New clinical presentations of invasive aspergillosis in non-conventional hosts

Abstract

Infections by Aspergillus spp. are most typically associated with invasive pulmonary aspergillosis. However, an increasing number of reports deal with unusual manifestations of invasive aspergillosis. In the lung this may take the form of chronic invasive pulmonary aspergillosis, bronchocentric granulomatosis or tracehobronchitis. A number of extrapulmonary infections have been noted, sometimes in immunocompetent individuals. Examples include vertebral osteomyelitis, primary cutaneous aspergillosis (such as in premature neonates), prosthetic vascular graft infection and infective endocarditis. Early recognition of these entities, prompt initiation of new, highly active antifungal therapies and adjunctive surgical management may improve the prognosis of these conditions.

True mycotic false aneurysm due to aspergillus: Three lesions in two cases and literature review

“…Bacterial infection of vascular prosthetic grafts is a serious event but occurs in less than 3% of patients with grafts in place [3]. Fungal infections of vascular grafts are even less frequent [2,[4][5][6][7][8][9][10][11][12][13][14][15][16].…”

Aspergillus flavus Brain Abscesses Associated with Hepatic Amebiasis in a Non-neutropenic Man in Senegal

“…However, in recent years, there has been a significant increase in Aspergillus infections in immunocompetent hosts in which a number of extrapulmonary infections have been observed, including central nervous system aspergillosis. 3 Neuroaspergillosis is an uncommon infection accounting for 5% of all cranial infections but it is associated with an exceedingly high mortality rate that approaches 100%. In most cases, diagnosis is made after death or at the terminal stage of disease.…”

“…The patient had no evidence of sinus disease by CT scan and MRI, and the location of the cerebral abscesses did not suggest nasal or paranasal origin. Moreover, because a few reports described invasive pulmonary aspergillosis in immunocompetent patients, 3 we searched for evidence to support this hypothesis. However, our patient had no evidence of invasive pulmonary aspergillosis by CT scan and histologic post-mortem examinations of the lungs.…”

Schmerzlose kutane Knoten bei einem 61-j�hrigen stammzelltransplantierten Patienten

“…Aspergillusinfektionen sind daher auf Intensivstationen gefürchtet, zumal sie oft sehr schwierig zu diagnostizieren sind. Ihre klinischen Zeichen sind meist uncharakteristisch und serologische Parameter unzuverlässig [6,7]. Am häufigs-ten ist die pulmonale Aspergillose durch Aspergillus fumigatus, aber es kann auch jedes andere Organ betroffen werden, und es können auch andere Aspergillusarten zu gleichartigen Infektionen führen.…”

“…Am häufigs-ten ist die pulmonale Aspergillose durch Aspergillus fumigatus, aber es kann auch jedes andere Organ betroffen werden, und es können auch andere Aspergillusarten zu gleichartigen Infektionen führen. Aspergillusinfektionen der Haut sind dabei eher selten [2,4,6]. Sie können durch direkte Inokulation von außen (bei vorhandener Eintrittspforte) oder durch septische Streuung einer Organaspergillose entstehen [4].…”