New Insights into Vertebrate Thyroid Hormone Receptor Evolution

Holzer, Guillaume; Laudet, Vincent

doi:10.11131/2017/101287

Cited by 4 publications

(3 citation statements)

References 59 publications

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“…Conservation of THRβ but not THRα is also found for several invertebrate taxa, including Polychaeta (sandworms), Gastropoda, Lingulata (lampshells),Bivalvia, Enteropneusta (Acorn worms), Asteroidea (starfish), Branchiostomidae (lancelet), and Ascidiacea (sea squirts, tunicate) (Table ; Supplemental Data, Figure S5a–d). These SeqAPASS results are concordant with results presented by Holzer and Laudet describing the evolution of thyroid hormone signaling across species.…”

Section: Resultsmentioning

confidence: 99%

Evidence for Cross Species Extrapolation of Mammalian-Based High-Throughput Screening Assay Results

LaLone

Villeneuve

Doering

et al. 2018

Environ. Sci. Technol.

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High-throughput screening (HTS) and computational technologies have emerged as important tools for chemical hazard identification. The US Environmental Protection Agency (EPA) launched the Toxicity ForeCaster (ToxCast) Program, which has screened thousands of chemicals in hundreds of mammalian-based HTS assays for biological activity. The data are being used to prioritize toxicity testing on those chemicals likely to lead to adverse effects. To use HTS assays in predicting hazard to both humans and wildlife, it is necessary to understand how broadly these data may be extrapolated across species. The US EPA Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS; https://seqapass.epa.gov/seqapass/) tool was used to assess conservation of the 484 protein targets represented in the suite of ToxCast assays and other HTS assays. To demonstrate the utility of the SeqAPASS data for guiding extrapolation, case studies were developed which focused on targets of interest to the US Endocrine Disruptor Screening Program and the Organisation for Economic Cooperation and Development. These case studies provide a line of evidence for conservation of endocrine targets across vertebrate species, with few exceptions, and demonstrate the utility of SeqAPASS for defining the taxonomic domain of applicability for HTS results and identifying organisms for suitable follow-up toxicity tests.

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Section: Resultsmentioning

confidence: 99%

Evidence for Cross Species Extrapolation of Mammalian-Based High-Throughput Screening Assay Results

LaLone

Villeneuve

Doering

et al. 2018

Environ. Sci. Technol.

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“…a Annelids are not addressed in this review because no aquatic species are used in standard toxicity tests. b THR and its activation were reported in a thesis with T3 (100 nM) and TRIAC (10 nM; Holzer et al, 2016)…”

Section: Evolution Of Thyroid‐like Hormone Signaling In Invertebratesmentioning

confidence: 93%

Thyroid‐like hormone signaling in invertebrates and its potential role in initial screening of thyroid hormone system disrupting chemicals

Morthorst

Holbech

Crozé

et al. 2022

Integr Envir Assess & Manag

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This review examines the presence and evolution of thyroid-like systems in selected aquatic invertebrates to determine the potential use of these organisms in screens for vertebrate thyroid hormone axis disrupting chemicals (THADCs). Such a screen might support the phasing out of some vertebrate testing. Although arthropods including crustaceans do not contain a functional thyroid signaling system, elements of such a system exist in the aquatic phyla mollusks, echinoderms, tunicates, and cephalochordates. These phyla can synthesize thyroid hormone, which has been demonstrated in some groups to induce the nuclear thyroid hormone receptor (THR). Thyroid hormone may act in these phyla through interaction with a membrane integrin receptor. Thyroid hormone regulates inter alia metamorphosis but, unlike in vertebrates, this does not occur via receptor activation by the ligands triiodothyronine (T3) and thyroxine (T4). Instead, the unliganded nuclear receptor itself controls metamorphosis in mollusks, echinoderms, and tunicates, whereas the T3 derivative tri-iodothyroacetic acid (TRIAC) acts as a THR ligand in cephalochordates. In view of this, it may be possible to develop an invertebrate-based screen that is sensitive to vertebrate THADCs that interfere with thyroid hormone synthesis or metabolism along with interaction with membrane receptors. The review makes some recommendations for the need to develop an appropriate test method.

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“…Finally, the article by Holzer and Laudet [ 15 ] describes the discovery of two additional thyroid hormone receptor (TR) genes in the sea lamprey, Petromyzon marinus. This result is very interesting since P. marinus is an agnathan, a jawless vertebrate, and is an important species for understanding vertebrate evolution.…”

mentioning

confidence: 99%