New dressings, including tissue-engineered living skin

Ramos‐e‐Silva, Márcia; Castro, Maria Cristina Ribeiro de

doi:10.1016/s0738-081x(02)00298-5

Cited by 94 publications

(44 citation statements)

References 18 publications

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“…5,6 Hyaluronic acid is a non-sulphated glycosaminoglycan (GAG) that is widely distributed in body tissues. 7 This acid is an extracellular matrix component of tissue that forms a pericellular coat on the surfaces of cells. 8 Hyaluronic acid has been receiving increasing attention as a material for tissue engineering because it is believed to have a supportive effect on progenitor cell development, thus facilitating tissue repair.…”

Section: Introductionmentioning

confidence: 99%

Formulation and characterization of poloxamer 407®: thermoreversible gel containing polymeric microparticles and hyaluronic acid

et al. 2013

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Recebido em 27/11/12; aceito em 24/6/13; publicado na web em 2/8/13The influence of the composition and preparation method on the sol-gel transition temperature (T sol-gel ) and rheological response of poloxamer-based formulations was determined. Manual and more complex mechanical stirring were found to provide similar results. In addition, a linear dependence of T sol-gel on the poloxamer content was observed in the range of concentrations analyzed, and a Poloxamer 407 ® concentration of 18% was selected. The addition of hyaluronic acid did not lead to significant changes in the T sol-gel values. In contrast, the addition of microparticles caused a reduction in T sol-gel without a significant reduction in gel strength, and pseudoplastic characteristics were observed, indicating that a thermoreversible gel was obtained with a rheology suitable for application in the treatment of burn wounds.

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Section: Introductionmentioning

confidence: 99%

Formulation and characterization of poloxamer 407®: thermoreversible gel containing polymeric microparticles and hyaluronic acid

et al. 2013

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“…Even with improved prognosis [2] and progress in the use of biological skin substitutes [3], burns are an important cause of mortality [4]. …”

Section: Introductionmentioning

confidence: 99%

Development of Animal Model for Studying Deep Second-Degree Thermal Burns

Pereira

Lima-Ribeiro

Pontes-Filho

et al. 2012

Journal of Biomedicine and Biotechnology

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Thermal lesions were produced in 12 male Wistar rats, positioning a massive aluminum bar 10 mm in diameter (51 g), preheated to 99°C ± 2°C/10 min. on the back of each animal for 15 sec. After 7, 14, 21, and 28 days, animals were euthanized. The edema intensity was mild, with no bubble and formation of a thick and dry crust from the 3rd day. The percentage of tissue shrinkage at 28 days was 66.67 ± 1.66%. There was no sign of infection, bleeding, or secretion. Within 28 days reepithelialization was incomplete, with fibroblastic proliferation and moderate fibrosis and presence of modeled dense collagen fibers. It is concluded that the model established is applicable in obtaining deep second-degree thermal burns in order to evaluate the healing action of therapeutic agents of topical use.

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“…Another commercial product, MySkin [24], consists of a scaffolding silicon membrane, covered with subconfl uent layer of the cultivated keratinocytes. The keratinocytes of the product Laserskin (Vivoderm) [25] form a confl uent layer on the surface of the hyaluronic micromeshed membrane and are capable of migrating downwards, through the scaffold, to the wound bed.…”

Section: Epidermal Equivalentsmentioning

confidence: 99%

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2015

Biopolym. Cell

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Currently, the development and the implementation of the new biotechnological wound coverings (skin equivalents) designed for temporal or permanent replacement of damaged or destroyed areas of human skin remains extremely actual relevant in clinical practice. Skin equivalents or equivalents of individual skin layers which include alive cells of different types take a special place among the artifi cial wound coverings. They mostly contain two basic types of cells -fi broblasts and keratinocytes (together or separately). Such bioconstructions are usually served as temporary coverings, which supply the damaged skin by biologically active substances and stimulate the regeneration of the patient's own tissues. In this review we consider as commercially available wound coverings and those which are still studied in the laboratories. Until now ideal substitutes of natural skin have not yet created, so the efforts of many researchers are focusing on the solution of this problem. K e y w o r d s: artifi cial skin, skin equivalents or substitutes, wound dermal coverages, tissue engineering, cell, wound.

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New dressings, including tissue-engineered living skin

Cited by 94 publications

References 18 publications

Formulation and characterization of poloxamer 407®: thermoreversible gel containing polymeric microparticles and hyaluronic acid

Formulation and characterization of poloxamer 407®: thermoreversible gel containing polymeric microparticles and hyaluronic acid

Development of Animal Model for Studying Deep Second-Degree Thermal Burns

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