New peptidic active ingredient to reduce discomfort and painful sensations in sensitive skin

Pauly, G.; Moussou, Philippe; Contet-Audonneau, J.-L.; Danoux, Louis; Freis, Olga; Sabadotto, M.; Benoit, Isabelle; Miséry, Laurent; Rathjens, Andreas

doi:10.1111/j.1468-2494.2009.00532_4.x

Cited by 5 publications

(9 citation statements)

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“…Neurotransmitters, such as substance P, calcitonin gene-related peptide (CGRP) [22] and vasoactive intestinal peptide (VIP) may induce neurogenic inflammation with vasodilatation and mast cell degranulation. Neurogenic inflammation is defined by the release of neuropeptides (by nerve endings) that induces inflammation.…”

Section: Pathophysiologymentioning

confidence: 99%

Sensitive skin

Miséry¹

2013

Expert Review of Dermatology

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Sensitive skin could be defined as the occurrence of erythema and/or abnormal stinging, burning and tingling sensations (occasionally pain or pruritus) in response to multiple factors, which may be physical (UV radiations, heat, cold and wind), chemical (cosmetics, soaps, water and pollutants) and occasionally psychological (stress) or hormonal (menstrual cycle). The diagnosis, pathophysiology, epidemiology and treatment are still under debate. Sensitive skin is most likely due to neurogenic inflammation after the enhanced activation of sensory proteins in keratinocytes and nerve endings. Skin sensitivity is a very frequent condition because it can be detected in approximately half of the population. The treatment is likely a cautious use of cosmetics or the use of cosmetics without preservatives and surfactants or containing inhibitors of neurogenic inflammation.

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Section: Pathophysiologymentioning

confidence: 99%

Sensitive skin

Miséry¹

2013

Expert Review of Dermatology

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“…flavonoids and similar compounds) can minimize inflammatory reactions and modulate vascular reactivity as well as antioxidants. Specific inhibitors of vanilloid receptors have been also shown to be effective .…”

Section: Treatmentmentioning

confidence: 99%

Sensitive skin: an overview

Berardesca

Farage

Maibach

2012

Intern J of Cosmetic Sci

164

144

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SynopsisSensitive skin is a condition of subjective cutaneous hyper-reactivity to environmental factors. Subjects experiencing this condition report exaggerated reactions when their skin is in contact with cosmetics, soaps and sun screens, and they often report worsening after exposure to dry and cold climate. Although no sign of irritation is commonly detected, itching, burning, stinging and a tight sensation are constantly present. Generally substances that are not commonly considered irritants are involved in this abnormal response.Sensitive skin and subjective irritation are widespread but still far from being completely defined and understood. A correlation between sensitive skin and constitutional anomalies and/or other triggering factors such as occupational skin diseases or chronic exposure to irritants has been hypothesized. Recent findings suggest that higher sensitivity can be due to different mechanisms. Hyper-reactors may have a thinner stratum corneum with a reduced corneocyte area causing a higher transcutaneous penetration of water-soluble chemicals. Alterations in vanilloid receptors and changes in neuronal transmission have been described. Monitoring skin parameters such as barrier function, proclivity to irritation, corneocyte size and sensorial transmission can also be useful to identify regional differences in skin sensitivity. Ré suméLa peau sensible est une condition de l'hyperréactivité cutanée subjective à des facteurs environnementaux. Les sujets souffrant de cette condition signalent des réactions exagérées lorsque leur peau est en contact avec des cosmétiques, des savons et des écrans solaires, et ils mentionnent souvent une aggravation après une exposition à un climat sec et froid. Bien qu'aucun signe d'irritation ne soit généralement détecté, les démangeaisons, sensations de brû -lure, de picotement et tiraillement sont constamment présentes. En général, les substances qui ne sont pas habituellement considérées comme irritantes sont impliquées dans cette réponse anormale. La peau sensible et l'irritation subjective sont largement répandues mais encore loin d'être complètement définies et comprises. Une corrélation entre la peau sensible et les anomalies constitutionnelles et / ou d'autres facteurs déclenchants tels que les maladies professionnelles de la peau ou l'exposition chronique à des irritants a été émise comme hypothèse. Des découvertes récentes suggèrent qu'une sensibilité augmentée peut être due à différents mécanismes. Les hyperréactifs peuvent présenter une couche cornée mince avec une zone de cornéocytes réduite entraînant une meilleure pénétra-tion transcutanée de produits chimiques solubles dans l'eau. Des modifications des récepteurs vanilloïdes et des changements dans la transmission neuronale ont été décrits. La surveillance des paramètres de la peau telles que la fonction de barrière, la propension à l'irritation, la taille des cornéocytes et de la transmission sensorielle peut également être utile pour identifier les différences régionales dans la sensibilité cut...

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“…It was also shown that treatment with APHC1 improved the effects on the pain response in both acute and chronic pain models [214]. Therefore, this protein is a very interesting molecule for targeting TRPV1 to reduce irritation in sensitive skin [215].…”

Section: Providing Solutions For Sensitive Skin: Neurocosmetic Ingredientsmentioning

confidence: 98%

Neurocosmetics in Skincare—The Fascinating World of Skin–Brain Connection: A Review to Explore Ingredients, Commercial Products for Skin Aging, and Cosmetic Regulation

et al. 2021

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The “modern” cosmetology industry is focusing on research devoted to discovering novel neurocosmetic functional ingredients that could improve the interactions between the skin and the nervous system. Many cosmetic companies have started to formulate neurocosmetic products that exhibit their activity on the cutaneous nervous system by affecting the skin’s neuromediators through different mechanisms of action. This review aims to clarify the definition of neurocosmetics, and to describe the features of some functional ingredients and products available on the market, with a look at the regulatory aspect. The attention is devoted to neurocosmetic ingredients for combating skin stress, explaining the stress pathways, which are also correlated with skin aging. “Neuro-relaxing” anti-aging ingredients derived from plant extracts and neurocosmetic strategies to combat inflammatory responses related to skin stress are presented. Afterwards, the molecular basis of sensitive skin and the suitable neurocosmetic ingredients to improve this problem are discussed. With the aim of presenting the major application of Botox-like ingredients as the first neurocosmetics on the market, skin aging is also introduced, and its theory is presented. To confirm the efficacy of the cosmetic products on the market, the concept of cosmetic claims is discussed.

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New peptidic active ingredient to reduce discomfort and painful sensations in sensitive skin

Cited by 5 publications

References 0 publications

Sensitive skin

Sensitive skin

Sensitive skin: an overview

Neurocosmetics in Skincare—The Fascinating World of Skin–Brain Connection: A Review to Explore Ingredients, Commercial Products for Skin Aging, and Cosmetic Regulation

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