New Collagen-Dextran-Zinc Oxide Composites for Wound Dressing

Păunica-Panea, Georgeta; Ficai, Anton; Marin, Minodora Maria; Marin, Ştefania; Albu, Mădălina Georgiana; Constantin, Vlad Denis; Dinu-Pîrvu, Cristina-Elena; Vuluga, Zina; Corobea, Mihai Cosmin; Ghica, Mihaela Violeta

doi:10.1155/2016/5805034

Cited by 47 publications

(27 citation statements)

References 14 publications

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“…Moist wounds are known to heal faster due to the adequate supply of growth factors and other molecules to the healing tissues [ 31 ]. Moreover, it helps to keep excessive exudates [ 32 ]. A good swelling ratio is necessary to provide essential nutrients for the cells [ 33 ] and to deliver antibiotics to the wound bed [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Physicochemical Characterization of Bilayer Hybrid Nanocellulose-Collagen as a Potential Wound Dressing

et al. 2020

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The eminent aim for advance wound management is to provide a great impact on the quality of life. Therefore, an excellent strategy for an ideal wound dressing is being developed that eliminates certain drawbacks while promoting tissue regeneration for the prevention of bacterial invasion. The aim of this study is to develop a bilayer hybrid biomatrix of natural origin for wound dressing. The bilayer hybrid bioscaffold was fabricated by the combination of ovine tendon collagen type I and palm tree-based nanocellulose. The fabricated biomatrix was then post-cross-linked with 0.1% (w/v) genipin (GNP). The physical characteristics were evaluated based on the microstructure, pore size, porosity, and water uptake capacity followed by degradation behaviour and mechanical strength. Chemical analysis was performed using energy-dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectrophotometry (FTIR), and X-ray diffraction (XRD). The results demonstrated a uniform interconnected porous structure with optimal pore size ranging between 90 and 140 μm, acceptable porosity (>70%), and highwater uptake capacity (>1500%). The biodegradation rate of the fabricated biomatrix was extended to 22 days. Further analysis with EDX identified the main elements of the bioscaffold, which contains carbon (C) 50.28%, nitrogen (N) 18.78%, and oxygen (O) 30.94% based on the atomic percentage. FTIR reported the functional groups of collagen type I (amide A: 3302 cm−1, amide B: 2926 cm−1, amide I: 1631 cm−1, amide II: 1547 cm−1, and amide III: 1237 cm−1) and nanocellulose (pyranose ring), thus confirming the presence of collagen and nanocellulose in the bilayer hybrid scaffold. The XRD demonstrated a smooth wavy wavelength that is consistent with the amorphous material and less crystallinity. The combination of nanocellulose with collagen demonstrated a positive effect with an increase of Young’s modulus. In conclusion, the fabricated bilayer hybrid bioscaffold demonstrated optimum physicochemical and mechanical properties that are suitable for skin wound dressing.

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Section: Discussionmentioning

confidence: 99%

Physicochemical Characterization of Bilayer Hybrid Nanocellulose-Collagen as a Potential Wound Dressing

et al. 2020

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“…It was reported that the results were strongly influenced by the nature and concentration of composite components. From the obtained results (performances of the hydrogels, stationary rheometry, porous structure, morphology, and biological behavior), it was observed that the composite based on collagen and dextran with 50% ZnO was the most promising for future applications in wound dressing and as a biomaterial with a high potential for skin regeneration [8].…”

Section: Functionalized Collagen Hydrogels For Wound Healing Applicatmentioning

confidence: 99%

“…One of the significant advantages of a rapid bactericidal action may be that it permits wound healing to proceed without bacterial interference and reduces the likelihood for resistance to develop [7]. New composites, based on collagen and nanoparticles, are currently under research to be used for the wound healing [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Collagen-Nanoparticles Composites for Wound Healing and Infection Control

Grigore

Grumezescu

Holban

et al. 2017

Metals

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Nowadays, the world is facing a serious crisis represented by the rapid emergence of resistant bacteria, which jeopardizes the efficacy of antibiotics. This crisis has been attributed to the overuse and misuse of antibiotics, as well as the cessation of new drug production by the pharmaceutical industry. Therefore, bacterial strains with resistance to multiple antibiotic classes have appeared, such as Staphylococcus aureus, Acinetobacter spp. and Pseudomonas aeruginosa. This review aims to provide an updated summary of the current approach to the treatment of infections due to resistant microorganisms, with a focus on the application of the antimicrobial effects of inorganic nanoparticles in combination with collagen to promote wound healing. In addition, the paper describes the current approaches in the field of functionalized collagen hydrogels capable of wound healing and inhibiting microbial biofilm production.

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“…The rheological measurements were carried out at 37°C±0.5°C. The operational conditions were detailed in our previous studies (Paunica-Panea et al, 2016;Ghica et al, 2012a). The viscosity of the hydrogels was plotted as a function of shear rate and the corresponding curves were obtained.…”

Section: Rheological Analysismentioning

confidence: 99%

Development and Characterization of Indomethacin Loaded Polyvinyl Alcohol Collagen Smart Hydrogels for Burns Injuries

Marin¹,

Ghica²,

Titorencu³

et al. 2016

The International Conference on Advanced Materials and Systems

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Hydrogels play a very important role in burns treatments, alone or in combination with other products, having the capacity to calm and moisturize the wound. Hydrogels are threedimensional structures with interesting properties, having the ability to induce autolysis debridation, to absorb the exudates and to keep the moist of wound healing. The aim of this study was to develop and characterize some new composite materials based on collagen (COLL), polyvinyl alcohol (PVA) and indomethacin (IND), designed to be used for burns injuries and wound healing. Type I fibrillar collagen gel was extracted from calf hide. Indomethacin was added because of anti-inflammatory effect. Hydrogels with various ratios of collagen, PVA and indomethacin were rheologically tested. The collagenic supports obtained by hydrogels lyophilization were investigated by antimicrobial and cytotoxicity tests. The hydrogels presented a pseudoplastic behavior, and the Herschel-Bulkley model best fitted the rheological data. The biological properties, cytotoxicity and antimicrobial tests revealed the possibility of using them in medical application. Based on the hydrogels performance, we could conclude that the antiinflammatory spongious matrices based on collagen and PVA are potentially usable for burn injuries and wound healing.

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New Collagen-Dextran-Zinc Oxide Composites for Wound Dressing

Cited by 47 publications

References 14 publications

Physicochemical Characterization of Bilayer Hybrid Nanocellulose-Collagen as a Potential Wound Dressing

Physicochemical Characterization of Bilayer Hybrid Nanocellulose-Collagen as a Potential Wound Dressing

Collagen-Nanoparticles Composites for Wound Healing and Infection Control

Development and Characterization of Indomethacin Loaded Polyvinyl Alcohol Collagen Smart Hydrogels for Burns Injuries

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