New Biomarkers as Prognostic Factors for Cardiovascular Complications in Type 2 Diabetic Patients

Ahmed, Hanaa H.; Shousha, Wafaa Gh.; El-mezayen, Hatem A.; Emara, Ibrahim A.; Hassan, Marwa E.

doi:10.1007/s12291-018-0784-4

Cited by 5 publications

(12 citation statements)

References 28 publications

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“…Mean age of the participants ranged between 11 and 67 years. Twenty-one studies recruited both gender, 17,19,[22][23][24]27,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46] four were conducted only in men, 18,21,25,47 and three used female subjects. 20,26,48 Included studies were conducted in participants with T1DM, 17,32,40 T2DM 22,23,26,27,38,39,41,[43][44][45][46][47] , and patients with IGT.…”

Section: Overview Of Included Studiesmentioning

confidence: 99%

“…18,21,24,42 Seven studies enrolled normal weight (BMI<24.9) subjects, 23,32,33,36,44-46 13 recruited overweight participants (24.9≤BMI≤29.9) 17,18,21,22,25,27,34,38,39,41,43,47,48 and 6 were conducted on obese subjects 20,24,26,35,37,42 but 2 studies did not mention baseline BMI. 19,40 Two studies were cross sectional 35,37 and the others were casecontrol. [17][18][19][20][21][22][23][24][25][26][27][32][33][34]36,[38][39][40][41][42][43][44]…”

Section: Overview Of Included Studiesmentioning

confidence: 99%

“…19,40 Two studies were cross sectional 35,37 and the others were casecontrol. [17][18][19][20][21][22][23][24][25][26][27][32][33][34]36,[38][39][40][41][42][43][44][45][46][47][48] Based on the NOS, 10 studies ranked as high-quality 23,27,32,35,37,40,41,43,44,47 and the others as were classified as moderate in quality assessment.…”

Section: Overview Of Included Studiesmentioning

confidence: 99%

“…Twenty-eight studies with 2941 participants examined serum omentin level among patients with diabetes (T1DM, T2DM, and IGT) and healthy subjects. [17][18][19][20][21][22][23][24][25][26][27][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48] There was a significant association between serum omentin and diabetes (WMD−1.68; 95% CI, −2.17 to −1.19; P<0.001). There was evidence of heterogeneity between the effect sizes of the included studies (I 2 =96.9% p<0.001).…”

Section: The Association Between Serum Omentin Level and Diabetesmentioning

confidence: 99%

“…14 Based upon previous reports, plasma omentin levels inversely correlate with body mass index (BMI), fat mass, and fasting plasma insulin, and positively with insulin sensitivity, adiponectin, high-density lipoprotein cholesterol, and endothelial function. [15][16][17][18] However, increasing body of literature has shown paradoxical relationships between serum omentin and diabetes with some studies suggesting a significant association between serum omentin level and diabetes [19][20][21][22][23] while others do not support such an association. 18,[24][25][26][27] Currently, there is insufficient evidence showing whether serum omentin is related to diabetes, and determination of this relationship has rarely been conducted.…”

Section: Introductionmentioning

confidence: 99%

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<p>The association between omentin and diabetes: a systematic review and meta-analysis of observational studies</p>

́habi

Sadeghi

Arab

et al. 2019

DMSO

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Aims: A number of studies have examined the association between the serum levels of omentin and diabetes, but the findings have been inconclusive. Herein, we systematically reviewed available observational studies to elucidate the overall relationship between omentin and diabetes, including type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), and impaired glucose tolerance (IGT) among adolescent and adult population. Methods: PubMed, Cochrane's Library, Science Direct, Scopus, Google Scholar, and ISI Web of Science databases were searched for all available literature until January 2019 for studies assessing the association between omentin and diabetes. The Newcastle-Ottawa Quality Assessment Scale was used to assess the quality of each study. Results: A total of 28 articles met the inclusion criteria and were included in our systematic review and meta-analysis. There was a significant association between serum omentin and diabetes (WMD−1.68; 95% CI, −2.17 to −1.19; P<0.001). The result of our subgroup analysis based on participants' health status revealed that omentin was significantly lower in T2DM and IGT subjects but not in T1DM ones compared to healthy controls. Conclusion: We found that serum omentin level is significantly lower in T2DM and IGT patients but not in T1DM ones. These data could be used by clinicians for early diagnosis and management of diabetes. Furthermore, we need more clinical trials to investigate new agents which could influence omentin levels.

