggest that these viruses have a higher potential to emerge and cause human diseases than has previously been appreciated. IMPORTANCEhTfR1 use is a key determinant for a NW arenavirus to cause hemorrhagic fevers in humans. All known pathogenic NW arenaviruses are transmitted in South America by their host rodents. North American arenaviruses are generally considered nonpathogenic, but some of these viruses have been tentatively implicated in human fatalities. We show that these North American arenaviruses use the TfR1 orthologs of their rodent host species and identify TfR1 polymorphisms suggesting an ongoing "arms race" between these viruses and their hosts. We also show that a close relative of a North American arenavirus suggested to have caused human fatalities, the Whitewater Arroyo species complex virus AV96010151, uses human TfR1. Moreover, we present data that imply that modest changes in other North American arenaviruses might allow these viruses to infect humans. Collectively, our data suggest that North American arenaviruses have a higher potential to cause human disease than previously assumed.

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“…Only two cases of Sabiá virus infection (both in Brazil) have been reported (2). One was a naturally acquired infection in an agricultural engineer who was probably infected by exposure to an infected rodent (the natural reservoir of other known arenaviruses).…”

Section: Editorial Notementioning

confidence: 99%

Arenavirus Infection—Connecticut, 1994

1994

JAMA

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New arenavirus isolated in Brazil

Abstract: A new arenavirus,

Cited by 152 publications

References 6 publications

Keeping track of hidden dangers - The short history of the Sabiá virus

Keeping track of hidden dangers - The short history of the Sabiá virus

Human and Host Species Transferrin Receptor 1 Use by North American Arenaviruses

Arenavirus Infection—Connecticut, 1994

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