New Naphthalene-Derivative as Cardioprotector Drug on the Ischemia/Reperfusion Injury

Abstract

There is scarce information about the effects exerted by the naphthalene derivatives on cardiac injury caused by ischemia/reperfusion. In this study, a new naphthalene derivative was synthetized with the objective of evaluating its activity on ischemia/reperfusion injury.The Langendorff technique was used to evaluate the effect of the naphthalene derivative on ischemia/reperfusion injury. Additionally, molecular mechanism involved in the activity exerted by the naphthalene derivative on perfusion pressure and coronary resistance was evaluated by measuring left ventricular pressure in absence or presence of following compounds; propanolol, prazosin, metoprolol, indomethacin and nifedipine. The results showed that the naphthalene derivative reduces infarct size compared with control. Other results showed that the naphthalene derivative significantly increase (p = 0.05) the perfusion pressure and coronary resistance in isolated heart. In addition, other data indicate that the naphthalene derivative increase left ventricular pressure in a dose-dependent manner (0.001 to 100 nM); however, this phenomenon was significantly inhibited by nifedipine at a dose of 1 nM (p = 0.05). In conclusion, these data suggest that naphthalene derivative exert a cardioprotective effect via the calcium channels activation and consequently induces changes in the left ventricular pressure levels. This phenomenon results in decrease of myocardial necrosis after ischemia and reperfusion.

Biological Activity of a Coumarin Derivative on Heart Failure Using an Ischemia/Reperfusion Injury Model

“…Alternative experiments were carried out to determine whether increases in the dose (0.001 to 100 nM) of 4-Me-7-Ph-C could produce changes in the infarct size; the results indicated that coumarin derivative decreased infarct area in a dose-dependent manner compared with the control vehicle. This phenomenon could be achieved through changes in perfusion pressure, a hypothesis supported by other studies indicating that some compounds can exert changes in perfusion pressure [30,31]. Analyzing our data, the biological activity produced by 4-Me-7-Ph-C on perfusion pressure was determined using an isolated rat heart model.…”