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Section: Overview Of Included Studiesmentioning

confidence: 99%

Section: Overview Of Included Studiesmentioning

confidence: 99%

Section: Overview Of Included Studiesmentioning

confidence: 99%

Section: The Association Between Serum Omentin Level and Diabetesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

<p>The association between omentin and diabetes: a systematic review and meta-analysis of observational studies</p>

́habi

Sadeghi

Arab

et al. 2019

DMSO

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Visfatin is negatively associated with coronary artery lesions in subjects with impaired fasting glucose

Xiang

Zhao

et al. 2022

Open Medicine

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It is not determined whether serum visfatin levels are related to the presence and severity of coronary artery disease (CAD) in non-diabetic subjects. In this study, a total of 65 consecutive non-diabetic participants who underwent coronary angiography were enrolled. Serum visfatin and fasting glucose, as well as the serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride, were measured in all participants before the procedure. The extent of coronary artery lesions was determined by Gensini score. Serum visfatin levels were significantly lower in patients with CAD compared to participants with normal coronary arteries. Inversely, the circulating levels of fasting glucose were found to be elevated in patients with CAD compared with the control subjects. Multivariable logistic regression analysis demonstrated that visfatin and impaired fasting glucose (IFG) were independently associated with the presence of CAD in non-diabetics. No significant relationship was found between serum visfatin and fasting glucose levels in IFG subjects. However, there was a negative association between visfatin concentrations and Gensini score in participants with IFG. Both circulating visfatin concentrations and IFG are independently associated with CAD in non-diabetics. Serum visfatin levels are negatively related to the angiographic severity of CAD in subjects with IFG.

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Analysis of Adipokines and some Steroid Hormones in Myocardial Infarction

Yousif

Ismail

2023

Baghdad Sci.J

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The most common cause of death is cardiovascular disease (CVD), with ischemic heart disease being the most notable type. There is a propensity to raise the sensitivity of methods in contemporary laboratory for diagnosing of CVD, and assessing key as CVD bio-indicators. The urgent task is to seek for different indicators as a hopeful tool for early detection and monitoring of myocardial infarction in blood samples only. This study comprised 117 Volunteers, recorded with both genders in the age range of 32-64 years old. The volunteers were categorized into two groups: 67patients of myocardial infarction, other group embraced 50 healthy individuals. The samples of blood were collected and directed for biochemical analysis to evaluate estradiol, testosterone, progesterone, adiponectin, leptin, and lipid profile [total cholesterol, triglycerides, high density lipoprotein (HDL), and low-density lipoprotein (LDL)] levels in each group. The following conclusion can be drawn from this study based on statistical assessment of bio-indicator parameters, significantly reduced of testosterone and HDL (P <0.001) levels in myocardial infarction, within non-significantly elevated P <0.061 of progesterone levels in myocardial infarction patients as compared with healthy individuals. The remaining biochemical tests indicated significantly elevated levels in patients with myocardial infarction such as estradiol (P <0.001), adiponectin (P <0.001), leptin (P <0.001), total cholesterol (P <0.001), triglycerides (P <0.001) and LDL (P <0.001) levels. Adipokines (adiponectin, leptin) and some steroid hormones (estradiol, testosterone) show crucial roles in the improvement of metabolic and cardiovascular diseases and may be utilized as bio-pointer for myocardial infarction exposure, medical conduct and severity. This acknowledgment offers early diagnosis of disease and progression.

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New Biomarkers as Prognostic Factors for Cardiovascular Complications in Type 2 Diabetic Patients

Cited by 5 publications

References 28 publications

<p>The association between omentin and diabetes: a systematic review and meta-analysis of observational studies</p>

<p>The association between omentin and diabetes: a systematic review and meta-analysis of observational studies</p>

Visfatin is negatively associated with coronary artery lesions in subjects with impaired fasting glucose

Analysis of Adipokines and some Steroid Hormones in Myocardial Infarction

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