New nonsteroidal antiinflammatory agent. 2-Substituted 5- or 6-benzothiazoleacetic acids and their derivatives

Design, Synthesis, and Microbiological Evaluation of New Candida albicans CYP51 Inhibitors

“…The intermediate 6-acetyl-2-butyl-4-methyl-3,4-dihydro-2 H -1,4-benzothiazin-3-one ( 14 ) was prepared starting from 3-amino-4-mercaptoacetophenone . The condensation with racemic 2-bromohexanoic acid in aqueous NaOH followed by acidification with 3 N HCl afforded 13 , which was methylated with MeI and t -BuOK in dry DMF to furnish 14 (Scheme ).…”

Microwave assisted facile one pot synthesis of novel 5-carboxamido substituted analogues of 1,4-benzodiazepin-2-one of medicinal interest

“…Based on the earlier precedence in the literature, on the widespread pharmacological activity of morpholine, piperidine, piperazine, pyridine, and pyrimidine, it was assumed that incorporation of these secondary amines to 1,4-benzodiazepine nucleus through the carboxylic ester group could produce interesting series of amide derivatives with enhanced biological activities [11][12][13][14][15][16]. This aroused our interest in these bioactive molecules and prompted us to undertake a study to seek structural modifications by incorporating secondary amine to 1,4-benzodiazepine molecules to generate novel carboxamide derivatives of 1,4-benzodiazepines.…”

Synthesis and Biological Activity of Some New Benzthiazoloazetidin-2-ones and Benzthiazolothizoiidin-4-ones, IV

“…In view of the fact that several benzthiazole derivatives possess useful anti-inflammatory properties [1][2][3][4][5][6], it was of interest to incorporate this molecule into the well known antimicrobial nucleus (azetidinone and/or thiazolidinone) to evaluate these for the pharmacological activity.…”