New coumarin and dihydrocinnamic acid derivatives from two malaysian populations of Micromelum minutum

Cytotoxic activity of coumarins fromMicromelum minutum

“…In Indochina, the roasted and crushed leaves are rubbed on to skin irritated by scabies and are also considered to be emmenagogues (Perry, 1980). The species is well known to contain coumarins, but depending on the collection location, the compounds isolated can also be different (Rahmani et al, 1994(Rahmani et al, , 2003Susidarti et al, 2006;Tantivatana et al, 1983;Das et al, 1984). The first sample collected in Peninsula Malaysia yielded micromelin and a new dihydrocinnamic acid derivative of micromelin, while another sample from a different location (also in Peninsular Malaysia) yielded tetracyclic microminutinin and 6-methoxymicrominutinin (Rahmani et al, 1994).…”

Synthesis of Benzofuranofuran Derivatives: Model of Natural Products

“…Pseudosemiglabrin (3) and semiglabrin (4) have anticoagulant and antimalarial activities (2). Microminutinin (5) pertains to a class of compounds that displays in vivo activity in the lymphocytic leukemia test system (3)(4)(5), while several other compounds with the benzofuranofuranone unit, e.g., 6 and 7, have anticoagulant activity (6). Furthermore, very recent theoretical studies have revealed that the five-membered rings of the benzofuranofuran derivatives present complex conformational properties (7).…”

Indonesian Micromelum minutum Leave Extracts and Their Cytotoxic Activities toward Breast Cancer Cell Lines

“…Isolation and identification of active compounds in M. minutum leaves from several countries has been done. M. minutum grown in Malaysia [3]- [5], Thailand [6]- [8], India [7] and Sri Lanka [9] contains coumarin as a main compound. Additionally, other compounds, such as flavonoids and alkaloids, which are known to be active as anticancer agents, are also found in this plant [4], [10], [11].…”