New Destruxins from the Marine‐Derived Fungus Beauveria felina

Lira, Simone Possedente de; Vita-Marques, Aline M.; Seleghim, Mirna Helena Regali; Bugni, Tim S.; LaBarbera, Daniel V.; Sette, Lara Durães; Sponchiado, Sandra Regina Pombeiro; Ireland, Chris M.; Berlinck, Robert G. S.

doi:10.1002/chin.200712195

Cited by 5 publications

(6 citation statements)

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“…A number of new compounds have been previously reported by us (Hernandez et al, 2000;Hernandez et al, 2004;Lira et al, 2006;Pimenta et al, 2010). We have subsequently developed a multi-screening approach in order to obtain and select bioactive extracts from marine-derived fungi culture media (Vita-Marques et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Evaluating methods for the isolation of marine-derived fungal strains and production of bioactive secondary metabolites

Kossuga

Romminger

Xavier

et al. 2012

Rev. bras. farmacogn.

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Abstract:In the present investigation we evaluate methods for the isolation and growth of marine-derived fungal strains in artificial media for the production of secondary metabolites. Inoculation of marine macroorganisms fragments in Petri dishes proved to be the most convenient procedure for the isolation of the largest number of strains. Among the growth media used, 3% malt extract showed the best result for strains isolation and growth, and yielded the largest number of strains from marine macroorganisms. The percentage of strains isolated using each of the growth media which yielded cytotoxic and/or antibiotic extracts was in the range of 23-35%, regardless of the growth media used. Further investigation of extracts obtained from different marine-derived fungal strains yielded several bioactive secondary metabolites, among which (E)-4-methoxy-5-(3-methoxybut-1-enyl)-6-methyl-2H-pyran-2-one is a new metabolite isolated from the Penicillium paxilli strain Ma(G)K.

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Section: Introductionmentioning

confidence: 99%

Evaluating methods for the isolation of marine-derived fungal strains and production of bioactive secondary metabolites

Kossuga

Romminger

Xavier

et al. 2012

Rev. bras. farmacogn.

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“…18) Among these, fungi represent an economically significant source of bioactive compounds because they are capable of producing high yields of substances with greatly diverse chemical structures, which exhibit a wide range of activi-ties. [19][20][21][22][23] However, only a small fraction of the estimated fungal biodiversity has been investigated for these compounds and there is great possibility to discover species that produce new bioactive metabolites. 22,23) The pigment melanin is found in organisms from all phylogenetic kingdoms, including fungi, and melanin exhibits thermoregulatory, photoprotective, antimicrobial, antiviral, antioxidant, cytotoxic, and anti-inflammatory activities.…”

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confidence: 99%

Inhibition of Nitric Oxide and Tumour Necrosis Factor-α Production in Peritoneal Macrophages by <i>Aspergillus nidulans</i> Melanin

Gonçalves

Kitagawa

Raddi

et al. 2013

Biological & Pharmaceutical Bulletin

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The naturally occurring pigment, melanin is found in organisms of all phylogenetic kingdoms, including fungi, and exhibits a wide range of biological activities. Our objective was to investigate the effects of melanin extracted from the fungus Aspergillus nidulans on the production of the pro-inflammatory mediators nitric oxide (NO) and tumour necrosis factor-α (TNF-α) in peritoneal macrophages and on the viability of McCoy mouse fibroblasts. The results showed that A. nidulans melanin did not stimulate NO production in macrophages, but it inhibited the NO production in lipopolysaccharide (LPS)-stimulated macrophages by approximately 82%. Similarly, A. nidulans melanin inhibited LPS-stimulated TNF-α production by 52% and showed a slight stimulatory effect on TNF-α production in macrophages. In addition, the toxicity of A. nidulans melanin to McCoy cells was much lesser (IC 50 373.5 2.4 µg/mL) than that of known agents such as cisplatin (IC 50 41.2 µg/mL). The viability of peritoneal macrophages was greater than 90% at the highest melanin concentration tested (100 µg/mL). Thus, the combination of low cytotoxicity and marked inhibition of TNF-α and NO production suggests that A. nidulans melanin has potential as an anti-inflammatory agent and may be used in the future for development of new drugs with therapeutic utility.

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“…Butanone extract of the marine-derived fungus Beauveria feline with cytotoxic and anti-tuberculosis activity led to the isolation of two destruxins, destruxin E chlorohydrin and pseudodestruxin C. Both compounds contained (2S,4R)-5-chloro-2,4-dihydroxypentanoic acid (52) (Lira et al, 2006 (Imamura et al, 1993).…”

Section: Branched Saturated and Unsaturated Fatty Acidsmentioning

confidence: 99%

Paradigm Shifts in Fungal Secondary Metabolite Research: Unusual Fatty Acids Incorporated into Fungal Peptides

Dembitsky¹

2017

Int. J. Curr. Res. Biosci. Plant Biol.

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A b s t r a c t A r t i c l e I n f oThis review is a comprehensive survey of unique, unusual, and rare fatty acids incorporated into natural marine and terrestrial peptides obtained from fungi, fungal endophytes, lichenized ascomycetes, basidiomycetes, and actinomycetes. Lots of fungal peptides display important biological activities of interest, which includes antitumor, antibacterial, antimicrobial, antifungal, phototoxic, HIV inhibitory, immunosuppressive properties, and other pharmacological activities. There is no doubt that they are of great importance, especially in medicinal chemistry and/or pharmaceutical application. This review presents structures of more than 150 fatty acids, incorporated into marine and terrestrial fungal lipopeptides.

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New Destruxins from the Marine‐Derived Fungus Beauveria felina

Cited by 5 publications

References 1 publication

Evaluating methods for the isolation of marine-derived fungal strains and production of bioactive secondary metabolites

Evaluating methods for the isolation of marine-derived fungal strains and production of bioactive secondary metabolites

Inhibition of Nitric Oxide and Tumour Necrosis Factor-α Production in Peritoneal Macrophages by <i>Aspergillus nidulans</i> Melanin

Paradigm Shifts in Fungal Secondary Metabolite Research: Unusual Fatty Acids Incorporated into Fungal Peptides

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