New Norclerodane Diterpenoids from the Tubers of &lt;i&gt;Dioscorea bulbifera&lt;/i&gt;

Tang, Ying; Xue, Yongbo; Zhou, Lei; Zhang, Jin-wen; Yao, Guangmin; Luo, Zengwei; Du, Guang; Zhang, Yonghui

doi:10.1248/cpb.c14-00057

Cited by 19 publications

(2 citation statements)

References 15 publications

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“…In Myanmar, this plant is used for various cancer diseases such as breast cancer, cervix cancer, etc. Phytochemical studies revealed the presence of alkaloids, anthraquinones, norclerodane diterpenoids, clerodane diterpenoids, flavonoids, phenolic compounds, steroidal saponins, steroidal sapogenins, and glycosides [38][39][40][41][42][43][44][45][46][47][48][49].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Activity of Secondary Metabolite Compounds from Myanmar Medicinal Plants

Tun¹,

Aminah²,

Kristanti³

et al. 2023

Cytotoxicity - Understanding Cellular Damage and Response

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Plants are the storage place for many active ingredients that are currently used in pharmaceuticals. Proofs have been expanded for ages to indicate the profitable capacity of medicinal plants used in various infections, especially for cancer treatment. The plants, Chromolaena odorata (Family Asteraceae), Croton oblongifolius Roxb. (Family Euphorbiaceae), Tinospora cordifolia (Family Menispermaceae), Melastoma malabathricum L. (Family Melastomaceae), and Dioscorea bulbifera (Family Dioscoreaceae) have been used for a long time in Myanmar’s traditional medicine. This study aimed to review systematically the cytotoxic activity of the whole plants and their extracts, fractions, and isolated compounds from these selected medicinal plants. This chapter also be substantiated for additional analysis on phytochemical constituents and pharmacological action of therapeutic plants species in Myanmar.

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Section: Introductionmentioning

confidence: 99%

Cytotoxic Activity of Secondary Metabolite Compounds from Myanmar Medicinal Plants

Tun¹,

Aminah²,

Kristanti³

et al. 2023

Cytotoxicity - Understanding Cellular Damage and Response

View full text Add to dashboard Cite

show abstract

“…It is mostly distributed in Asia and Africa in the wild and commonly naturalized in Central and South America, Nepal, and China. It is a source of diosbulbins as major phytochemicals [ 40 , 44 ]. Other phytochemicals of immense importance include flavonoids, carotenoids, bafoudiosbulbins, steroidal saponins, and essential amino acids [ 6 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

Development of an efficient micropropagation system for Dioscorea bulbifera L. and phytochemical profile of regenerated plants

Bhat

Fayaz

Kumar

et al. 2022

Journal of Genetic Engineering and Biotechnology

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Background The present study was designed to develop an improved in vitro regeneration system for Dioscorea bulbifera using mature nodal explants. Direct organogenesis from nodal segments was achieved by culturing the nodal explants on Murashige and Skoog medium supplemented with 3.5 mgl−1 6-benzylaminopurine (BAP). Shoot multiplication was widely affected by the kind and concentration of plant growth regulators, and the sub-culturing of in vitro regenerated shootlets on fresh medium. After incubation for 4 weeks at optimum BAP concentration, cultures were transferred to secondary medium with BAP (optimized concentration) supplemented with different auxins. Results On medium with 3.5 mgl−1 6-benzylaminopurine, maximum regeneration (87 ± 1.85%) with an average shoot number of 2.0 ± 0.08, and length of 3.5 ± 0.04 cm were observed after 4 weeks of incubation. Maximum number of shoots (3.9 ± 0.21) was observed with 3.5 mgl−1 BAP in combination with 0.75 mgl−1 indole-3-acetic acid. The best root formation was observed on ½ MS medium supplemented with 0.75 mgl−1 α-naphthalene acetic acid, with 4.7 ± 0.03 roots per shoot. The well-rooted plantlets were successfully acclimatized in with 100% survival rate. The plantlets grew well with normal growth, flowering and showed, by High performance thin layer chromatography, almost same number of phytoconstituents compared with the mother plant. Conclusions This is the first study on comparative phytochemical analysis of wild growing and in vitro regenerated plants of D. bulbifera which validates the medicinal and nutritional properties of in vitro raised plants.

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ChemInform Abstract: New Norclerodane Diterpenoids from the Tubers of Dioscorea bulbifera.

et al. 2014

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New Norclerodane Diterpenoids from the Tubers of Dioscorea bulbifera. -The two new compounds diosbulbin N (I) and P (II) and a new naturally occurring compound (III) are isolated from the tubers of Dioscorea bulbifera along with six known norclerodane diterpenoids. Compounds (I)-(III) did not show remarkable cytotoxic activities against five human cancer cell lines studied. -(TANG, Y.; XUE, Y.-B.; ZHOU, L.; ZHANG, J.-W.; YAO, G.-M.; LUO, Z.-W.; DU, G.; ZHANG*, Y.-H.; Chem. Pharm. Bull. 62 (2014) 7, 719-724, http://dx.

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New Norclerodane Diterpenoids from the Tubers of <i>Dioscorea bulbifera</i>

Cited by 19 publications

References 15 publications

Cytotoxic Activity of Secondary Metabolite Compounds from Myanmar Medicinal Plants

Cytotoxic Activity of Secondary Metabolite Compounds from Myanmar Medicinal Plants

Development of an efficient micropropagation system for Dioscorea bulbifera L. and phytochemical profile of regenerated plants

ChemInform Abstract: New Norclerodane Diterpenoids from the Tubers of Dioscorea bulbifera.

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